Seahawks vs Lions Odds, Picks, and Predictions Week 2: Don't Let Week 1 Results Fool You

The Detroit Lions host the Seattle Seahawks in Week 2 of NFL action on Sunday.

The Lions entered this season with their highest expectations in years and lived up to that billing in their season opener when they knocked off the reigning Super Bowl champion Chiefs.

Meanwhile, the Seahawks opened their season with an ugly 30-13 loss to the Rams despite entering that contest as 4-point home favorites.

NFL odds have the Lions installed as 5.5-point home favorites for Sunday with the Over/Under at 47.5. Here are my best Seahawks vs. Lions NFL picks for September 17.

Seahawks vs Lions odds

Seahawks vs Lions predictions

This line looks like an overreaction to Week 1 when the Detroit Lions edged the defending Super Bowl champs and the Seattle Seahawks got creamed at home by the Rams.

There's plenty of reason to think both results were outliers. The Lions pass defense looked extremely vulnerable against Kansas City and they were fortunate that Chiefs receivers had a whopping eight drops — with many of those coming on crucial third down plays. 

That really shouldn't be that surprising. Although Detroit head coach Dan Campbell wants to embrace a philosophy of running the ball and tough defense, they were just 31st in the league in defensive EPA per play last year. Sure, the Lions upgraded their porous secondary by signing safety C.J. Gardner-Johnson and cornerback Cameron Sutton but this is still a stop unit with plenty of holes and will likely be just as bad against the run. 

The Seahawks are coming off an embarrassing offensive display against the Rams where Geno Smith had just 112 passing yards and averaged 4.3 yards per attempt. However, the veteran is coming off a Pro Bowl season where he completed 69.8% of his passes for 4,282 yards and 30 touchdowns. 

Granted, Smith is likely due for some regression after a career year but he should still be much better than he was in Week 1, especially with the weapons he has surrounding him. DK Metcalf and Tyler Lockett are one of the best wide receiver duos in the league and running back Kenneth Walker III looks poised for a big year after eclipsing the 1,000-yard mark as a rookie. 

The biggest concern is Seattle's offensive line with right tackle Abraham Lucas on the IR and left tackle Charles Cross unlikely to suit up due to a toe injury. However, having a week to prepare for their absence puts the offense in a better position to succeed than last Sunday when the backups were thrust into the lineup in the third quarter.

In addition, the Lions were 23rd in the league in pressure rate and Patrick Mahomes had the longest average time in the pocket in Week 1, so they might not be able to take advantage of that weakness.

The Lions have a promising squad but offensive coordinator Ben Johnson likes to control the clock by establishing the run and throwing short which will make it tough for them to blow out opponents.

Expect the Seahawks' explosive offense to keep them in this contest and grab the away team with the points. 

My best bet: Seahawks +5.5 (-112 at DraftKings)

Seahawks vs Lions same-game parlay

Seahawks +5.5 (-125)

David Montgomery Over 58.5 rushing yards (-110)

Jared Goff Under 0.5 interceptions (-185)

+700 at bet365

The Lions spent a Top-15 pick on running back Jahmyr Gibbs but last week indicated that they don't expect him to be a workhorse. Free agent acquisition David Montgomery ended up carrying the rock 21 times for 74 yards against the Chiefs and the 224-pound bruiser will likely continue to see a heavy workload in this run-focused offense. 

Goff has thrown 359 consecutive passes without an interception — the third-longest streak in NFL history. He hasn't thrown a pick in his last 10 games and should stay mistake-free against a Seahawks defense that knocked down just a single pass last week. 

Learn how to bet a same-game parlay with these helpful tips and strategies.

Seahawks vs Lions spread and Over/Under analysis

The look-ahead line before the season began had the Lions installed as 3-point faves but after Week 1, that number re-opened at -5.5.

That line has bounced around a bit, going as high as -6 and now sitting as low as -4.5 at some books. The Over/Under has also seen plenty of movement, dropping 3.5 points from the opening number of 50.5. 

The Seahawks made the playoffs last year before getting smoked by the 49ers in the Wild Card round. They are just 1-9 against the spread in their last 10 games and will need better much better play in the trenches (on both offense and defense) if they want to see postseason action again.

They entered the season with their win total at just 7.5 (Over at -110) while the Lions' win total was at 10.5 (Over -125), a number they haven't surpassed since 2014.

Detroit has gone 9-2 SU and ATS in its last 11 games and really turned things around after an ugly 1-6 start to their 2022 campaign. If the Lions want to take the next step, they'll need their defense to do a better job of stopping the run and generating more pressure on opposing QBs.

Seahawks vs Lions betting trend to know

The Lions have cashed their team total Over in eight of their last 10 games at home (+5.60 units / 45% ROI). Find more NFL betting trends for Seahawks vs Lions.

Seahawks vs Lions game info

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