The 2025 pro football schedule has officially been released, with NFL Thanksgiving Day odds among the most anticipated.
This year’s Thanksgiving tripleheader features an NFC North rivalry in Detroit, Patrick Mahomes and the Kansas City Chiefs visiting Dallas, and a prime-time showdown between the Bengals and Ravens in Baltimore.
Here are the latest NFL odds for Thanksgiving Day, along with an early pick for each game.
NFL Thanksgiving Day Odds
| Matchup | Time (ET) | Spread | Total |
|---|---|---|---|
 Packersvs.  Lions |
12:00 p.m. | -2.5 |
48.5 |
 Chiefsvs.  Cowboys |
4:30 p.m. | +4.5 |
47.5 |
 Bengalsvs.  Ravens |
8:15 p.m. | -5.5 |
49.5 |
Early NFL Thanksgiving Day Picks
Packers vs. Lions odds for Thanksgiving Day
|
Noon ET | |
|---|---|---|
| +120 | Moneyline | -142 |
| +2.5 | Spread | -2.5 |
| o48.5 | Total | u48.5 |
My pick: Over 48.5 (-110 at DraftKings)
The Detroit Lions and Green Bay Packers combined for 65 points in their last head-to-head meeting, with each team moving the ball at will.
Detroit averaged a league-high 33.2 points per game last season, and all the key pieces are back for Dan Campbell's squad.
On the other sideline, the Packers added to their young receiving corps by drafting wideout Matthew Golden in the first round.
With both offenses set to fire on all cylinders, expect a high-scoring affair inside Ford Field on Turkey Day.
Covers NFL betting tools
Chiefs vs. Cowboys odds for Thanksgiving Day
|
4:30 p.m. ET | |
|---|---|---|
| -198 | Moneyline | +164 |
| -4.5 | Spread | +4.5 |
| o47.5 | Total | u47.5 |
My pick: Over 47.5 (-110 at FanDuel)
Although the Dallas Cowboys' defense will be more stable under new defensive coordinator Matt Eberflus, it's hard to overlook a unit that was gashed on the ground and sat in the bottom five in yards per play last season.
Patrick Mahomes will torch them on the fast track at Jerry World, boasting a deep arsenal that will again feature a healthy Rashee Rice. With George Pickens joining CeeDee Lamb to bolster the Cowboys’ receiving corps, Dak Prescott should also be able to air it out — even if much of the damage comes in classic garbage time.
The Kansas City Chiefs' defense lost key veterans in the secondary, including corner Charvarius Ward and safety Justin Reid, and while their younger replacements may eventually settle into Steve Spagnuolo's system, it might be even later in the season when they get fully up to speed.
More NFL betting analysis
- Aaron Rodgers’ record vs. every NFL team
- Patrick Mahomes’ record vs. every NFL team
- Russell Wilson’s record vs. every NFL team
- Josh Allen’s record vs. every NFL team
- Lamar Jackson’s record vs. every NFL team
Bengals vs. Ravens odds for Thanksgiving Day
|
8:15 p.m. ET | |
|---|---|---|
| +185 | Moneyline | -225 |
| +5.5 | Spread | -5.5 |
| o49.5 | Total | u49.5 |
My pick: Ravens -5.5 (-110 at DraftKings)
The Cincinnati Bengals have lost their last four games against the Baltimore Ravens and are just 4-6 ATS in their last 10 head-to-head matchups with their AFC North rivals.
With Lamar Jackson and Derrick Henry spearheading a loaded offense, Baltimore's defense should also see a boost following the draft selections of safety Malaki Starks and edge rusher Mike Green.
Back the Ravens to cover at home, where they went 5-3-1 ATS last season.
Not intended for use in MA.
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