After three weeks of high drama, the Colorado Buffaloes take their media circus to Eugene to face off against No. 10 Oregon. College football odds have tabbed the Ducks as -21 point home favorites, with the total sitting at an absurd 70 points.
This game is essentially make or break for the Buffaloes, as a lopsided loss would send them crashing out of the Top 25 and derail the hype train once and for all.
What about if they win, you ask? Well, I'm not sure the Twitter X servers are strong enough to handle that outcome.
Whatever plans you have on Saturday afternoon, cancel them, because this is a game you're going to want to watch.
We've already broken down the matchup in our Colorado vs. Oregon picks, so let's dive into the player props and give you my best college football picks for the Saturday afternoon affair.
Colorado vs Oregon Week 4 prop picks
- Sanders Under 335.5 passing yards
- Nix Over 2.5 TD passes
- Weaver anytime TD
Picks made on September 22, 2:00 p.m. ET.
Read full analysis of each pick.
Colorado vs Oregon Week 4 odds
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Best Colorado vs Oregon Week 4 prop picks
Prop bet #1: Limiting Sanders
Cometh the hour. Cometh the man.
At least that's what Deion Sanders wants you to believe of his son, the Colorado Buffaloes quarterback, Shedeur Sanders.
Sanders showed great poise last week vs. Colorado State, driving them down the field with the game (and season) on the line.
His performances over the first three weeks have thrust him up the Heisman Trophy odds board, but the climb stops here.
The Oregon defense will be ready for everything Sanders has to offer and then some. It ranks inside the Top 45 in defending the pass, giving up a paltry 158.7 yards through the air. Without Travis Hunter on the offense, Sanders' passing options will be limited to either Joe Horn Jr. or Xavier Weaver. Both have 25+ catches on the season, but the Ducks boast some highly skilled shutdown corners.
We know this game is going to be played at a breakneck pace, but the Oregon D will stand strong and limit what Sanders is able to do through the air.
Shedeur Sanders prop: Under 335.5 passing yards (-135 at DraftKings)
Prop bet #2: Bo knows touchdowns
On the other side of the football, how can we ignore Oregon's quarterback Bo Nix?
He's got the Ducks offense firing on all cylinders, averaging 58 points per game, and sitting fourth in the country in total yards and seventh in passing yards. He's not afraid of any throw and he gets everyone involved, something that's going to give the Buffaloes defense fits.
The Buffaloes defense is not good. This has been talked about in length over the first three games of the season. They can't stop anyone and they can't get off the field on third down. Nix is going to have a field day throwing against this porous defense and if we expect the Ducks to sniff their team total of 45.5, Nix is going to throw touchdown passes.
He's thrown at least three in two of the three games, and after Saturday afternoon, he'll have done so in three of four.
Bo Nix prop: Over 2.5 TD passes (-140 at DraftKings)
Prop bet #3: Leave it to Weaver
While Sanders may not throw for 340 yards, the Colorado Buffaloes are not going to get shut out in this game.
Without Hunter in the lineup on offense, Sanders is going to look to the guys he knows and trusts to make plays and that's Horn Jr. and Weaver.
We'll take our chances with a Weaver anytime TD in this game at a great -105 price.
Weaver has caught at least six balls in each game and is coming off back-to-back games with a touchdown.
Sanders trusts him and will force-feed him the ball every chance he gets.
Xavier Weaver prop: Anytime TD (-105 at DraftKings)
Not intended for use in MA.
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