San Diego @ San Francisco preview

Last Meeting ( Sep 13, 2016 ) San Diego 6, San Francisco 4

Winners of their first nine meetings against San Diego this season, the San Francisco Giants are now struggling to record a single victory against the lowly Padres. The Giants look to bounce back from one of their worst losses of the season Wednesday in the finale of a three-game series against visiting San Diego, which scored five runs in the ninth inning of Tuesday’s 6-4 win.

San Francisco has lost five in a row to San Diego, which rallied Tuesday against relievers Hunter Strickland and Steven Okert, who were seeking to fill the role vacated by deposed closer Santiago Casilla. Right fielder Hunter Pence is 15-for-28 during his seven-game hitting streak for the Giants, who are four games behind the Dodgers in the National League West and just a half-game ahead of the New York Mets for the first wild-card spot in the NL. Giants third baseman Eduardo Nunez has missed the last two games because of back tightness but could return for the series finale against San Diego, which saw rookie second baseman Ryan Schimpf blast his 19th home run in Tuesday’s win. Padres third baseman Yangervis Solarte is 12-for-32 during his eight-game hitting streak and has seven RBI during his last four games.

TV: 3:45 p.m. ET, FSN San Diego, CSN Bay Area (San Francisco)

PITCHING MATCHUP: Padres RH Luis Perdomo (7-9, 5.89 ERA) vs. Giants LH Madison Bumgarner (14-8, 2.61)

Perdomo suffered his second straight loss after allowing four runs on eight hits and one walk over 6 2/3 innings Friday against Colorado. The 23-year-old rookie offered a glimpse of his potential Aug. 28 when he recorded his first complete game and threw 99 pitches in a 3-1 victory over Miami. A Rule 5 draft pick from St. Louis, Perdomo allowed three runs in 4 2/3 innings against the Giants on July 16 and owns a 6.48 ERA in three games against San Francisco.

Bumgarner aims for his 100th career victory after yielding four runs over six innings in a no-decision Friday against Arizona. The four-time All-Star has been dominant in his last four starts against the Padres at AT&T Park, going 3-0 with a 1.19 ERA and 38 strikeouts against four walks. Derek Norris is 10-for-33 with a home run against Bumgarner, who owns a 10-6 record and 3.24 ERA in 26 career games (25 starts) against San Diego, including 2-1 with a 2.91 ERA in three outings this season.

WALK-OFFS

1. The Giants are 7-14 in one-run games since the All-Star break.

2. 1B Wil Myers is one home run shy of becoming the first Padres hitter to post a season with at least 25 homers, doubles and steals.

3. San Francisco 1B Brandon Belt (illness) was scratched from Tuesday’s lineup and is listed as day-to-day.

PREDICTION: Giants 8, Padres 3