The 2021 NFL schedule hits double digits in Week 10 with the season passing the midway mark. Oddsmakers are locked in, with more than two months of data fueling their weekly power ratings, point spreads and totals.
Regardless of the week, the sharpest NFL betting tip is always to find the best odds for your opinion. That means jumping into action early into the week or waiting for the market to move to the number you want.
We help you plan that attack, with our NFL Week 10 best spread and total to bet now and the best lines to bet later.
Week 10 bet now, bet later picks
- Carolina Panthers at Arizona Cardinals (-9.5): Bet Now
- Kansas City Chiefs at Las Vegas Raiders (+2.5): Bet Later
- Atlanta Falcons at Dallas Cowboys (Over 52): Bet Now
- Tampa Bay Buccaneers at Washington Football Team (Under 51.5): Bet Later
Click on each pick to jump to the full analysis.
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Carolina Panthers at Arizona Cardinals (-9.5): Bet Now
Arizona came away with a very impressive performance in Week 9, taking down the 49ers without top offensive weapons QB Kyler Murray and WR DeAndre Hopkins. That pair is expected back in action for Week 10 when the Cardinals welcome the stumbling Panthers to the desert.
Bookies opened Arizona as low as -9.5 (-114) while others hung -10 (-110) as their opener. If you can get the Cards below the key number, grab it as fast as you can. But even if the entire market has moved to Arizona -10 by the time you read this (it goes up Sunday night), that’s a pretty solid buy since this spread will likely end up on the other side of -10.
Carolina was blasted 24-6 by New England at home in Week 9, suffering its fifth loss in the past six outings despite returning RB Christian McCaffrey to the fray. The offensive line took a hit with the loss of center Matt Paradis for the season and could also be without T Cameron Erving. That’s bad news facing an Arizona pass rush that scored five sacks in the win over San Francisco on Sunday.
Kansas City Chiefs at Las Vegas Raiders (+2.5): Bet Later
The Raiders had a rough week, starting with the disturbing Henry Ruggs accident and ending with a bad loss at New York. Las Vegas returns home for a Sunday Night Football showdown with AFC West rival Kansas City in Week 10.
The Chiefs looked terrible in a 13-7 win over the Aaron Rodgers-less Packers, getting out-yarded by a Jordan Love-led Green Bay attack. Kansas City’s once-mighty offense has produced a grand total of only 36 points in the past three outings and the defense still leaves plenty of questions for bettors, who have cashed in only two bets in KC’s nine games this season.
Oddsmakers opened the Raiders as 2.5-point home pups with the vig at EVEN money/Kansas City -2.5 (-120), which would indicate a move to Vegas +3 if early action shows up on the Chiefs. Sure, the Raiders road loss in East Rutherford was bad, but just slightly worse than Kansas City’s ugly home win over the Cheeseheads. If you like the Silver and Black, wait for the field goal – or more – on Sunday night.
Atlanta Falcons at Dallas Cowboys (Over 52): Bet Now
The lookahead line for this matchup had a total of 51 points before Week 9’s result. And, even after Dallas laid an egg versus Denver at home (30-16 – with those 16 points coming in garbage time), the official opener was hung at 52 points and the juice is leaning toward the Over. If you’re buying into a high-scoring finish, get the Over now.
The Falcons offense continues to improve, putting up 27 points in a win over New Orleans and owning an EPA per play of + 0.102 since Week 4 – sixth highest in the NFL. Defensively, Atlanta is on the other end of that scale and has topped the total in four of its five games during that span.
The Cowboys are much better than their Week 9 showing would indicate and it looks like early money is investing in a return to form for Dak Prescott & Co. Dallas’ defense had the curtain pulled back, allowing 30 points to a pop-gun Broncos attack and now ranks 25th in passing yards against – just in time for an ATL aerial attack that ranks fourth in EPA per dropback since Week 4.
Tampa Bay Buccaneers at Washington Football Team (Under 51.5): Bet Later
This rematch of the NFC Wild Card Round hit the board with a total of 51.5 – a slight uptick from the lookahead number of 50.5 despite both teams enjoying a bye in Week 9. Online shops started adjusting the juice on the Over, moving from flat -110 to -115 quickly Sunday night.
Tampa Bay ranks No. 1 in points scored and has played Over in five of its eight games this season, but the week off should help the Bucs gets some bodies back in the secondary – a unit that’s been decimated since the start of the schedule. Top corners Carlton Davis and Sean Murphy-Bunting are expected to suit up in Week 10.
Washington’s offense was showing some fight earlier in the year but has fallen off a cliff in the past four games, watching its offensive EPA per play sink from +0.042 in the opening four games to -0.092 in the last four outings. However, the WFT defense is starting to find its form, most notably the pass rush which has 12 of its total 19 sacks in the past four games (1-3 OU).
It appears as if this total will climb up a touch, so if you like a lower-scoring finish between the Bucs and Hogs, hold off and see how tall the total will go before pulling the trigger.
