Stampeders vs Roughriders Prediction, Picks & Odds for Week 21

With the reeling Calgary Stampeders set to enter Mosaic Stadium to close out the year, Trevor Knapp is backing the surging Saskatchewan Roughriders to extend their winning streak into the postseason.

Trevor Knapp - Publishing Editor at Covers.com
Trevor Knapp • Publishing Editor
Oct 25, 2024 • 10:02 ET • 4 min read
Mario Alford Saskatchewan Roughriders CFL
Photo By - Imagn Images

While it remains up in the air how motivated the Saskatchewan Roughriders will be to go all out for this weekend's matchup, the Calgary Stampeders' dismal 2024 campaign has my Stampeders vs. Roughriders predictions siding with the home team in Week 21's regular-season finale. 

Here are my latest CFL picks for Saturday, October 26.

Stampeders vs Roughriders prediction

My best bet
Roughriders -3.5 (-110 at FanDuel)

My analysis

The stakes for the 9-7-1 Saskatchewan Roughriders on Saturday all hinge on the Winnipeg Blue Bombers' same-day matchup against the Montreal Alouettes. With a win in Montreal, the 10-7 Bombers would clinch first place in the West Division, thus rendering the result of the Roughriders matchup against the Calgary Stampeders meaningless. 

However, if the Alouettes sneak out a win (they currently enter as 7.5-point home dogs), a Rider win in front of the Regina faithful would vault Saskatchewan to a first-place finish in the division — something the team hasn't accomplished since 2019.

Regardless of whether the Riders' chances to host a West Final come to fruition, Corey Mace's unit should come out strong out of the gates against a lifeless Calgary team that fell behind 30-9 to Hamilton just a week ago. Saskatchewan should be especially potent on the ground, feasting on a Stampeders run defense that is allowing a league-worst 6.7 yards per attempt. 

Calgary has fallen apart at the seams over the second half of the season, going 1-9 SU and 2-8 ATS over its last 10 contests. Dave Dickenson's roster has been especially plagued by poor quarterback play throughout 2024, and last week's starter Matt Shiltz was forced to leave before halftime after suffering a neck injury. 

With Calgary forced to return to Jake Maier (19-14 TD/INT ratio) and Logan Bonner (0-5 TD/INT) as their options under center, Saskatchewan should coast to their fifth straight win. 

Stampeders vs Roughriders same-game parlay (SGP)

Roughriders -3.5

Over 49.5

Along with my best, I'm backing a high-scoring affair simply based off game script. I expect the Riders to come out firing on all cylinders in order to grab a multiple possession lead and be afforded the chance to rest key starters.

This will result in a pass-happy game script from Calgary in the second half to keep the points coming in shorter order, featuring a littany of possessions from both sides. 

Learn how to bet a same-game parlay with these helpful tips and strategies.

Stampeders vs Roughriders odds

Stampeders vs Roughriders live odds

Stampeders vs Roughriders opening odds

  • Spread: Calgary +3.5 (-110) | Saskatchewan -3.5 (-110)
  • Moneyline: Calgary +160 | Saskatchewan -190
  • Over/Under: Over 49.5 (-110) | Under 49.5 (-110)

Stampeders vs Roughriders spread and Over/Under analysis

  • The Roughriders are 4-0 ATS in their last four games overall.
  • The Stampeders are 0-5 ATS in their last five road games.
  • The Over is 5-2 in the last seven head-to-head meetings.

Stampeders vs Roughriders trend

The Over is 12-3 in Saskatchewan's last 15 home games. Find more CFL betting trends for Stampeders vs. Roughriders.

Stampeders vs Roughriders game info

Location: Mosaic Stadium, Regina, SK
Date: Saturday, 10-26-2024
Kick-off: 7:00 p.m. ET
TV: TSN

Stampeders vs Roughriders key injuries

Stampeders: Ishmael Hyman WR (Out), Erik Brooks WR (Out), Daniel Amoako DB (Out), Matt Shiltz QB (Out), Cole Tucker WR (Out), Darius Williams LB (Out). 
Roughriders: Ryquell Armstead RB (Out), Shawn Bane WR (Out), Peter Dodber OL (Out), Lake Korte-Moore DL (Out), Melique Straker LB (Out).
Find our latest CFL injury reports.

Stampeders vs Roughriders weather

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Trevor Knapp - Covers
Publishing Editor

Trevor joined the Covers content team as a publishing editor in early 2022. Growing up in Vancouver, he studied Broadcast and Online Journalism at the British Columbia Institute of Technology (BCIT), and interned with TSN and Sportsnet Radio while also writing for the Daily Hive.

An avid bettor of the MLB, NFL, and CFL, Trevor advises his fellow sports bettors to leave their hearts at the door and not hesitate to fade their favorite team. It's a strategy he follows regularly as an apathetic Toronto Blue Jays and Indianapolis Colts fan.

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