49ers have to deal with their Pacific time body clocks playing in an early game on Eastern time. Never easy. And coming in a day early or whatever does nothing in that short a time. The Noon EST kickoff will f"eel like" 9am PST.
But with today's modern medicines and various 5 hr energies, Starbuck's coffee with jacked up caffeine and those strange smelling salts I have always wondered about, it should not be a factor.