The adverse effects of AASs fall into 4 primary categories: hepatic, reproductive, cardiovascular, and psychiatric effects.
Today I will cover Reproductive Adverse Effects
Adverse Effects on the Male Reproductive System
The effects of the anabolic-androgenic
steroids on the male reproductive system are oligospermia (small number
of sperm) and azoospermia (lack of sperm in the semen), decreased
testicular size, abnormal appearance of testicular biopsy material, and
reductions in testosterone and gonadotropic hormones. These effects have
been shown in training studies,studies of normal volunteers,therapeutic trials,and studies of athletes who were using anabolic-androgenic steroids.In view of the changes shown in the pituitary-gonadal axis, the
dysfunction accounting for these abnormalities is believed to be
steroid-induced suppression of gonadotrophin production.
The changes in these hormones are ordinarily reversible after cessation
of drug treatment, but the long-term effects of altering the
hypothalamic-pituitary-gonadal axis remain unknown. However, there is a
report of residual abnormalities in testicular morphology of healthy men
6 months after discontinuing steroid use. It has been reported that the metabolism of androgens to estrogenic compounds may lead to gynecomastia ( male boobs) in males.
Adverse Effects on the Female Reproductive System
The effects of androgenic steroids on the
female reproductive system include reduction in circulating levels of
luteinizing hormone, follicle-stimulating hormone, estrogens, and
progesterone; inhibition of folliculogenesis and ovulation; and
menstrual cycle changes including prolongation of the follicular phase,
shortening of the luteal phase, and amenorrhea.(no menstruation)
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The adverse effects of AASs fall into 4 primary categories: hepatic, reproductive, cardiovascular, and psychiatric effects.
Today I will cover Reproductive Adverse Effects
Adverse Effects on the Male Reproductive System
The effects of the anabolic-androgenic
steroids on the male reproductive system are oligospermia (small number
of sperm) and azoospermia (lack of sperm in the semen), decreased
testicular size, abnormal appearance of testicular biopsy material, and
reductions in testosterone and gonadotropic hormones. These effects have
been shown in training studies,studies of normal volunteers,therapeutic trials,and studies of athletes who were using anabolic-androgenic steroids.In view of the changes shown in the pituitary-gonadal axis, the
dysfunction accounting for these abnormalities is believed to be
steroid-induced suppression of gonadotrophin production.
The changes in these hormones are ordinarily reversible after cessation
of drug treatment, but the long-term effects of altering the
hypothalamic-pituitary-gonadal axis remain unknown. However, there is a
report of residual abnormalities in testicular morphology of healthy men
6 months after discontinuing steroid use. It has been reported that the metabolism of androgens to estrogenic compounds may lead to gynecomastia ( male boobs) in males.
Adverse Effects on the Female Reproductive System
The effects of androgenic steroids on the
female reproductive system include reduction in circulating levels of
luteinizing hormone, follicle-stimulating hormone, estrogens, and
progesterone; inhibition of folliculogenesis and ovulation; and
menstrual cycle changes including prolongation of the follicular phase,
shortening of the luteal phase, and amenorrhea.(no menstruation)
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