Grizzlies vs Clippers Prediction, Picks & Odds for Tonight’s NBA Game

Kawhi Leonard and the Los Angeles Clippers are at full strength and finally clicking on all cylinders, and we expect Los Angeles to stay hot on its home floor against Memphis.

Kenny Ducey - Betting Analyst at Covers
Kenny Ducey • Betting Analyst
Mar 21, 2025 • 17:05 ET • 4 min read
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This article contains predictions for an old game!

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Kawhi Leonard Los Angeles Clippers NBA
Photo By - Imagn Images. Los Angeles Clippers forward Kawhi Leonard.

Now healthy, the LA Clippers have prevailed in six of their last seven games heading into tonight's matchup against the Memphis Grizzlies.

With Memphis missing key pieces, my Grizzlies vs. Clippers predictions break down why Los Angeles will continue its winning ways.

Read more in my NBA picks for Friday, March 20.

Grizzlies vs Clippers prediction

My best bet: Clippers -7 (-110 at bet365)

My analysis
Although the Memphis Grizzlies offense has managed to stay afloat without Ja Morant, more injuries have since come their way. 

They’re now playing without Brandon Clarke, putting additional pressure on an already shaky frontcourt in terms of rebounding — and they may also be without Desmond Bane on top of it all.

Meanwhile, the Los Angeles Clippers continue to dazzle on offense. They’re finally healthy, and they enter Friday as the top mid-range offense in the league this month. For Memphis, the loss of Bane would put the Grizzlies in an even more precarious spot defensively given he and Clarke have done an excellent job in limiting opponents’ success on jumpers.

Against an offense that has been this efficient, scoring the ball will be paramount to keeping things close, and that would seem to take a massive hit with Clarke and Bane sidelined. When Morant has been off the floor, Memphis has seen nearly a five-point increase in its 3-point shooting frequency, which is tough news considering the Clippers continue to stop the 3-pointer at a formidable rate — ranking eighth this month.

I don’t see any avenue to success in this one for Memphis, which is taking fewer shots at the rim without Morant on the floor and will need to take a high volume of looks inside the restricted area if it wants to exploit LA's lone soft spot.

With the battle on the glass-drawing level due to the injuries and Memphis looking average defensively, take the Clippers to pull away tonight. 

Grizzlies vs Clippers same-game parlay

Clippers -6.5

Kawhi Leonard Over 9.5 assists and rebounds

James Harden Over 3.5 threes

Memphis has allowed the 11th-most rebounds to opposing power forwards this season and the fifth-most dimes. Kawhi Leonard is averaging 10 combined assists and rebounds in his last six games and has come home on this line in four of those nights.

The Grizzlies rank outside the top 10 in terms of attempts allowed this month and just 27th in 3-point defense, something that gets even trickier with Morant off the floor.

The biggest beneficiary should be James Harden, who went 5-for-13 from outside the last time these two teams met. Harden has now shot 38.3% from distance over his last eight games, and he's hit this number in three of his last five starts.

Learn how to bet a same-game parlay with these helpful tips and strategies.

Cash your ML bets quicker with bet365's early win payout

Take advantage of the early win payout at bet365, where any pre-game NBA moneyline bet gets paid out as a winner if your team goes up by 20+ points!

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Grizzlies vs Clippers odds

Grizzlies vs Clippers live odds

Grizzlies vs Clippers opening odds

  • Spread: Memphis +6.5 (-110) | Los Angeles -6.5 (-110)
  • Moneyline: Memphis +220 | Los Angeles -270
  • Over/Under: Over 231 (-110) | Under 231 (-110)

Odds courtesy of bet365.

Grizzlies vs Clippers spread and Over/Under analysis

  • The spread has climbed as high as 7.5 points but hasn’t moved significantly from its opening line, currently sitting at seven.
  • The Clippers have taken on 57% of the bets and 58% of the handle wagered on the spread.
  • The Over saw some love early, with the total twice hitting 231.5, but it has since dipped to 230.
  • 61% of the tickets and 85% of cash are on the Over.

Grizzlies vs Clippers trend

Memphis has hit the game total Over in 23 of its last 34 away games (+10.90 Units / 29% ROI). Find more NBA betting trends for Grizzlies vs. Clippers.

How to watch Grizzlies vs Clippers

Location Intuit Dome, Inglewood, CA
Date Friday, 3-21-2025
Tip-off 10:30 p.m. ET
TV NBA TV

Grizzlies vs Clippers latest injuries

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Kenny Ducey - Covers
Betting Analyst

Kenny Ducey has worked in sports media for more than 10 years and began his journey as a credentialed reporter with Fordham University's WFUV Sports before moving on to Sports Illustrated. There, he wrote about baseball, basketball, and tennis - twice covering the NBA Finals.

He's been in the betting space for seven years, and has established himself as a top expert in MLB and tennis handicapping with brands like Tennis Channel, NBC Sports, and DraftKings. He's also been a frequent guest on betting shows such as MLB's Bettor's Eye and Tennis Bets Live.

Kenny has a knack for identifying underappreciated pitchers and tennis players as moneyline underdogs and credits his unique data analysis and hours of watching sports as the biggest reasons for success through the years. His best advice to bettors? Watch the games, trust your eye, and always question the public narrative.

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