NFL Odds Week 15: Lines & Spreads For Every Game

Week 15 opens with an NFC West clash between the Los Angeles Rams and San Francisco 49ers, where the injury-plagued Niners are slim favorite on the look-ahead line.

Jared Hochman - Content Manager at Covers.com
Jared Hochman • Content Manager
Dec 4, 2024 • 14:07 ET • 8 min read
NFL Week 15 odds Isaac Guerendo
Photo By - Imagn Images. Pictured: 49ers RB Isaac Guerendo carries the ball in NFL action.

NFL odds Week 15

Matchup Spread Moneyline Over/Under
Rams Rams
vs
49ers 49ers
49ers -3 Rams +130
49ers -155
47
Bengals Bengals
vs
Titans Titans
Titans +4 Bengals -190
Titans  +160
49
Chiefs Chiefs
vs
Browns Browns

Browns +6.5 Chiefs -300
Browns +240
44.5
Ravens Ravens
vs
Giants Giants
Giants +13 Ravens -800
Giants +550
44.5
Cowboys Cowboys
vs
Panthers Panthers
Panthers +1.5 Cowboys -125
Panthers +105
44
Jets Jets
vs
Jaguars Jaguars
Jaguars +3 Jets -160
Jaguars +135
40.5
CommandersCommanders
vs
Saints Saints
Saints +3.5 Commanders -180
Saints +150
48
Dolphins Dolphins
vs
Texans Texans
Texans -2.5 Dolphins +120
Texans -140
46.5
Steelers Steelers
vs
Eagles Eagles
Eagles -4.5 Steelers +170
Eagles -205
45.5
Bills Bills
vs
Lions Lions
Lions -2.5 Bills -120
Lions -140
51.5
Colts Colts
vs
Broncos Broncos
Broncos -4.5 Colts +170
Broncos -205
43
Patriots Patriots
vs
Cardinals Cardinals
Cardinals -6.5 Patriots +240
Cardinals -300
45
Buccaneers Buccaneers
vs
Chargers Chargers
Chargers -3 Buccaneers +130
Chargers -155
46.5
Packers Packers
vs
Seahawks Seahawks
Seahawks +3 Packers -155
Seahawks +130
46.5
Bears Bears
vs
Vikings Vikings
Vikings -5.5 Bears +200
Vikings -245
42.5
ROAD Falcons
vs
Raiders Raiders
Raiders +3 Falcons -180
Raiders +150
44.5

Lines as of 12-4

The Week 15 NFL odds offer us plenty of intriguing storylines and point spreads to sift through. 

The festivities kick off on Thursday with an NFC West clash between the Rams and 49ers, and Sunday's action wraps up with Packers at Seahawks, while a double dip on Monday sees the Bears visit the Vikings and the Raiders host the Falcons. 

Rams vs 49ers odds (Thursday, 8:15 p.m. ET, Amazon Prime)

Puka Nacua
Imagn Images. Pictured: Rams WR Puka Nacua makes a catch vs. the Philadelphia Eagles..

Opening line

Opening line analysis coming soon!

Also see: full Thursday Night Football odds

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Bengals vs Titans odds (Sunday, 1:00 p.m. ET, FOX)

Joe Burrow
Imagn Images. Pictured: Bengals QB Joe Burrow throws a pass against the Pittsburgh Steelers.

Opening line

Opening line analysis coming soon!

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Chiefs vs Browns odds (Sunday, 1:00 p.m. ET, CBS)

Jerry Jeudy
Imagn Images. Pictured: Browns WR Jerry Jeudy scores a touchdown against the Denver Broncos.

Opening line

Opening line analysis coming soon!

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Ravens vs Giants odds (Sunday, 1:00 p.m. ET, CBS)

Derrick Henry
Imagn Images. Pictured: Ravens RB Derrick Henry rushes through Philadelphia Eagles cornerback Eli Ricks' tackle attempt.

Opening line

Opening line analysis coming soon!

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Cowboys vs Panthers odds (Sunday, 1:00 p.m. ET, FOX)

Bryce Young
Imagn Images. Pictured: Panthers QB Bryce Young throws a touchdown pass against the Tampa Bay Buccaneers.

Opening line

Opening line analysis coming soon!

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Jets vs Jaguars odds (Sunday, 1:00 p.m. ET, FOX)

Breece Hall
Imagn Images. Pictured: Jets RB Breece Hall runs with the ball against the Seattle Seahawks.

Opening line

Opening line analysis coming soon!

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Commanders vs Saints odds (Sunday, 1:00 p.m. ET, FOX)

Jayden Daniels
Imagn Images. Pictured: Commanders QB Jayden Daniels throws a touchdown pass over Tennessee Titans LB Kenneth Murray Jr.

Opening line

Opening line analysis coming soon!

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Dolphins vs Texans odds (Sunday, 1:00 p.m. ET, CBS)

Nico Collins
Imagn Images. Pictured: Texans WR Nico Collins runs with the ball after a catch against the Jacksonville Jaguars.

Opening line

Opening line analysis coming soon!

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Steelers vs Eagles odds (Sunday, 4:25 p.m. ET, FOX)

Saquon Barkley
Imagn Images. Pictured: Eagles RB Saquon Barkley reacts after QB Jalen Hurts scores a touchdown against the Cincinnati Bengals.

Opening line

Opening line analysis coming soon!

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More NFL betting analysis


Bills vs Lions odds (Sunday, 4:25 p.m. ET, CBS)

James Cook
Imagn Images. Pictured: Bills RB James Cook celebrates scoring a touchdown against the San Francisco 49ers.

Opening line

Opening line analysis coming soon!

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Colts vs Broncos odds (Sunday, 4:25 p.m. ET, CBS)

Courtland Sutton
Imagn Images. Pictured: Broncos WR Courtland Sutton makes a catch against the Cleveland Browns.

Opening line

Opening line analysis coming soon!

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Patriots vs Cardinals odds (Sunday, 4:25 p.m. ET, CBS)

Trey McBride
Imagn Images. Pictured: Cardinals TE Trey McBride fights off a tackle of Minnesota Vikings S Harrison Smith and LB Blake Cashman.

Opening line

Opening line analysis coming soon!

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Buccaneers vs Chargers odds (Sunday, 4:25 p.m. ET, FOX)

Baker Mayfield
Imagn Images. Pictured: Buccaneers QB Baker Mayfield hands off to RB Bucky Irving against the Carolina Panthers.

Opening line

Opening line analysis coming soon!

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Packers vs Seahawks odds (Sunday, 8:20 p.m. ET, NBC)

Geno Smith
Imagn Images. Pictured: Seahawks QB Geno Smith throws the ball as New York Jets defenders tackle him.

Opening line

Opening line analysis coming soon!

Also see: full Sunday Night Football odds

BACK TO TOP

Bears vs Vikings odds (Monday, 8:00 p.m. ET, ABC)

Sam Darnold
Imagn Images. Pictured: Vikings TE Johnny Mundt celebrates his touchdown with QB Sam Darnold.

Opening line

Opening line analysis coming soon!

Also see: full Monday Night Football odds

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Falcons vs Raiders odds (Monday, 8:30 p.m. ET, ESPN)

Bijan Robinson
Imagn Images. Pictured: Falcons RB Bijan Robinson runs against Los Angeles Chargers S Tony Jefferson.

Opening line

Opening line analysis coming soon!

Also see: full Monday Night Football odds

Best NFL bets this week

Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!

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Jared Hochman Content Manager at Covers.com
Content Manager

Before Jared Hochman joined the Covers team in 2020, he worked for newspaper outlets such as the Chronicle Herald and The Coast, worked in marketing for SkipTheDishes and Vivid Seats, and previously ran a magazine. A journalism graduate from the University of King's College in, Halifax, N.S., "Hoch" brings more than a decade of experience in sports betting, having worked as a freelance handicapper, making appearances on Monumental Sports Network and the Sharp 600 podcast, and now also filling in occasionally as host of Covers' NHL Puck Props. 

Awarded Covers' company MVP for 2023, Jared is an avid bettor of MLB, NFL, NHL, and NBA, while also wagering on some soccer and WNBA. His best advice for sports bettors? Price shop — something he does daily across 10 different sportsbook apps.

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