Saturday's Big Ten showdown between Oregon and USC gives us plenty of opportunities to attack the player prop market, with the pregame total set at 61.5 points.
My Oregon vs. USC prop picks target three of our top edges from this Week 4 matchup.
Check out our latest college football picks and Oregon vs. USC prediction for more betting analysis.
Best Oregon vs USC props
Prop pick #1: Jayden Maiava Over 261.5 passing yards
Quarterback performance from a clean pocket is one of the most predictive metrics for signal-callers, and Jayden Maiava has been elite when given good protection in 2026. He has a sterling 12-to-0 touchdown-to-interception ratio from a clean pocket through four games, completing 77.9% of his pass attempts for 10.3 yards per attempt.
Oregon's defense pressured Portland on just 31.8% of its dropbacks last week in one of the most lopsided matchups of the college football season. The Ducks posted a similarly underwhelming pressure rate against Oklahoma State the week prior.
If USC can give Maiava time in the pocket on Saturday, he should have plenty of opportunities to attack Oregon through the air.
Playable to 56%.
Prop pick #2: Zacharyus Williams Over 19.5 receiving yards
Zacharyus Williams had just one reception against Louisiana and one against Rutgers, but he still managed 71 receiving yards across those two contests. Williams is a deep threat for the Trojans, with four of his 10 targets in 2026 coming 10+ yards downfield. That gives him an opportunity to clear this number with a single catch, just as he did against Louisiana.
Williams has been the primary slot receiver for USC early this season, which means he should avoid the tougher assignments against Ify Obidegwu and Na'eem Offord, who play almost exclusively out wide. Expect Williams to have opportunities to make an impact this weekend.
Playable to 55%.
Prop pick #3: King Miller Over 70.5 rushing yards
King Miller has been the clear lead running back for USC this season, averaging 5.3 yards per carry on 64 attempts through four games. He's carried the ball at least 15 times in every game for USC this fall, giving him a strong volume floor even in difficult matchups against formidable defenses.
Oregon bottled up Boise State's ground game but showed some vulnerability against Oklahoma State, allowing Caleb Hawkins to run for 110 yards on 23 attempts.
The Ducks have one of the best defensive lines in the country, but they lost a pair of linebackers to the NFL Draft this past summer, weakening the second level of their run defense. Miller is a dynamic open-field runner who excels at making defenders miss in space. If his offensive line can consistently get him through the line of scrimmage, he has the potential for a big day.
Playable to 55%.
- Prop picks: 5-2, +6.61 units
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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