Twins vs Yankees Predictions, Picks, Odds: Pitcher's Duel Anticipated in Sunday Finale

Pablo Lopez is the deserving staff ace on the Twins, and he matches up with fellow No. 1 Gerrit Cole in the Bronx on Sunday afternoon. Runs could be at a premium, as our MLB betting picks explain.

Kenny Ducey - Betting Analyst at Covers
Kenny Ducey • Betting Analyst
Apr 16, 2023 • 11:07 ET • 4 min read
Pablo Lopez Minnesota Twins MLB
Photo By - USA TODAY Sports

The Twins rolled into Yankee Stadium this weekend and took two games from the Yankees, only to see the home team respond with a convincing 6-1 victory on Saturday. Now, New York will look to secure the series split on Sunday with its ace on the hill in Gerrit Cole.

Without further ado, let’s break down Twins vs. Yankees in our MLB picks and predictions for Sunday, April 16.

Twins vs Yankees odds

Twins vs Yankees predictions

The Minnesota Twins’ acquisition of Pablo Lopez this winter might have been the most slept-on addition of the offseason. The right-hander has followed up a stellar 2022 which saw him post a 3.75 ERA in grand fashion here in 2023 with three excellent starts.

Lopez has struck out a ridiculous 36.6% of batters he’s faced this season, which puts him in the Top 7% of all pitchers, and he’s coupled that with another year of walking guys less often than the league average and just three runs charged to his name in 14 2/3 innings.

The righty’s affinity for the punchout has him in an excellent spot against the New York Yankees, who rank seventh-worst in strikeout rate. His ability to limit walks will help him keep traffic off the bases against a team which loves to reach via the free pass.

Gerrit Cole is on the other side of this duel and has an even better matchup against a Twins side which is striking out at the fourth-highest clip in baseball. You just couldn’t script a better situation for the veteran, and with that I’m grabbing the Under here.

Both pitchers have struck out guys at over a 30% clip, and both have limited the damage in the power department. Against two all-or-nothing offenses, they will feast. 

My best bet: Under 7 (-110 at Caesars)

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Twins vs Yankees moneyline analysis

The Yankees opened up here around -165 favorites, and that’s exactly where they’re sticking at the moment, with some books moving them to -170. DraftKings is reporting that 88% of the moneyline bets have come in on New York, and it has commanded a whopping 97% of the handle.

So, there’s a clear side where the public and the pros are aligned. I’d tend to agree when you consider the Yankees are actually a bit better at making contact here, and will have the stronger pitcher.

While Lopez’s numbers have been sublime, too, we should consider that he faced the Royals, Marlins and White Sox to get here. The Yankees will not only represent a step up in competition, they will represent a massive one. I think the Yankees are clearly the side you want to take here.

Twins vs Yankees Over/Under analysis

There’s actually been a little movement towards the Over here, with the line opening at seven runs and around even money to hit the Over before a 10-cent move to make it a -110 bet. That’s likely because DraftKings is reporting that 66% of bets on the total and 71% of the handle is on the Over.

While I agree that both teams can sock the ball – and the Yankees are clearly a very strong team with a .202 ISO to rank third in baseball – I think Lopez is a little bit better than we’re giving him credit for here. Surely no one likes the Twins’ offense against Cole, so the public is likely banking on Lopez crashing back to Earth. I wouldn’t bet on that here.

Twins vs Yankees game info

Location: Yankee Stadium, Bronx, NY
Date: Sunday, April 16, 2023
First pitch: 1:35 p.m. ET
TV: Bally North, YES

Twins vs Yankees betting preview

Starting pitchers

Pablo Lopez (1-0, 1.35 ERA): Now 27, Lopez comes over from the Marlins after throwing 180 innings last season in 32 starts. In addition to being one of the most durable arms in the league, he’s kept his numbers very steady for the last three years, posting an ERA (and expected ERA) under four runs yet again in 2022.

Gerrit Cole (3-0, 1.40 ERA): The veteran started off the season with six shutout innings against the Giants only to work backwards in his next two outings, allowing one to the Phillies and two to the Guardians. Still, while he struck out only three pesky Cleveland hitters, his strikeout rate sits at 31%.

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The Under is 8-1-2 in the Twins’ last 11 games after allowing five or more runs in their previous game. Find more MLB betting trends for Twins vs. Yankees

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Kenny Ducey - Covers
Betting Analyst

Kenny Ducey has worked in sports media for more than 10 years and began his journey as a credentialed reporter with Fordham University's WFUV Sports before moving on to Sports Illustrated. There, he wrote about baseball, basketball, and tennis - twice covering the NBA Finals.

He's been in the betting space for seven years, and has established himself as a top expert in MLB and tennis handicapping with brands like Tennis Channel, NBC Sports, and DraftKings. He's also been a frequent guest on betting shows such as MLB's Bettor's Eye and Tennis Bets Live.

Kenny has a knack for identifying underappreciated pitchers and tennis players as moneyline underdogs and credits his unique data analysis and hours of watching sports as the biggest reasons for success through the years. His best advice to bettors? Watch the games, trust your eye, and always question the public narrative.

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