NFL betting in Week 9 begins with a matchup between two playoff caliber squads as the Green Bay Packers face the San Francisco 49ers on Thursday night.
The Packers are 5-2 but have lost two of their last three games and NFL odds have them as 2.5-point favorites against a banged-up 49ers squad that's 4-4 and fresh off a 37-27 loss against Seattle.
We break down the football odds for the Packers vs 49ers on Thursday Night Football on November 5, with kickoff at 8:20 p.m. ET.
Green Bay Packers at San Francisco 49ers Betting Preview
Weather
It's expected to be a warm and clear night at Levi's Stadium in San Francisco with temperatures ranging from 53 to 79 degrees and a very mild breeze of 4 miles per hour. Be sure to monitor the gametime conditions with our NFL weather info.
Key Injuries
Green Bay: Christian Kirksey LB (Out), Allen Lazard WR (Out), Kevin King CB (Out), David Bakhtiari T (Out), Lane Taylor G (Out).
San Francisco: Trent Williams T (Out), Kendrick Bourne WR (Questionable), Brandon Aiyuk WR (Out), George Kittle TE (Out), Tevin Coleman RB (Out), Jimmy Garoppolo QB (Out), Raheem Mostert RB (Out), Deebo Samuel WR (Out), Jeff Wilson RB (Out), Dee Ford DE (Out), Nick Bosa DE (Out), Solomon Thomas DE (Out), Ezekiel Ansah DE (Out), Richard Sherman CB (Out), Ronald Blair III DE (Out), Jalen Hurd WR (Out), Weston Richburg C (Out), Jordan Reed TE (Probable).
Find our latest NFL injury reports.
Against the Spread (ATS) Pick
The Packers only put up 22 points last week against Minnesota, which is surprising as they totaled 400 yards of offense, were 3-for-3 in red-zone situations and only turned the ball over once.
Penalties and poor run defense proved costly for Green Bay in that contest but they're generally better disciplined and will be facing a 49ers team that managed just 52 yards on the ground in their loss last week to Seattle.
The 49ers made the Super Bowl last year thanks to a dominant defense and a terrific running game, but injuries have hit both areas hard this season. Running backs Raheem Mostert and Jeff Wilson Jr. are on the IR and Tevin Coleman will be out of action again on Thursday as well. That leaves Jerick McKinnon and undrafted rookie JaMycal Hasty as the lead backs—and McKinnon has just 16 rushing yards on 13 carries over his last four games.
As for the Niners stop-unit, they've missed Richard Sherman's leadership in the secondary and their defensive front is dealing with a myriad of injuries to their best pass rushers, including Dee Ford and Nick Bosa. San Fran was third in the league in sacks a year ago but rank just 22nd this year.
Look for Aaron Rodgers and the Packers efficient aerial attack to put on a show on Thursday night and cover this spread.
PREDICTION: Green Bay -2.5 (-110)
Over/Under Pick
Rodgers has been terrific this season, throwing for 1,948 yards through seven games with 20 touchdowns and just two interceptions. But he can't help the defense, as the Packers have also surrendered 26.7 points per game.
While that combination might make you think the Over is the play here, consider that Green Bay has actually cashed the Under in three of their last four games, and the one contest that went above the total hit 50 points—just below the total of 51 for Thursday.
The Niners defense might not be as terrific as last year, but it's still holding opponents to 21.6 points per game. Their offense, on the other hand, has been inconsistent and could be without starting quarterback Jimmy Garoppolo and his best target, tight end George Kittle, who left midway through Sunday's game with ankle injuries. Take the Under.
PREDICTION: Under 51 (-110)
Player Prop
We mentioned how well Rodgers has played this season, but the Packers have been using a balanced attack that averages 27.3 rushing attempts per game.
However, the Packers will be without their second and third-string running backs on Thursday, with Jamaal Williams and AJ Dillon both out due to COVID. In addition, top rusher Aaron Jones has been hampered with a calf strain, and even if he suits up, likely won't be at 100 percent.
Expect the Packers to be forced to lean on their passing attack in this game, which should mean big numbers for Rodgers' favorite target Davante Adams.
Adams is averaging 100.4 receiving yards per game this season and has been targeted fewer than 10 times in just one contest, a game against the Detriot Lions where he was sidelined early due to a hamstring injury. Take the Over on his receiving yards.
PREDICTION: Davante Adams - receiving yards Over 79.5 (-118)
Green Bay vs San Francisco Betting Card
- Green Bay -2.5 (-110)
- Under 51 (-110)
- Davante Adams - receiving yards Over 79.5 (-118)
Did you know that if you parlayed this week’s NFL Green Bay vs. San Francisco picks, you could win $57.33 on a $10 bet?
Use our NFL parlay calculator to create your own parlays and see their potential payouts.
Where can I bet on the NFL?
You can bet on NFL odds at every online and casino sportsbooks, including NFL moneylines, spreads, Over/Under totals and a ton of NFL prop odds. Head over to our best-suggested sportsbooks for the top spots to bet on NFL odds in your area.
