March Madness Big Bets: Multiple Six-Figure Wagers on Duke to Win Tournament

Bettors backing No. 1 seed, ACC champion Blue Devils to cut down the nets in NCAA men's basketball tournament.

Lou Monaco - Contributor to Covers.com.
Lou Monaco • Contributor
Mar 20, 2025 • 10:35 ET • 4 min read
Photo By - Imagn Images.

The first round of the NCAA men's college basketball tournament begins Thursday and the Duke Blue Devils are drawing big bets to win it all.

Hours prior to the kick off of the Round of 64, BetMGM shared that a bettor placed half a million dollars on Duke to claim the national title.

At +350 March Madness odds, the bettor would win $1.75 million.

One Nevada sports bettor placed a $100,000 wager at Caesars Sportsbook on Duke at +360 to cut down the nets and win their sixth national title all-time.

If successful, the bet would pay out $460,000. 

Duke begins play Friday evening

The top-seeded and ACC champion Blue Devils (31-3) will face 16th-seeded and MAAC champion Mount St. Mary's (23-12) in the first round of the East Regional at 2:50 p.m. ET Friday at the Lenovo Center in Raleigh, North Carolina.

The winner will advance to Sunday's second round to face Friday's winner between ninth-seeded Baylor (19-14) and eighth-seeded Mississippi State (21-12) at 12:15 p.m. ET in Raleigh.

"The Mount" already has one win in the tournament, having defeated 16th-seeded American University, 83-72, in the First Four at UD Arena in Dayton, Ohio Wednesday night to advance.

Duke has won 11 straight games since a 77-71 road loss to Clemson on Feb. 8 and is either the favorite or co-favorite to win it all.

However, the big question is whether freshman forward phenom and certain NBA first-rounder Cooper Flagg will be able to play after hurting his ankle a week ago today in the ACC Tournament, an injury which had kept him out of the semifinals and final.

In 32 games started this season, Flagg has averaged 18.9 points, 7.5 rebounds, and 4.1 assists per game.

Longshot bet placed for less money, bigger payout 

Another Nevada bettor at Caesars Sportsbook placed a $8,000 bet on Gonzaga (+6,000) to win it all.

Should the bettor's dream come true, it would cash out for $480,000!

Let the Madness begin!

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Lou Monaco - Contributor to Covers.com
Contributor

Lou Monaco had served as a Stateside Journalist/Betting Analyst for for GDC Media, writing for 30+ sites that covered the sports and casino betting industries with a focus on the East Coast of the US.
 
Currently, he is the night desk manager/boy’s golf coordinator/writer for NJ Advance Media high school sports department in Iselin (NJ) and is a freelance writer for Covers and Rant Sports. Lou has over 30+ years of sports experience with previous stints at ESPN SportsTicker and other major gambling websites.

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