NFL Odds Week 16: Lines & Spreads For Every Game

NFL odds Week 16

Matchup	Spread	Moneyline	Over/Under
Broncos vs Chargers	Chargers -2.5	Broncos +120 Chargers -145	41.5
Texans vs Chiefs	Chiefs -3.5	Texans +165 Chiefs  -200	42
Steelers vs Ravens	Ravens -7	Steelers +280 Ravens -360	44.5
Giants vs Falcons	Falcons -8.5	Giants +350 Falcons -450	43
Patriots vs Bills	Bills -14	Patriots +650 Bills -1000	46.5
Lions vs Bears	Bears +6.5	Lions -360 Bears +280	48
Browns vs Bengals	Bengals -9	Browns +350 Bengals -450	47
Titans vs Colts	Colts -3.5	Titans +155 Colts -190	42.5
Rams vs Jets	Jets +3	Rams -190 Jets +140	46.5
Eagles vs Commanders	Commanders +3.5	Eagles -190 Commanders +155	45.5
Cardinals vs Panthers	Panthers +4.5	Cardinals -225 Panthers +185	47
Vikings vs Seahawks	Seahawks +3	Vikings -155 Seahawks +130	42.5
Jaguars vs Raiders	Raiders -1.5	Jaguars +105 Raiders -120	40
49ers vs Dolphins	Dolphins -1	49ers -110 Dolphins -110	44.5
Buccaneers vs Cowboys	Cowboys +4	Buccaneers -210 Cowboys +170	48.5
Saints vs Packers	Packers -14	Saints +650 Packers -1000	42.5

Lines as of 12-21

The NFL Week 16 odds carry a lot of weight.

The postseason push is in full swing, with teams fighting for division titles, home-field advantage, and Wild Card tickets in the final three weeks of the regular season.

That intensity starts on Thursday when the Los Angeles Chargers host the Denver Broncos in a heavy AFC West matchup. 

We have two Saturday showdowns, with the Kansas City Chiefs hosting the Houston Texans and a classic AFC North grudge match between the Pittsburgh Steelers and Baltimore Ravens.

The Philadelphia Eagles and Washington Commanders headline Sunday’s slate in an NFC East encounter as well as an interesting matchup between the Minnesota Vikings and Seattle Seahawks.

Week 16 ends with the New Orleans Saints visiting Lambeau Field and the Green Bay Packers on Monday night.

Here are the opening NFL Week 16 odds and early adjustments.

Broncos vs Chargers odds (Thursday, 8:15 p.m. ET, Amazon Prime)

Opening line

• Chargers -3
• Over/Under 42
• View full Broncos vs. Chargers odds and matchup
• Read our Broncos vs. Chargers picks and predictions

The Chargers tumbled in Week 15 while the Broncos picked up a big home win, which leaves L.A. opening as a 3-point favorite for Thursday Night Football. These rivals are vying for a Wild Card spot in the AFC side of the tournament. This total opened at 42 points. Both numbers have ticked down half a point to Chargers -2.5 and O/U 41.5.

Also see: full Thursday Night Football odds

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Texans vs Chiefs odds (Saturday, 1:00 p.m. ET, NBC)

Opening line

• Chiefs +1.5
• Over/Under 41
• View full Texans vs. Chiefs odds and matchup
• Read our Texans vs. Chiefs picks and predictions

All eyes are on Patrick Mahomes’ ankle in Week 16. He hobbled off the field in the Chiefs win at Cleveland on Sunday and was initially listed as week-to-week with one less day to rest up, as this game takes place on Saturday. Books opened Kansas City as a 1.5-point home underdog — padding the point spread in case Mahomes can’t play — and early action is trying to get out ahead of any updates, moving the number to Texans -2.5. However, Mahomes is saying he's preparing to play unless his ankle is so bad that it puts him and the team in a precarious position. As a result, this spread is back to Chiefs -3 on Wednesday. This total hit the board at 41 points and has ticked up slightly to 41.5.

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Steelers vs Ravens odds (Saturday, 4:30 p.m. ET, FOX)

Opening line

• Ravens -6.5
• Over/Under 46.5
• View full Steelers vs. Ravens odds and matchup
• Read our Steelers vs. Ravens picks and predictions

Baltimore and Pittsburgh have a Saturday showcase in Week 16, with the Ravens opening as 6.5-point home favorites. The status of Pittsburgh WR George Pickens is one to watch as he’s sat out the past two games. This total opened at 46.5 points and has since dropped as low as 44. Cold and wind gusts up to 41 mph are in the extended forecast.

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Giants vs Falcons odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Falcons -9.5
• Over/Under 42.5
• View full Giants vs. Falcons odds and matchup
• Read our Giants vs. Falcons picks and predictions

The Falcons won an ugly game in Las Vegas on Monday and opened between -9.5 and -10 hosting the Giants in Week 16. This total hit the board at 42.5 points and is down to 40.5 O/U at some books. New York could be left with Tim Boyle as the only healthy QB on the depth chart.

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Patriots vs Bills odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

• Bills -12.5
• Over/Under 46.5
• View full Patriots vs. Bills odds and matchup
• Read our Patriots vs. Bills picks and predictions

The Bills are riding high off a huge win at Detroit on Sunday. Bookies opened Buffalo as a 13.5-point home chalk and that has already busted through the key number of two touchdowns, jumping to Bills -14.5. The Over/Under opened at 45.5 and is up to 46.5 O/U. The forecast for Orchard Park looks nasty on Sunday, with wind gusts flirting with 40 mph, snow, and "feels like" temperatures at 4 degrees. This game was initially slated for a 1 p.m. start but has been flexed into a late-afternoon kickoff.

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Lions vs Bears odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Bears +6.5
• Over/Under 46.5
• View full Lions vs. Bears odds and matchup
• Read our Lions vs. Bears picks and predictions

The Bears got bounced by the Vikings on Monday night and now open as 6.5-point home pups to the Lions. Detroit’s defense continued to lose bodies to injury and RB David Montgomery is out for the season with a knee injury. The Over/Under opened at 46.5 and is up to 48 at some books.

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Browns vs Bengals odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Bengals -6.5
• Over/Under 49.5
• View full Browns vs. Bengals odds and matchup
• Read our Browns vs. Bengals picks and predictions

The Bengals opened as 6.5-point home favorites in this Battle of Ohio and jumped to -7 with Cleveland RB Nick Chubb out with a broken leg. Some books are offering Cincy -7.5 on Wednesday morning. The total opened at 49.5 points with two offenses that push the ball deep. However, the O/U is as low as 46.5 now. The extended forecast for Cincinnati calls for sub-freezing temperatures and wind gusts over 21 mph. 

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Titans vs Colts odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Colts -5.5
• Over/Under 43.5
• View full Titans vs. Colts odds and matchup
• Read our Titans vs. Colts picks and predictions

The Colts opened as 5.5-point home favorites and money came in against Indianapolis, dropping the spread to -3.5. Colts WR Alec Pierce left Week 15 with a concussion. Tennessee will likely start QB Mason Rudolph after benching Will Levis this past Sunday. The Over/Under opened at 43.5 O/U and has fallen a point to 42.5.

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Rams vs Jets odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Jets +3
• Over/Under 46.5
• View full Rams vs. Jets odds and matchup
• Read our Rams vs. Jets picks and predictions

The L.A. Rams get a mini-bye after a big win last Thursday but now have to travel to the East Coast for an early kickoff in what looks to be some nasty winter weather. The forecast for East Rutherford calls for wind gusts up to 36 mph cooling temperatures to “feels like” 15 degrees. Los Angeles opened as a 3-point road favorite with the total climbing from 46.5 to 47.5 O/U.

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Eagles vs Commanders odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Commanders +3.5
• Over/Under 46.5
• View full Eagles vs. Commanders odds and matchup
• Read our Eagles vs. Commanders picks and predictions

A big NFC East matchup has the Eagles opened as short as -3.5 on the road at Washington. Philadelphia got a scare with WR A.J. Brown but it appears his ankle is OK. Quarterback Jalen Hurts is playing through a broken finger on his non-throwing hand. This spread is up to Philly -4 at some shops on Sunday night. The total opened at 46.5 points and is now at 45.5 at most books. The early forecast for Hyattsville sees wind gusts flirting with 40 mph and temperatures “feeling like” 21 degrees.

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Cardinals vs Panthers odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Panthers +4.5
• Over/Under 45.5
• View full Cardinals vs. Panthers odds and matchup
• Read our Cardinals vs. Panthers picks and predictions

Carolina opened as big as a 4.5-point home underdog to Arizona in Week 16. The Over/Under hit the board at 45.5 points and climbed to 46.5 O/U on Sunday night. It's ticked up even further to 47.5 at some books on Wednesday. Even Charlotte can’t avoid this cold snap on Sunday, with wind gusts up to 30 mph making it “feel like” 33 degrees on the field.

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Vikings vs Seahawks odds (Sunday, 4:05 p.m. ET, FOX)

Opening line

• Seahawks +3
• Over/Under 43.5
• View full Vikings vs. Seahawks odds and matchup
• Read our Vikings vs. Seahawks picks and predictions

Minnesota looked strong on Monday night, putting a beating on the Bears for an easy win. The Vikings opened as 3-point favorites at Seattle and have jumped to -3.5 with early action on the road side. Seahawks QB Geno Smith injured his knee in Week 15 but is expected to be at practice and playing on Sunday. This total opened at 43.5 points.

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Jaguars vs Raiders odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

• Raiders -1.5
• Over/Under 40.5
• View full Jaguars vs. Raiders odds and matchup
• Read our Jaguars vs. Raiders picks and predictions

The Raiders opened as home favorites of -1.5 to Jacksonville and this line immediately jumped the fence to Jaguars -1.5 after the poor performance from the Silver & Black against Atlanta on Monday night. Depending on the book, you can find either team around -1.5. This total opened at 40.5 and is down to 39.5 points. Las Vegas could have Aidan O’Connell back under center for Week 16.

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49ers vs Dolphins odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

• Dolphins -2.5
• Over/Under 46.5
• View full 49ers vs. Dolphins odds and matchup
• Read our 49ers vs. Dolphins picks and predictions

Mike McDaniel goes head-to-head with his mentor Kyle Shanahan in this non-conference clash. Miami needs a win to stay alive in the AFC playoff hunt while the 49ers do enjoy a mini-bye after last Thursday's loss. The Dolphins opened as 2.5-point home favorites with the total hitting the board at 46.5 points. Miami WR Jaylen Waddle is questionable after a knee injury on Sunday. Dolphins -1 is now available at several books.

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Buccaneers vs Cowboys odds (Sunday, 8:20 p.m. ET, NBC)

Opening line

• Cowboys +4.5
• Over/Under 48.5
• View full Buccaneers vs. Cowboys odds and matchup
• Read our Buccaneers vs. Cowboys picks and predictions

Sunday Night Football sends Tampa Bay to Dallas, with the Cowboys opening as high as +4.5 and drawing early action. Dallas is as short as +3.5 on Sunday night. This total opened at 48.5 points but dropped to 47.5 points with early play on the Under before rebounding as high as 49 by Wednesday.

Also see: full Sunday Night Football odds

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Saints vs Packers odds (Monday, 8:15 p.m. ET, ESPN/ABC)

Opening line

• Packers -12.5
• Over/Under 42.5
• View full Saints vs. Packers odds and matchup
• Read our Saints vs. Packers picks and predictions (coming soon)

Green Bay, coming off a sound victory at Seattle on Sunday, hit the board as a 12.5-point home favorite in Lambeau Field in Week 16 and has been bet up to -13.5 and -14 at some books. New Orleans comes to Wisconsin with a wintery forecast ahead, calling for game-time temperatures to “feel like” 14 degrees. Saints QB Derek Carr is still trying to clear concussion protocols and would also be playing with a fracture in his non-throwing hand in Week 16. This total opened at 42.5 points and Carr’s status will have a huge impact on where that number goes later in the week.

Also see: full Monday Night Football odds

More weekly NFL odds content

• Week 1 odds
• Week 2 odds
• Week 3 odds
• Week 4 odds
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