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MLB picks are bet suggestions based on our computer's assessment of the game. Tons of betting data goes into a computer pick, including pitching matchups, injury reports, analytics, and even recent betting trends.
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Get free expert and computer MLB picks for every game on Sept. 21, 2026.
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Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
4.10 |
-104 
|
o7.5 -110 
|
-1.5 +162 
|
|
4.12 |
-109 
|
u7.5 -105 
|
+1.5 -180 
|
Toronto
- Over is 5-0 in Blue Jays last 5 vs. American League East.
- Over is 5-0 in Blue Jays last 5 during game 1 of a series.
- Over is 4-0 in Blue Jays last 4 after scoring 5 runs or more in their previous game.
- Under is 4-0 in Yesavages last 4 starts following a team loss in their previous game.
Baltimore
- Under is 6-1 in Orioles last 7 home games vs. a team with a losing road record.
- Under is 6-1 in Orioles last 7 home games vs. a team with a losing record.
- Orioles are 6-1 in their last 7 home games vs. a team with a losing road record.
- Orioles are 5-1 in their last 6 home games vs. a team with a losing record.
Top Projection
George Springer o0.5 Total RBIs (+170)
o0.5+180
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
4.49 |
+133
|
o8.0 -119 
|
+1.5 -159
|
|
4.32 |
-150
|
u8.5 -120 
|
-1.5 +140
|
Washington
- Nationals are 7-0 in their last 7 games as a road favorite.
- Under is 6-0 in Nationals last 6 interleague games as an underdog.
- Nationals are 4-0 in their last 4 interleague games as a favorite.
- Under is 4-0 in Nationals last 4 interleague road games vs. a team with a losing record.
Detroit
- Under is 6-0 in Tigers last 6 interleague games as an underdog.
- Tigers are 6-0 in their last 6 interleague games as a favorite.
- Over is 2-0-2 in Tigers last 4 home games.
- Tigers are 4-0 in their last 4 home games.
Top Projection
Andres Chaparro o1.5 Hits+Runs+RBIs (+210)
o1.5+210
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
4.81 |
-115
|
o8.0 -115
|
-1.5 +145
|
|
3.88 |
+105
|
u8.5 -120
|
+1.5 -160
|
Minnesota
- Over is 5-0 in Twins last 5 games as an underdog.
- Over is 6-0 in Twins last 6 after allowing 2 runs or less in their previous game.
- Over is 4-0 in Twins last 4 interleague road games vs. a team with a losing record.
- Over is 7-1 in Twins last 8 interleague games as a favorite.
San Francisco
- Over is 6-0-1 in Giants last 7 games a home underdog.
- Over is 5-0-1 in Giants last 6 home games vs. a team with a losing road record.
- Over is 4-0 in Giants last 4 home games.
- Over is 4-0 in Giants last 4 games as a favorite.
Top Projection
Kody Clemens o0.5 Total RBIs (+171)
o0.5+171
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
3.35 |
+115 
|
o6.5 -150
|
-1.5 +210
|
|
4.44 |
-135
|
u9.5 -339
|
+2.5 -450
|
Tampa Bay
- Over is 7-0-1 in Rasmussens last 8 starts with 5 days of rest.
- Under is 5-0 in Rays last 5 vs. American League East.
- Over is 4-0-1 in Rasmussens last 5 starts vs. American League East.
- Under is 6-0 in Rays last 6 during game 1 of a series.
NY Yankees
- Over is 4-0 in Yankees last 4 games as a favorite.
- Over is 4-0 in Yankees last 4 during game 1 of a series.
- Yankees are 4-0 in their last 4 during game 1 of a series.
- Yankees are 4-0 in their last 4 when their opponent allows 2 runs or less in their previous game.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
|
4.39 |
-- |
-- |
-- |
|
|
4.50 |
-- |
-- |
-- |
Toronto
- Over is 5-0 in Blue Jays last 5 vs. American League East.
- Over is 8-1 in Blue Jays last 9 overall.
- Over is 6-1 in Blue Jays last 7 games as a favorite.
- Over is 6-1 in Blue Jays last 7 vs. a team with a losing record.
Baltimore
- Under is 6-1 in Orioles last 7 home games vs. a team with a losing road record.
- Under is 6-1 in Orioles last 7 home games vs. a team with a losing record.
- Orioles are 6-1 in their last 7 home games vs. a team with a losing road record.
- Orioles are 5-1 in their last 6 home games vs. a team with a losing record.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
|
3.89 |
-- |
-- |
-- |
|
|
4.24 |
-- |
-- |
-- |
Washington
- Nationals are 7-0 in their last 7 games as a road favorite.
- Under is 6-0 in Nationals last 6 interleague games as an underdog.
- Nationals are 4-0 in their last 4 interleague games as a favorite.
- Under is 4-0 in Nationals last 4 interleague road games vs. a team with a losing record.
Detroit
- Under is 6-0 in Tigers last 6 interleague games as an underdog.
- Tigers are 6-0 in their last 6 interleague games as a favorite.
- Over is 2-0-2 in Tigers last 4 home games.
- Tigers are 4-0 in their last 4 home games.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
3.70 |
-- |
-- |
-- |
|
4.37 |
-- |
-- |
-- |
Milwaukee
- Over is 7-1-1 in Brewers last 9 games as a road underdog.
- Over is 6-1-1 in Brewers last 8 games as an underdog.
- Brewers are 5-1 in their last 6 road games.
- Brewers are 5-1 in their last 6 vs. a team with a winning record.
Philadelphia
- Over is 3-0-1 in Phillies last 4 vs. National League Central.
- Under is 5-1 in Phillies last 6 games as a home underdog.
- Over is 5-1 in Phillies last 6 games as an underdog.
- Over is 7-2 in Phillies last 9 overall.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
4.05 |
-- |
-- |
-- |
|
4.28 |
-- |
-- |
-- |
St. Louis
- Cardinals are 6-0 in Pallantes last 6 starts during game 1 of a series.
- Over is 5-0 in Cardinals last 5 games as a road favorite.
- Over is 4-0 in Pallantes last 4 starts as a road favorite.
- Over is 4-0 in Pallantes last 4 starts as a favorite.
Pittsburgh
- Pirates are 4-0 in their last 4 home games.
- Pirates are 4-0 in their last 4 overall.
- Pirates are 4-0 in their last 4 games as a home favorite.
- Pirates are 4-0 in their last 4 games as a favorite.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
3.71 |
-- |
-- |
-- |
|
3.70 |
-- |
-- |
-- |
Cleveland
- Guardians are 5-0 in their last 5 overall.
- Over is 6-0 in Guardians last 6 games as a road underdog.
- Over is 5-0 in Guardians last 5 vs. American League East.
- Guardians are 5-0 in their last 5 games on grass.
Boston
- Under is 7-0 in Red Sox last 7 when their opponent scores 2 runs or less in their previous game.
- Under is 4-0 in Red Sox last 4 games as a favorite.
- Under is 4-0 in Red Sox last 4 games as an underdog.
- Under is 4-0 in Red Sox last 4 during game 1 of a series.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
|
3.32 |
-- |
-- |
-- |
|
|
3.79 |
-- |
-- |
-- |
Tampa Bay
- Under is 5-0 in Rays last 5 vs. American League East.
- Under is 5-1 in Rays last 6 overall.
- Under is 5-1 in Rays last 6 games as a favorite.
- Rays are 5-1 in their last 6 games as a road underdog.
NY Yankees
- Over is 4-0 in Yankees last 4 games as a favorite.
- Yankees are 7-1 in their last 8 home games.
- Yankees are 7-1 in their last 8 games as a home favorite.
- Over is 6-1-1 in Yankees last 8 games as an underdog.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
4.85 |
-- |
-- |
-- |
|
5.30 |
-- |
-- |
-- |
Cincinnati
- Reds are 4-0 in Abbotts last 4 starts as a favorite.
- Over is 8-2 in Reds last 10 road games.
- Over is 5-1 in Abbotts last 6 starts during game 1 of a series.
- Over is 8-2 in Reds last 10 games as a road underdog.
Atlanta
- Over is 5-0 in Braves last 5 games vs. a starter with a WHIP greater than 1.30.
- Over is 3-0-1 in Braves last 4 games as a favorite.
- Under is 4-0 in Braves last 4 home games following a road trip of 7 or more days.
- Over is 7-1-1 in Braves last 9 overall.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
4.73 |
-- |
-- |
-- |
|
4.17 |
-- |
-- |
-- |
Chi. White Sox
- Over is 5-0 in White Sox last 5 after allowing 2 runs or less in their previous game.
- Under is 4-0 in White Sox last 4 games as a road favorite.
- Over is 5-1 in White Sox last 6 road games.
- Over is 5-1 in White Sox last 6 games following a win.
Kansas City
- Under is 4-0-1 in Royals last 5 home games.
- Under is 8-0-1 in Royals last 9 vs. a team with a winning record.
- Under is 3-0-1 in Royals last 4 home games vs. a team with a losing road record.
- Under is 3-0-1 in Royals last 4 home games vs. a team with a winning record.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
3.53 |
-- |
-- |
-- |
|
4.02 |
-- |
-- |
-- |
Miami
- Over is 6-0-1 in Marlins last 7 games as a favorite.
- Over is 3-0-1 in Marlins last 4 games as a road favorite.
- Over is 4-0 in Marlins last 4 during game 1 of a series.
- Over is 5-1 in Marlins last 6 when their opponent allows 2 runs or less in their previous game.
Chi. Cubs
- Over is 3-0-1 in Cubs last 4 home games.
- Over is 3-0-1 in Cubs last 4 games as a home favorite.
- Over is 3-0-1 in Cubs last 4 home games vs. a team with a losing record.
- Over is 3-0-1 in Cubs last 4 games following a win.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
4.48 |
-- |
-- |
-- |
|
4.64 |
-- |
-- |
-- |
NY Mets
- Over is 5-0 in Manaeas last 5 starts as a road underdog.
- Mets are 4-0 in their last 4 games as a road favorite.
- Over is 4-0 in Manaeas last 4 starts with 6 days of rest.
- Over is 4-0 in Manaeas last 4 starts when their opponent scores 2 runs or less in their previous game.
Texas
- Over is 6-0-1 in Rangers last 7 home games vs. a team with a losing record.
- Under is 6-0 in Rangers last 6 interleague home games vs. a left-handed starter.
- Under is 4-0 in Rangers last 4 interleague games vs. a team with a losing record.
- Over is 3-0-1 in Rangers last 4 vs. a team with a losing record.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
6.30 |
-- |
-- |
-- |
|
5.13 |
-- |
-- |
-- |
Arizona
- Under is 5-0-1 in Diamondbacks last 6 road games.
- Under is 3-0-1 in Diamondbacks last 4 games as a road underdog.
- Diamondbacks are 4-0 in their last 4 games as an underdog.
- Over is 3-0-1 in Diamondbacks last 4 during game 1 of a series.
Colorado
- Over is 5-0 in Rockies last 5 vs. a team with a winning record.
- Over is 4-0 in Rockies last 4 vs. National League West.
- Over is 4-0 in Rockies last 4 home games vs. a team with a winning record.
- Under is 4-0 in Rockies last 4 after allowing 2 runs or less in their previous game.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
4.15 |
-- |
-- |
-- |
|
4.60 |
-- |
-- |
-- |
Houston
- Under is 4-0-2 in Astros last 6 vs. a team with a losing record.
- Under is 3-0-2 in Astros last 5 road games vs. a team with a losing record.
- Under is 8-1 in Astros last 9 games as a favorite.
- Under is 6-1 in Astros last 7 when their opponent scores 2 runs or less in their previous game.
Seattle
- Under is 4-1 in Mariners last 5 overall.
- Over is 8-2 in Mariners last 10 after scoring 2 runs or less in their previous game.
- Under is 4-1 in Mariners last 5 games as a favorite.
- Under is 4-1 in Mariners last 5 on grass.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
5.59 |
-- |
-- |
-- |
|
5.23 |
-- |
-- |
-- |
LA Angels
- Over is 5-0 in Angels last 5 games following a loss.
- Over is 3-0-1 in Angels last 4 after allowing 5 runs or more in their previous game.
- Angels are 4-1 in their last 5 games as a favorite.
- Under is 19-7-1 in Angels last 27 road games.
Athletics
- Over is 10-1 in last 11 vs. American League West.
- Over is 4-1 in last 5 games as a favorite.
- Over is 4-1 in last 5 games as a home favorite.
- Over is 4-1-1 in last 6 on grass.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
|
4.62 |
-- |
-- |
-- |
|
|
3.60 |
-- |
-- |
-- |
Minnesota
- Over is 5-0 in Twins last 5 games as an underdog.
- Over is 4-0 in Twins last 4 interleague road games vs. a team with a losing record.
- Over is 7-1 in Twins last 8 interleague games as a favorite.
- Over is 6-1-1 in Twins last 8 overall.
San Francisco
- Over is 6-0-1 in Giants last 7 games a home underdog.
- Over is 5-0-1 in Giants last 6 home games vs. a team with a losing road record.
- Over is 4-0 in Giants last 4 home games.
- Over is 4-0 in Giants last 4 games as a favorite.
Predicted Score
Team |
Predicted Score |
ML |
Total |
Run Line |
|---|---|---|---|---|
|
4.81 |
-- |
-- |
-- |
|
5.07 |
-- |
-- |
-- |
San Diego
- Over is 8-0 in Padres last 8 road games.
- Over is 7-0 in Padres last 7 vs. National League West.
- Over is 8-0 in Padres last 8 games as a road favorite.
- Padres are 6-0 in their last 6 during game 1 of a series.
LA Dodgers
- Dodgers are 5-0 in their last 5 during game 1 of a series.
- Over is 2-0-2 in Dodgers last 4 overall.
- Dodgers are 6-0 in their last 6 when their opponent scores 5 runs or more in their previous game.
- Over is 2-0-2 in Dodgers last 4 games as a favorite.
TOR
@
BAL
Mon, Sep 21 • 6:35 PM ET
Total
o7.5 (-110)
Jason Wilson
Publishing Editor
Trey Yesavage is making his first start in over a month, and Shane Baz was removed from his most recent outing after taking a comebacker off his elbow. Neither pitcher will be at 100%, and even if the Blue Jays are missing Vladimir Guerrero Jr., it's not like he's really steered the offense anyway. This could turn into a bullpen game pretty early, so I'll take the Over as long as it stays a reasonable price for 7.5.
Total Hits
Nathan Lukes u0.5 Total Hits (+202)
Projection 0.9
EV Model Rating
Star rating: 3 out of 5
Nathan Lukes has been pulled from the game early 18% of the time when starting against a right-handed starter this year.. The wind projects to be blowing in from CF at 8.9-mph in this match-up, the strongest of the day for hurlers.. Nathan Lukes has a 97th percentile opposite-field rate on his flyballs (37.8%) and has the misfortune of hitting them towards the league's 4th-deepest LF fences in today's matchup.. Among every team today, the 2nd-worst infield defense belongs to the Baltimore Orioles.. Nathan Lukes will be at a disadvantage playing as a visiting player today.
WAS
@
DET
Mon, Sep 21 • 6:40 PM ET
Moneyline
WAS (+131)
Josh Inglis
Betting Analyst
There is a lot of variance in this game, and I never like paying juice when the range of outcomes is massive. The fair probability for the Nats is 51%. Both teams are sending starters to the mound who are coming off lengthy injuries. Washington's DJ Herz is coming back from Tommy John but is up to 65 pitches in his last start and has allowed one or fewer runs in all but one of his 11 games before the promotion. I don't see that as a disadvantage vs. the Detroit starter River Ryan, who is up to just 2.2 IP and pitched to a 4.46 ERA at Triple-A after returning from a hamstring injury. This is a lot closer to a coin toss, especially with the Tigers scoring just one run in four of their last five games.
Total Home Runs
Daylen Lile o0.5 Total Home Runs (+500)
Quinn Allen
Betting Analyst
Play up to 16%. Daylen Lile's power has started to emerge, with two homers over his last five games and a .389 ISO. He's also elevating half of his contact while producing a 12.5% barrel rate. River Ryan handled power well in the minors, but Lile's recent profile makes 16% appealing.
MIN
@
SF
Mon, Sep 21 • 9:45 PM ET
Moneyline
MIN (-114)
Jon Metler
Betting Analyst
Give me the Minnesota Twins on the moneyline at 53%, as I make them closer to a 57% favorite against the San Francisco Giants. Zebby Matthews gets the ball for the Twins, coming off a strong outing against the New York Yankees in which he tossed six scoreless innings and struck out eight batters. Matthews is a fly-ball pitcher who aggressively attacks the strike zone and challenges hitters, which has contributed to a high 16.1% HR/FB rate this season. However, pitching at the pitcher-friendly Oracle Park, with its heavy coastal air, large outfield dimensions and nighttime conditions, makes backing Matthews and the Twins much more appealing.
Total
o8.0 (-115)
Jason Wilson
Publishing Editor
The Twins' bullpen is cooked, hence why they turned to Bailey Ober (Monday's initially scheduled starter) for the final three innings on Sunday night. The pitching staff is in flux as a result, and even at a pitcher-friendly park like Oracle, I'll happily take the Over with that shuffling of the deck. Giants starter Blade Tidwell has allowed 19 earned runs in his last nine home innings, so those confines haven't exactly served him well, either.
TB
@
NYY
Tue, Sep 22 • 1:05 PM ET
Total RBIs
Austin Wells o0.5 Total RBIs (+305)
Projection 0.41
EV Model Rating
Star rating: 4 out of 5
Yankee Stadium ranks as the #7 ballpark in the majors for left-handed home runs, per the leading projection system (THE BAT).. Yankee Stadium has the 7th-lowest average fence height among all parks.. Hitting from the opposite that Drew Rasmussen throws from, Austin Wells will have an edge in today's matchup.. Extreme flyball batters like Austin Wells generally hit better against extreme groundball pitchers like Drew Rasmussen.. The Tampa Bay Rays infield defense grades out as the 2nd-weakest among every team on the slate today.
Total RBIs
Cody Bellinger o0.5 Total RBIs (+206)
Projection 0.55
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Cody Bellinger in the 89th percentile when it comes to his overall offensive talent.. Cody Bellinger is projected to hit 4th in the lineup in today's game.. Yankee Stadium ranks as the #7 ballpark in the majors for left-handed home runs, per the leading projection system (THE BAT).. Yankee Stadium has the 7th-lowest average fence height among all parks.. Hitting from the opposite that Drew Rasmussen throws from, Cody Bellinger will have an edge in today's game.
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How To Use MLB Computer Picks
You can use the tables above to help with your bets during the MLB season. The first section includes free, computer-generated picks for daily Major League Baseball games. Baseball bettors can choose to follow the computer, fade the computer, or simply use our computer picks as one element of their betting strategy.
This page also tees up access to deeper betting trends. For example, if a club's run line is favored, you can check their ATS trends, potentially opening up some quality underdog bets.
If you're ready to get started with MLB betting, visit our dedicated page highlighting the best MLB betting sites.
Moneyline
This is the most common and easiest wager for a bettor to make when it comes to MLB picks. Basically, to win an MLB moneyline pick, you just have to choose which team will win the game.
It's simple: if you bet the White Sox moneyline over the Red Sox and Chicago wins, you win your bet.
Run line
The run line is another name for a point spread that you may be more familiar with in NBA and NFL betting. A point spread varies in the NFL and NBA from as little as 0.5 points up to double-digit spreads. A baseball run line is almost always a 1.5-point spread.
The favorite will be -1.5 while the underdog will be +1.5. At the end of the game, if you take away 1.5 runs from the favorite or add 1.5 runs to the underdog and they end up winning the game, you win your MLB pick against the spread.
Totals (Over/Under)
Another common wager is to bet on the total in baseball, which is a bet on the total runs scored in the baseball game. You are simply choosing whether the final score will be Over or Under that total. Betting the Over/Under on a matchup is a great way to get started in MLB score predictions.
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NRFI/YRFI MLB Picks
A new and emerging MLB betting market is the NRFI/YRFI bet. These are quick-hitters in which you make a wager on the O/U total of the first inning, typically set at 0.5 runs. Thus, the bet is coined as No Run First Inning or Yes Run First Inning. No need to wait a couple of hours to cash a bet when it could be done in 20 minutes or less.
First Five Innings MLB Picks
The above options, moneyline, run line, and Over/Under, can also be placed on the first five innings of a game rather than the full game. Many experienced bettors will use this approach because, typically, this will take bullpens out of the equation and make your job researching the game easier. After all, you can just focus on the starting pitchers.
MLB Picks And Parlays
If you want to combine multiple games into one mega wager, you may consider making a parlay bet. A parlay is when you pick two or more MLB games on one single betting ticket, which will increase the payout of your bet.
But it also comes with more risk, as each of those MLB picks must hit for your ticket to pay out. Our parlay calculator is a great tool to find out what your potential payout would be.
If you're looking for more MLB picks content, check out our consensus picks and prop bets pages to get your fix. While you're at it, head over to our MLB promos page to get the best bang for your buck.
MLB Player Props
Player props are a great way to hone in on an individual matchup for a game. These types of wagers will be individualized for a player: Will Shohei Ohtani hit a home run? Will Gerrit Cole get seven strikeouts? Will Paul Skenes allow two earned runs?
You simply choose whether this outcome will happen or not. Keeping up to date on daily pitching matchups and batters on a hot streak can give you a huge boost when placing player prop bets.
MLB Futures Picks
Lastly, prior to the season and even throughout the season, you can place futures bets on all the long-term awards and outcomes. You can lock in an MLB pick on who will win their division, which squad will win the World Series, or even who will win the Rookie of the Year, MVP, or Cy Young.
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