South Carolina vs Missouri Prediction, Picks & Odds for Tonight's College Basketball Game

Caleb Grill and the Missouri Tigers are hungry to get back into the win column and should do so with ease vs. hapless South Carolina, as our college basketball betting picks explain.

Rohit Ponnaiya - Betting Analyst at Covers.com
Rohit Ponnaiya • Betting Analyst
Feb 25, 2025 • 14:00 ET • 4 min read

NCAAB

Match starts: 3 hrs
MIZZ
51 %
SCAR
49 %
EXPERT PICK - SPREAD
Missouri -12.5 (-110) Missouri -12.5 (-110)
Read Analysis
Missouri Tigers NCAAM Caleb Grill
Photo By - Imagn Images. The Missouri Tigers' Caleb Grill in NCAAM action.

The No. 14 Missouri Tigers host the South Carolina Gamecocks in NCAA basketball action on Tuesday night. 

The Gamecocks just snapped a 13-game losing streak, but my South Carolina vs. Missouri predictions expect them to come crashing back to reality tonight. Here are my best free college basketball picks for this SEC battle on February 25.

South Carolina vs Missouri prediction

My best bet
Missouri -12.5 (-110 at bet365)

My analysis
The South Carolina Gamecocks are coming off an upset win at home against Texas, but that was their first win in conference play all season. Meanwhile, the Missouri Tigers are fresh off a road loss to Arkansas, which was a letdown spot following a huge win against No. 6 Alabama. 

Mizzou has a finely-tuned attack that is sixth in the country in adjusted offensive efficiency per KenPom. The Tigers have been even better at home, where they average 86.8 points per game and rank 10th in effective field goal percentage (59%). 

Their ability to score inside and out while taking care of the ball should ensure success against South Carolina, which has surrendered 80+ points in five of seven road games versus SEC foes. 

The Tigers have been vulnerable in their own end. During conference play, they are eighth in the SEC in adjusted defense and 12th out of 16 teams in opponent 2-point percentage (52.5%). That said, the Gamecocks don't have the firepower to take advantage of that weakness. 

South Carolina is dead-last in the conference in adjusted offense and 2-point percentage (46.9%). The Gamecocks are also 288th in the country in turnover rate (18.4%) with that number ticking up to 21.1% in SEC play.

The Tigers are 28th in the country in opponent TO rate (20.4%) and will be able to force turnovers and turn them into quick points in transition. Look for them to pull away and cruise to a comfortable win in a bounce-back spot here. 

South Carolina vs Missouri same-game parlay (SGP)

Missouri -12.5

Caleb Grill Over 13.5 points

Collin Murray-Boyles Over 7.5 rebounds

Caleb Grill has scored 15+ points in seven of his last 11 games. He's also significantly more efficient at home, where he shoots 53.4% from the floor while draining three treys per game at a 50% clip. He should shoot the lights out against a South Carolina squad that is allowing conference foes to shoot 38.5% from deep.

One of the few areas where the Gamecocks have an advantage in this matchup is on the glass, where they are one of the top defensive rebounding teams in the SEC. 

Sophomore forward Collin Murray-Boyles is South Carolina's best player and he leads the school in points (15.7) and rebounds (8.5) per game. He has grabbed double-digits in rebounds in his last two games and should eclipse 7.5 rebounds against an up-tempo Mizzou side.

Learn how to bet a same-game parlay with these helpful tips and strategies.

Cash your ML bets quicker with bet365's early win payout

Take advantage of the early win payout at bet365, where any pre-game CBB moneyline bet gets paid out as a winner if your school goes up by 18+ points!

Learn more about this feature, and all of bet365's offerings, with our comprehensive bet365 review.

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South Carolina vs Missouri odds

South Carolina vs Missouri live odds

South Carolina vs Missouri opening odds

  • Spread: South Carolina +14.5 (-115) | Missouri -14.5 (-105)
  • Moneyline: South Carolina +700 | Missouri -1100
  • Over/Under: Over 147 | Under 147

Odds courtesy of bet365

South Carolina vs Missouri betting trend to know

The Tigers are 6-1 ATS in their last seven games at home while the Gamecocks are 0-5 SU and ATS in their previous five contests on the road. Find more college basketball betting trends for South Carolina vs. Missouri.

How to watch South Carolina vs Missouri

Location Mizzou Arena, Columbia, MO
Date Tuesday, 2-25-2025
Tip-off 9:00 p.m. ET
TV ESPNU

South Carolina vs Missouri key injuries

Not intended for use in MA.
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Betting Analyst

With a background playing soccer, rugby, and boxing, combined with a journalism degree, it's little surprise that Rohit gravitated towards the world of sports betting. He specializes in betting on UFC and college basketball, two sports where the eyeball test can tell you a lot more about matchups than any analytics. Rohit has years of experience handicapping NFL and NBA games as well as niche betting markets such as politics and Oscar odds. He's also the resident CFL expert and formerly hosted "The Chez and Ro Show" with former CFL star Davis Sanchez.

You can catch Rohit breaking down every UFC event with Joe Osborne on "P4P Picks" on the Covers YouTube channel and he also has regular appearances on "Before You Bet" with Joe. In addition, he's a regular guest on "By The Book" on the Monumental Sports Network and makes guest appearances on VSIN's "The Handle" and CBS Sports.

Rohit primarily makes his bets at bet365, which offers a wide variety of prop markets, but also has accounts at several others so he can shop around for the best prices. For Rohit, bankroll management is key. He believes you should never bet what you can't afford to lose and maximize those few betting opportunities where books misprice a line.

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