The wait is over, and the 2025 MLB season is officially here.
Opening Day features 28 of 30 teams, and after all kinds of offseason roster moves, it’s finally time for meaningful baseball.
Here are my moneyline MLB picks for all 14 Opening Day games.
Opening Day moneyline picks
| Matchup | Pick |
|---|---|
 Milwaukee Brewers vs  New York Yankees |
(-150) |
 Baltimore Orioles vs  Toronto Blue Jays |
(+103) |
 Philadelphia Phillies vs  Washington Nationals |
(-165) |
 Boston Red Sox vs  Texas Rangers |
(-114) |
 Pittsburgh Pirates vs  Miami Marlins |
(+137) |
 San Francisco Giants vs  Cincinnati Reds |
(-107) |
 Los Angeles Angels vs  Chicago White Sox |
(-143) |
 Cleveland Guardians vs  Kansas City Royals |
(+111) |
 New York Mets vs  Houston Astros |
(+114) |
 Atlanta Braves vs  San Diego Padres |
(-124) |
 Minnesota Twins vs  St. Louis Cardinals |
(-107) |
 Detroit Tigers vs  Los Angeles Dodgers |
(+154) |
 Chicago Cubs vs  Arizona Diamondbacks |
(+119) |
 A's vs  Seattle Mariners |
(-163) |
Lines courtesy of Pinnacle as of 3-26.
Expert Opening Day moneyline picks
Brewers vs. Yankees: Yankees (-150)
The Brewers hit Yankee Stadium with a middling offense, and starter Freddy Peralta was hit hard this spring. New York packs more punch at the dish, and lefty Carlos Rodon has the pitch mix to keep the Brew Crew off balance.
Orioles vs. Blue Jays: Blue Jays (+103)
Toronto was the toast of the Grapefruit League this spring, and Opening Day starter Jose Berrios scattered five earned runs across his 20 2/3 spring innings. Baltimore will miss superstar Gunnar Henderson early, too.
Phillies vs. Nationals: Phillies (-165)
Philadelphia is a World Series contender, and while Washington is moving in the right direction, this is still a sizable mismatch. The Phillies' star power is too much for the Nats on Thursday.
Red Sox vs. Rangers: Red Sox (-114)
Texas veteran Nathan Eovaldi faces a deep and improved Boston lineup, and I’m anticipating Red Sox starter Garrett Crochet picking up where he left off in 2024. Texas ran out a below average offense against southpaws last year, after all.
Pirates vs. Marlins: Marlins (+137)
Sure, the Pirates are sending Cy Young betting favorite Paul Skenes to the hill, but he isn’t going to take care of all 27 outs. Marlins ace Sandy Alcantara showed off this spring and should keep this low-scoring game interesting.
Giants vs. Reds: Reds (-107)
The Reds have the better offense, and as good as Giants ace Logan Webb has been, his ERA has climbed in consecutive seasons. Cincy starter Hunter Greene is a strikeout artist on the ascent, and I’m expecting him to hold the San Fran lineup in check Thursday.
Angels vs. White Sox: Angels (-143)
Chicago didn’t make impact additions during the offseason after finishing with the lowest wRC+ against lefties, and Los Angeles southpaw Yusei Kikuchi was sharp for the Houston Astros down the stretch last season and followed it up with a nice spring. The Angels aren’t world beaters, but they’re not White Sox-level bad, either.
Guardians vs. Royals: Guardians (+111)
Cleveland was sneaky-good against lefties last season with the eighth-highest wRC+ and eighth-lowest strikeout percentage, and Kansas City lefty Cole Ragans recorded a 6.23 ERA and 1.62 WHIP against the Guardians across two starts.
Mets vs. Astros: Mets (+114)
A pair of new-look clubs hit Daikin Park on Opening Day, and I think the wrong one is the betting favorite. The Mets have a power-packed heart of the order, and the Astros watched franchise cornerstones Kyle Tucker and Alex Bregman pack their bags during the offseason. The Houston lineup is thin.
Braves vs. Padres: Braves (-124)
The Braves and Padres are both postseason hopefuls and feature star-studded rosters. I give Atlanta the edge with lefty Chris Sale coming off a dominant 18-win season and a sharp spring.
Twins vs. Cardinals: Twins (-107)
It was a relatively quiet offseason for both the Twins and Cardinals, and both clubs missed the postseason in 2024. Minnesota has the better lineup, and St. Louis starter Sonny Gray didn’t have it this spring (12.56 ERA with eight home runs allowed), so I’m siding with the visitors at Busch Stadium in the opener.
Tigers vs. Dodgers: Tigers (+154)
Let’s take the long odds with Detroit ace Tarik Skubal. The reigning AL Cy Young winner went 18-4 last year and looked as sharp as ever this spring. Dodgers lefty Blake Snell only pitched 4 2/3 innings this spring and has been a notoriously slow starter during his career.
Cubs vs. Diamondbacks: Cubs (+119)
Chicago and lefty Justin Steele have a chance to hit the restart button after a tough Tokyo Series to open the year. Arizona had a league-high .334 BABIP against southpaws last season, and I’m expecting the Cubs bats waking up after plating just four runs across their first two games.
A's vs. Mariners: Mariners (-163)
The Mariners averaged 6.6 runs per spring game after plating just 4.2 per last year, and I’m expecting the bats to keep the runs coming against Athletics starter Luis Severino. Seattle counters with Logan Gilbert, and he sports a solid 3.38 ERA and 3.53 xFIP over the past three years. He is followed by a bullpen that respectively ranked ninth and eighth in the metrics in 2024.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
