NFL Week 10 Odds and Betting Lines: Rams -2.5 Over Dolphins for MNF

The NFL schedule reaches double digits with Week 10 odds on the board and taking action.

With Sunday wrapped, attention turns to the Monday Night Football bout between the Miami Dolphins and Los Angeles Rams. 

Here’s a look at the NFL Week 10 odds and line movement.

NFL Week 10 Odds

These are the NFL odds for Week 10, highlighted by the final NFL International Series game at 9:30 a.m. ET from Munich, Germany.

Matchup	Time (E.T.)	Odds
Bengals vs Ravens	Thursday 8:15 p.m. Prime	Ravens -6 O/U 52.5
Giants vs  Panthers	Sunday 9:30 a.m. NFL Network	Panthers +6.5 O/U 40.5
Broncos vs Chiefs	Sunday 1:00 p.m. CBS	Chiefs -7.5 O/U 42
Bills vs Colts	Sunday 1:00 p.m. CBS	Colts +4 O/U 46.5
Vikings vs Jaguars	Sunday 1:00 p.m. FOX	Jaguars +7 O/U 43.5
Patriots vs Bears	Sunday 1:00 p.m. FOX	Bears -6 O/U 38.5
49ers vs Buccaneers	Sunday 1:00 p.m. FOX	Buccaneers +6.5 O/U 50.5
Falcons vs Saints	Sunday 1:00 p.m. FOX	Saints +3.5 O/U 46.5
Steelers vs Commanders	Sunday 1:00 p.m. CBS	Commanders -3 O/U 45
Titans vs Chargers	Sunday 4:05 p.m. FOX	Chargers -7.5 O/U 39
Eagles vs Cowboys	Sunday 4:25 p.m. CBS	Cowboys +7.5 O/U 43.5
Jets vs Cardinals	Sunday 4:25 p.m. CBS	Cardinals +1.5 O/U 46.5
Lions vs  Texans	Sunday 8:20 p.m. NBC	Texans +3.5 O/U 50
Dolphins vs Rams	Monday 8:15 p.m. ESPN	Rams -2.5 O/U 49

Lines courtesy of BetMGM as of 11-11.

Giants vs. Panthers odds

Opening line

• Panthers +5.5
• Over/Under 41.5
• View full Giants vs. Panthers odds and matchup
• Read our Giants vs. Panthers picks and predictions

Das ist ekelhaft. The NFL puts its “best foot” forward for this international game in Munich, with the Giants opening up between -4.5 and 5.5-point neutral-site chalk despite the Panthers coming off an improbable win over New Orleans in Week 9. New York is now -6.5 with a high of -7 on Sunday morning. This total opened at 41.5 O/U and is down to as low as 40 points.

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Broncos vs. Chiefs odds

Opening line

• Chiefs -9.5
• Over/Under 41.5
• View full Broncos vs. Chiefs odds and matchup
• Read our Broncos vs. Chiefs picks and predictions

Kansas City got a scare on Monday with a tight overtime win over Tampa Bay. That trimmed look-ahead lines of KC -9.5 to -9 at some books on Tuesday morning with it trickling further to -8.5 by Wednesday. It is now as short as -7.5 on Sunday morning. The Chiefs host Denver on a short week with the Broncos coming off a bad beatdown from Baltimore in Week 9. This total opened at 41.5 points and is up to 42 O/U.

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Bills vs. Colts odds

Opening line

• Colts +4.5
• Over/Under 47.5
• View full Bills vs. Colts odds and matchup
• Read our Bills vs. Colts picks and predictions

After the Colts came up short on Sunday night, oddsmakers opened Buffalo as a 4.5-point road favorite with some books as high as Bills -5 before dropping to -4. As of Sunday morning, there are some Colts +3.5 on the board. The total opened at 47.5 points and has dipped to 46.5.

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Vikings vs. Jaguars odds

Opening line

• Jaguars +4.5
• Over/Under 46.5
• View full Vikings vs. Jaguars odds and matchup
• Read our Vikings vs. Jaguars picks and predictions

The Vikings snapped a two-game slide with a win on Sunday night and opened as 4.5-point road favorites at Jacksonville in Week 10. With Jacksonville announcing QB1 Trevor Lawrence would be out, this line jumped to a touchdown later in the week. The Over/Under opened at 46.5 points and is down to 43 O/U.

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Patriots vs. Bears odds

Opening line

• Bears -7
• Over/Under 38.5
• View full Patriots vs. Bears odds and matchup
• Read our Patriots vs. Bears picks and predictions 

Chicago stumbles back to the Windy City following a bad loss at Arizona in Week 9. The Bears opened as 7-point home favorites hosting New England while the Over/Under hit the board between 38.5 and 39.5 points. Chicago rookie QB Caleb Williams injured his ankle but told the media he would be OK, though. Chicago is down to -6 and the total sits at 38.5 points.

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49ers vs. Buccaneers odds

Opening line

• Buccaneers +6.5
• Over/Under 48.5
• View full 49ers vs. Buccaneers odds and matchup
• Read our 49ers vs. Buccaneers picks and predictions

Tampa Bay has a short week to prep for San Francisco, which could be getting key pieces back on offense. Running back Christian McCaffrey and WR Deebo Samuel are trending toward a Week 10 return, and that has the 49ers opening as big as -6.5 on the road in Tampa. This total opened at 48.5 O/U. That spread got as slim as San Francisco -5 before positive injury updates boosted the line all the way back to -6.5. The total is sitting at 50.5 O/U on Sunday morning.

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Falcons vs. Saints odds

Opening line

• Saints +3
• Over/Under 48.5
• View full Falcons vs. Saints odds and matchup
• Read our Falcons vs. Saints picks and predictions

The Saints continue to freefall and now face a Falcons team picking up steam, having won five of their last six games, including the first meeting with NOLA in Week 3. Atlanta opened as short as -3 and climbed to -4 before buyback on NOLA dropped the spread to Atlanta -3.5. This total opened at 48.5 and is down to 46.5. 

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Steelers vs. Commanders odds

Opening line

• Commanders -2.5
• Over/Under 44.5
• View full Steelers vs. Commanders odds and matchup
• Read our Steelers vs. Commanders picks and predictions

The Commanders improved to 7-2 on the season with a win over New York in Week 9 but get their toughest test of 2024 in the surging Steelers. Pittsburgh is coming off the bye and rides a three-game winning streak into this non-conference contest. Washington opened at -2.5 and was up to -3 at some books on Wednesday before buyback on the Steelers knocked it back to the opening number. The Over/Under number opened at 44.5 O/U and has since bumped up to 45.

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Titans vs. Chargers odds

Opening line

• Chargers -7.5
• Over/Under 38.5
• View full Titans vs. Chargers odds and matchup
• Read our Titans vs. Chargers picks and predictions

The Chargers are getting hot, winning three of their last four games. Los Angeles opened as low as a 7.5-point home favorite but some books were dealing Chargers -8.5 just hours after posting odds. There has been action on the Titans, which made this spread Bolts -7.5. This total opened at 38.5 and dropped down to 37.5 O/U before Over money moved it to 39 points. 

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Eagles vs. Cowboys odds

Opening line

• Cowboys +6
• Over/Under 44.5
• View full Eagles vs. Cowboys odds and matchup
• Read our Eagles vs. Cowboys picks and predictions (coming soon)

The Cowboys have major injury concerns on offense, with QB Dak Prescott out of action after a bad Week 9 loss to Atlanta. Philadelphia opened as a 6-point favorite in Dallas with some books up to -7.5 by Wednesday. This total opened at 44.5 and dropped to 42 before some buyback to 43.5, given WRs CeeDee Lamb and A.J. Brown are expected to play.

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Jets vs. Cardinals odds

Opening line

• Cardinals -1
• Over/Under 45
• View full Jets vs. Cardinals odds and matchup
• Read our Jets vs. Cardinals picks and predictions

The Jets have enjoyed a mini-bye after a big home win last Thursday while the Cardinals are riding high following a one-sided win over Chicago at home. Arizona opened as a 2-point favorite, but some books are as short as Cardinals -1 on Sunday night. This spread hovered around pick'em in the middle of the week and has settled at Jets -1.5 heading toward kickoff. This total number opened between 45 and 45.5 points and moved to 46 O/U.

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Lions vs. Texans odds

Opening line

• Texans +3
• Over/Under 48.5
• View full Lions vs. Texans odds and matchup
• Read our Lions vs. Texans picks and predictions

Sunday Night Football in a non-conference contest with the Lions rolling into Houston as red-hot favorites. Books opened Detroit -3 and that quickly ran through key numbers to -4.5 in mere minutes on Sunday night. That spread got as high as Texans +5 before respected money bought back the home underdog and dropped the line to a fielf goal. From there, public play on the Lions has moved this spread back to -3.5. This Over/Under total opened at 48.5 and is up to 49.5 points. The Texans are dinged up on defense but coming off a mini-bye after losing last Thursday and standout WR Nico Collins is a game-time call.

Also see: full Sunday Night Football odds

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Dolphins vs. Rams odds

Opening line

• Rams -3
• Over/Under 49.5
• View full Dolphins vs. Rams odds and matchup
• Read our Dolphins vs. Rams picks and predictions

Monday Night Football gives us another NFC vs. AFC prime-time pairing, with the Rams opening as 2.5-point favorites hosting the Dolphins in the Week 10 finale. Los Angeles has won three in a row while Miami limps to L.A. on a three-game losing skid. Still, enough money has come in on Miami to move the line to Rams -1.5 until reverting to -2.5 by Monday morning. The Over/Under hit the board at 49.5 and jumped to 50.5 before buyback on the Under settled it back at 49.

Also see: full Monday Night Football odds

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More weekly NFL odds content

• Week 1 odds
• Week 2 odds
• Week 3 odds
• Week 4 odds
• Week 5 odds
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• Week 8 odds
• Week 9 odds
• Week 11 odds
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• Week 18 odds

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