Patrick Mahomes Picks, Predictions & Best Bets — Bills vs Chiefs

Patrick Mahomes has some great matchups to take advantage of against the Bills, and our expert NFL predictions expect an interception-free Sunday.

Jeremy Jones - Betting Analyst at Covers
Jeremy Jones • Betting Analyst
Jan 26, 2025 • 15:27 ET • 4 min read
Patrick Mahomes
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Kansas City Chiefs quarterback Patrick Mahomes has owned the Buffalo Bills in his three career playoff matchups with them and will go for history today at Arrowhead Stadium in the AFC Championship Game.

Looking at the Patrick Mahomes odds, oddsmakers also expect a big game from him. However, we found one market that offers substantial value.

Here are my top NFL picks for Mahomes and the Bills vs. Chiefs in the AFC Championship Game on Sunday, January 26.

Patrick Mahomes player prop picks

  • Best bet
    Patrick Mahomes Under 0.5 interceptions 
    (-120 at BetMGM)

  • SGP pick
    Patrick Mahomes Under 0.5 interceptions
    Josh Allen Over 47.5 rushing yards
    Keon Coleman Over 18.5 receiving yards
    Over 48.5 receiving yards
    (+750 at BetMGM)

Click on each pick to jump to the full analysis.

Patrick Mahomes prop pick

My best bet
Patrick Mahomes Under 0.5 interceptions (-120 at BetMGM)

My analysis
Patrick Mahomes is a perfect 3-0 against Josh Allen and the Buffalo Bills in his playoff career. No starting quarterback in the history of the NFL has ever defeated another starting quarterback in the playoffs four times.

However, there are some nice matchups here that favor Mahomes and the Kansas City Chiefs against this Bills defense.

Mahomes completed a career-high 83.6% of his quick passes this season, which led the NFL. In his last three games, he has averaged a 2.47 second time to throw. He did not throw a single interception in any of those three contests.

Meanwhile, the Bills allow the fourth-highest completion percentage and eighth-highest success rate on quick passes this season.

Not only has Mahomes not thrown an interception in the past three games, but he has also not thrown one since that Week 11 regular season matchup with these Bills.

Both interceptions he threw in that contest were on deep passes, with both throws to “open” receivers – meaning they had at least three yards of separation at the time of the pass.

Mahomes is not going to make those mistakes this time around. In his three playoff games with the Bills, he has a 75.2% completion percentage with eight touchdowns to no interceptions.

I expect Mahomes to utilize that quick passing game again and stay out of the turnover column.


More Bills vs Chiefs picks from Covers


Patrick Mahomes same-game parlay

Patrick Mahomes Under 0.5 interceptions

Josh Allen Over 47.5 rushing yards

Keon Coleman Over 18.5 receiving yards

Xavier Worthy Over 48.5 receiving yards


Starting with our best bet with Mahomes, we will add three other player props to our same game parlay.

Josh Allen has always been a great scrambler, but he especially likes to take off on designed pass plays against the Chiefs. Allen has taken off on 10.4% of dropbacks in his career against the Chiefs compared to just 7.0% against all other opponents.

Allen has surpassed this rushing total in each of his three playoff games against KC and in the regular season game earlier this season.

Keon Coleman loves playing against press coverage, and the Chiefs love to play press coverage. Coleman had 351 yards against press coverage this season, which is the seventh most in the NFL. The Chiefs pressed their outside corners on 51.5% of their snaps this season, which was the most in the NFL. 

I really like Coleman to get at least one catch off beating a corner off the press and this number is low enough that it may only take one.

Finally, I like Xavier Worthy to surpass his receiving total as well. Worthy has been much more heavily targeted on short throws and especially ones behind the line of scrimmage in recent weeks.

The Bill's defense allowed the second-most receiving yards on throws behind the line of scrimmage this season.  

Learn how to bet a same-game parlay with these helpful tips and strategies.

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Jeremy Jones - Covers
Betting Analyst

Jeremy Jones was born and raised in Lexington, Kentucky and has been a massive Wildcats fans since the moment he came into the world. He wrote his first sports article at the tender age of 11 after attending a local AHL hockey game, and a few years later was writing professionally for sites such as Sports Rants, BetAmerica, and TwinSpires.

Jeremy holds a Masters in Sports Administration from Eastern Kentucky University and utilizes all seven betting options available in Kentucky to shop for odds and promos and find the greatest EV in every wager he places.

His best piece of sports betting advice is to stick to consistent unit sizes for every wager. He acknowledges there will occasionally be a bet that has a huge EV and you can play multiple units in one bet, but cautions against raising your unit size, because you can quickly lose all your winnings if you hit a minor cold streak.

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