Lions vs Colts Predictions, Picks, and Best Bets for NFL Week 12

Ponnaiya's best bet: Colts WR Josh Downs carves up the Lions secondary on Sunday afternoon.

Rohit Ponnaiya - Betting Analyst at Covers.com
Rohit Ponnaiya • Betting Analyst
Nov 24, 2024 • 11:55 ET • 4 min read
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This article contains predictions for an old game!

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Josh Downs Indianapolis Colts NFL
Photo By - Imagn Images. Pictured: Colts receiver Josh Downs looks to separate for a first down.

The Indianapolis Colts' passing game woke up last week, which spells trouble for the Detroit Lions today.

My Lions vs. Colts predictions and NFL picks for this Week 12 clash on November 23 are betting on a big game from wide receiver Josh Downs.

Kickoff is set for 1:00 p.m. ET from Lucas Oil Stadium in Indianapolis, with the game airing on FOX.

Lions vs Colts prediction and best bet

Who will win Lions vs Colts?

For the first time in franchise history, the Lions are the Super Bowl favorites.

They look like a complete team and have reeled off eight wins in a row, while the Colts have been a middle-of-the-pack squad that has gotten inconsistent play at quarterback. I'd be wary of laying 7.5 points on the Lions, but they'll be one of the most teased teams in Week 12.

My best bet
Josh Downs Over 53.5 receiving yards (-115 at BetMGM)

My analysis

Wide receiver Josh Downs leads the Indianapolis Colts with 50 receptions for 567 yards, and the sophomore has racked up 60+ receiving yards in seven of his last eight games. The one game where he went below that number came against the Dolphins in Week 7 when he was questionable with a toe injury and was nowhere near 100%. 

Downs seems to be at full strength now and he's fresh off an 84-yard performance against the Jets stingy secondary in Week 11. Meanwhile, the Detroit Lions surrender 188.7 receiving yards per game to opposing wide receivers — the second-highest number in the league.

Downs has been consistent despite poor play at QB but the Colts passing game is trending in the right direction with Anthony Ricardson returning from being benched to complete 66.7% of his passes for 272 yards last week.

Colts head coach Shane Steichen was dialing up too many deep throws earlier in the season but his play-calling was much better last week with Richardson throwing more short and intermediate throws. Richardson easily led the NFL with an average depth of target of 13.4 yards through his first five starts, but finished with an ADOT of 9.6 last week. That should lead to more throws to Downs, who runs 72% of his snaps out of the slot. 

It's also worth mentioning that Colts WR Michael Pittman Jr. struggles against man coverage and the Lions play man at the league's highest rate. With Pittman's target share shrinking to 13.8% against man coverage, expect even more targets for Downs.

Lions vs Colts same-game parlay

Josh Downs Over 53.5 receiving yards

Colts +7.5

Over 50.5

While the Lions have been terrific, it won't be easy to cover more than a touchdown on the road against the Colts, who are 5-4 straight up and 7-2 against the spread in their last nine games. Detroit also just placed middle linebacker Alex Anzalone on the IR and could get gashed on the ground by Pro Bowl running back Jonathan Taylor

With the Colts running the ball with Taylor and their passing game trending in the right direction, they should be able to move the ball. However, they'll also give up plenty of points to a highly efficient Lions offense that has averaged an incredible 39.1 points per game over their last seven contests.

Learn how to bet a same-game parlay with these helpful tips and strategies.

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Lions vs Colts odds

Lions vs Colts live odds

Lions vs Colts opening odds

  • Spread: Detroit -7.5 | Indianapolis +7.5
  • Moneyline: Detroit -370 | Indianapolis +290
  • Over/Under: Over 51 | Under 51

Odds courtesy of BetMGM

Lions vs Colts spread and Over/Under analysis

  • The look-ahead line had the Lions at -6.5, but the spread reopened at -7.5 despite the Colts beating the Jets on the road last week.
  • The lookahead total was 49 but reopened at 50.5 due to the Lions dropping 52 points last week and the Colts scoring 28.
  • The Lions are 8-0 SU and 7-1 ATS in their last eight games and have gone an incredible 34-13 ATS (72.3%) since the start of the 2022 season. 
  • The Colts have ruled out LT Bernhard Raimann for the second-straight game, while Pro Bowl center Ryan Kelly and RG Will Fries also remain on the IR.
  • 65% of Covers Consensus users are backing Detroit on the spread, while 72% are taking the Over.

Lions vs Colts betting trend to know

Indianapolis is 7-2 ATS in its last nine games and has gone 4-1 ATS at home this year. Find more NFL betting trends for Lions vs. Colts.

Lions vs Colts game info

Location: Lucas Oil Stadium, Indianapolis, IN
Date: Sunday, 11-24, 2024
Kickoff: 1:00 p.m. ET
TV: FOX

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Betting Analyst

With a background playing soccer, rugby, and boxing, combined with a journalism degree, it's little surprise that Rohit gravitated towards the world of sports betting. He specializes in betting on UFC and college basketball, two sports where the eyeball test can tell you a lot more about matchups than any analytics. Rohit has years of experience handicapping NFL and NBA games as well as niche betting markets such as politics and Oscar odds. He's also the resident CFL expert and formerly hosted "The Chez and Ro Show" with former CFL star Davis Sanchez.

You can catch Rohit breaking down every UFC event with Joe Osborne on "P4P Picks" on the Covers YouTube channel and he also has regular appearances on "Before You Bet" with Joe. In addition, he's a regular guest on "By The Book" on the Monumental Sports Network and makes guest appearances on VSIN's "The Handle" and CBS Sports.

Rohit primarily makes his bets at bet365, which offers a wide variety of prop markets, but also has accounts at several others so he can shop around for the best prices. For Rohit, bankroll management is key. He believes you should never bet what you can't afford to lose and maximize those few betting opportunities where books misprice a line.

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