The NFL is back!
The NFL odds for the opening week are now hitting the board, starting with the defending champion Philadelphia Eagles hosting the Dallas Cowboys to kick off the season on Thursday night football.
The Eagles opened as touchdown favorites, and that's just one of many intriguing games on the slate for Week 1.
NFL Week 1 Odds
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Cowboysvs  Eagles |
-7 |
+250 -310 |
46.5 |
|
|
 -3 |
-155 +130 |
44.5 |
 Steelersvs  Jets |
-2.5 |
-130 +110 |
41.5 |
 Giantsvs  Commanders |
-7.5 |
+270 -340 |
45.5 |
 Buccaneersvs  Falcons |
-2.5 |
-142 +120 |
47.5 |
 Panthersvs  Jaguars |
-3.5 |
+140 -166 |
45.5 |
 Dolphinsvs  Colts |
-1.5 |
+100 -120 |
45.5 |
 Raidersvs  Patriots |
-3.5 |
+145 -175 |
43.5 |
 Bengalsvs  Browns |
-4.5 |
-205 +170 |
44.5 |
 Cardinalsvs  Saints |
-3.5 |
-192 +160 |
43.5 |
 49ersvs  Seahawks |
-1.5 |
|
45.5 |
 Titansvs  Broncos |
-7.5 |
+295 -375 |
43.5 |
 Lionsvs  Packers |
-1.5 |
-102 -108 |
47.5 |
 Texansvs  Rams |
-3.5 |
+145 -175 |
44.5 |
 Ravensvs  Bills |
-1.5 |
+102 -122 |
51.5 |
 Vikingsvs  Bears |
-1.5 |
+102 -122 |
48.5 |
NFL Week 1 odds - marquee matchups
The full NFL schedule has officially been released, and the defending champion Eagles will host division rival Dallas to kick off the season.
Dallas upgraded its offense by adding George Pickens to join CeeDee Lamb and Dak Prescott, while the Eagles are poised for another Super Bowl run with a roster that's mostly intact from last year's loaded squad.
The spread was first posted at Eagles -7, while the total hit the board at 46.5.
The Kansas City Chiefs and Los Angeles Chargers follow up on Friday in Sao Paulo, Brazil, while the Ravens and Bills meet again in Orchard Park on Sunday Night Football.
To wrap up the Week 1 action, the Chicago Bears will host the Minnesota Vikings.
Covers NFL betting tools
NFL Week 1 odds - biggest storylines
While the world waits (again) for a decision from Aaron Rodgers, there are bigger storylines that should get plenty of attention ahead of Week 1.
The Kansas City Chiefs and Los Angeles Chargers will renew their rivalry in Sao Paulo, Brazil, while the Buffalo Bills and Baltimore Ravens will meet in a rematch of the 2025 AFC Divisional game.
Elsewhere, the Detroit Lions will take on the Green Bay Packers at Lambeau Field, and Cam Ward will make his NFL debut at Mile High Stadium in Denver.
More NFL betting analysis
- Aaron Rodgers’ record vs. every NFL team
- Patrick Mahomes’ record vs. every NFL team
- Russell Wilson’s record vs. every NFL team
- Josh Allen’s record vs. every NFL team
- Lamar Jackson’s record vs. every NFL team
Get a head start on your NFL bets!
Looking for our favorite early picks for NFL spread, total, and moneyline odds? Check out our best free NFL picks from the Covers staff!
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