Chicago @ Houston preview

Chi. White Sox at Houston

Last Meeting ( Jun 15, 2013 ) Chi. White Sox 3, Houston 4

The streaky Houston Astros shoot for their fourth straight victory Sunday when they continue their four-game series against the visiting Chicago White Sox. Houston completed a perfect six-game road trip June 3 and split its next two contests before dropping six in a row. The Astros ended their skid with a triumph at Seattle on Wednesday and have captured the first two games of this set, both by one run.

Jason Castro and Chris Carter belted solo home runs in the fourth inning Saturday and Houston went on to post a 4-3 victory. It was the third straight loss for Chicago and second on its nine-game road trip. The White Sox have struggled mightily away from home, losing 11 of their last 12.

TV: 2:10 p.m. ET, Comcast SportsNet Chicago, CSN Houston

Santiago will be making his seventh overall start this season and second in a row. The 25-year-old, who is 2-2 with a 2.67 ERA as a starter, allowed two runs - one earned - and four hits over 6 1/3 innings in a victory over the Oakland Athletics on June 9. Santiago made a relief appearance against Houston on June 8, 2012, yielding two runs in 1 1/3 frames.

Keuchel is coming off a tough loss at Seattle on Monday in his seventh start of 2013, as he allowed only two runs - one earned - and seven hits in six innings. The 25-year-old has been impressive over his last three starts, going 2-1 with a 1.89 ERA. Keuchel, who leads the American League with a 2.63 groundball-to-flyball ratio, will be making his first career appearance against the White Sox.

WALK-OFFS

1. Opponents are hitting .210 against Santiago in his starts.

2. The Astros are facing a left-handed starter in every contest of a four-game series for the first time since 1989.

3. Houston has won seven of its last nine meetings with Chicago.

PREDICTION: Astros 5, White Sox 3