College Basketball Picks and March Madness Best Bets

Free College Basketball Expert and Computer Picks For Every Game March 21, 2026

Louisville Cardinals logo LOU @ Michigan State Spartans logo MSU Sat, Mar 21 • 2:45 PM ET
2 Expert Picks
Points
JK Jaxon Kohler o12.5 Points (-105)
Best Odds
Pick made: yesterday
Jason Logan image
Jason Logan
Senior Betting Analyst

Jaxson Kohler is an inside-out threat for MSU. He’s able to score inside but also stretch the defense with his 3-point shooting. The Spartans will need to knock down some triples to match UL’s perimeter points. Kohler had 12 points in just 26 minutes in the Round of 64 blowout and scored 15 or more in the final three games of Big Ten play.

MoneyLine
Michigan State Spartans logo MSU (-185)
Best Odds
Pick made: yesterday
Jason Logan image
Jason Logan
Senior Betting Analyst

The Spartans can bully UL, especially down low. The Cardinals gave up 44 points in the paint to the Bulls and rolled out the red carpet to the rim in the home stretch of ACC play. Protecting the paint is an issue for Louisville, Its allowed an average of 38 PITP per game over its last 13 outings. Michigan State has capable bodies to battle in the paint, a deeper bench, and fresher legs. Getting MSU shorter than two bucks seems like a steal.

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TCU Horned Frogs logo TCU @ Duke Blue Devils logo DUKE Sat, Mar 21 • 5:15 PM ET
3 Expert Picks
Assists
Cameron Boozer logo Cameron Boozer o4.5 Assists (-155)
Best Odds
Pick made: 3 hours ago
JD Yonke image
JD Yonke
Betting Analyst

Cameron Boozer leads the Blue Devils with a 26% assist rate, and averaged 5.6 assists over the final five games before the NCAA Tournament. With point guard Caleb Foster still absent, the onus falls on Boozer to generate looks.

3 Point FG
Isaiah Evans logo Isaiah Evans o2.5 3 Point FG (-125)
Best Odds
Pick made: 20 hours ago
Jason Logan image
Jason Logan
Senior Betting Analyst

Evans was 2 for 8 from beyond the arc on an off outing for the Blue Devils vs. Siena. Duke gets right against a TCU defense that allows too many high-quality 3-point looks. The sophomore guard is very active from outside, taking seven or more triples in each of his past seven games. He’s connected for three or more 3-balls in five of those outings. 

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Texas A&M Aggies logo TXAM @ Houston Cougars logo HOU Sat, Mar 21 • 6:10 PM ET
1 Expert Pick
Points
Kingston Flemings logo Kingston Flemings o16.5 Points (-115)
Best Odds
Pick made: 12 hours ago
Douglas Farmer image
Douglas Farmer
Betting Analyst

Added pace courtesy of Texas A&M should create opportunities for Kingston Flemings to gash his way to the basket. His taking 12 shots against overmatched Idaho should serve as a statement to the bracket that this NCAA Tournament may be a Flemings showcase.

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Dayton Flyers logo DAY @ UNC Wilmington Seahawks logo UNCW Sat, Mar 21 • 7:00 PM ET
1 Expert Pick
Total
Dayton Flyers logo UNC Wilmington Seahawks logo u138.5 (-110)
Best Odds
Pick made: 3 hours ago
Ed Scimia image
Ed Scimia
Betting Analyst

Dayton ranks 32nd in the nation in adjusted defensive efficiency, while UNC Wilmington has been outstanding defensively down the stretch. With neither team looking to run the floor and the Flyers having hit the Under in eight of their last nine games, I'm backing the Under tonight.

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Texas Longhorns logo TEX @ Gonzaga Bulldogs logo GONZ Sat, Mar 21 • 7:10 PM ET
1 Expert Pick
Spread
Texas Longhorns logo TEX +6.5 (-110)
Best Odds
Pick made: yesterday
Rohit Ponnaiya image
Rohit Ponnaiya
Betting Analyst

The Longhorns biggest weakness are their 3-point defense (270th in opponent 3PT%) and tendency to foul (307th in opponent FT rate). However, the Bulldogs attempt threes at one of the lowest rates in the country while ranking just 277th in FT rate. On the other side of the floor, Gonzaga has impressive defensive stats but that's puffed up by weak competition in the West Coast Conference. The Zags struggled to contain more athletic teams earlier in the season and Texas has a highly-efficient offense. The Zags don't have any wings capable of locking up Dailyn Swain and don't have a rim protector to contain Matas Vokietaitis.

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VCU Rams logo VCU @ Illinois Fighting Illini logo ILL Sat, Mar 21 • 7:50 PM ET
2 Expert Picks
MoneyLine
VCU Rams logo VCU (+400)
Best Odds
Pick made: 4 hours ago
Jason Ence image
Jason Ence
Betting Analyst

March is defined by your performance in the clutch, and Illinois has lost six of its seven games this season decided by five or fewer points. The common denominator in those games was an inability to get stops, especially against talented guards. VCU has those in spades.

Spread
VCU Rams logo VCU +11.5 (-116)
Best Odds
Pick made: 20 hours ago
Douglas Farmer image
Douglas Farmer
Betting Analyst

VCU has gone 17-1 outright since its season was on the brink, not to mention winning the Atlantic-10 Tournament and going 3-1 ATS in the postseason. Of course the Rams came back from 14 down late in the second half of the first round; they are relentless.

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Vanderbilt Commodores logo VAN @ Nebraska Cornhuskers logo NEB Sat, Mar 21 • 8:45 PM ET
1 Expert Pick
Spread
Vanderbilt Commodores logo VAN -2.0 (-110)
Best Odds
Pick made: 22 hours ago
Douglas Farmer image
Douglas Farmer
Betting Analyst

Nebraska ran through Troy in part thanks to a 26-10 advantage in points in the paint, to be expected against a mid-major opponent. The Vanderbilt Commodores will not yield such chances, one of the best interior defenses in the SEC.

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Liberty Flames logo LIB @ Nevada Wolf Pack logo NEV Sat, Mar 21 • 9:00 PM ET
1 Expert Pick
Points
VW Vaughn Weems o15.5 Points (-105)
Best Odds
Pick made: 31 minutes ago
Jason Ence image
Jason Ence
Betting Analyst

Vaughn Weems is primed to have a big game against the Flames. He’s averaging 16.6 points over his last eight games, and has made seven baskets at the rim in each of his last two.


That will likely be his primary focus against a Liberty team whose starting lineup averages a hair over 6-foot-2 and struggles to rebound. 


Weems has four offensive boards in the last two contests, leading to second-chance points and FT attempts.


This is a perfect spot for him to continue to assert himself and get whatever he wants at the rim. 

 

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High Point Panthers logo HP @ Arkansas Razorbacks logo ARK Sat, Mar 21 • 9:45 PM ET
2 Expert Picks
MoneyLine
High Point Panthers logo HP (+500)
Best Odds
Pick made: 4 hours ago
Jason Ence image
Jason Ence
Betting Analyst

High Point is aggressive in terms of jumping the passing lanes and generating points in transition. The Panthers also operate at a very high tempo, which could be problematic for an Arkansas team that has little depth due to injuries to Karter Knox and Nick Pringle.

Points
TB Trevon Brazile o14.5 Points (-110)
Best Odds
Pick made: 23 hours ago
Rohit Ponnaiya image
Rohit Ponnaiya
Betting Analyst

High Point is 43rd in the country in adjusted tempo while ranking 175th in opponent 2PT% (51.6%) despite playing an extremely weak schedule. The Panthers were torched by Wisconsin's guards in the first round and were fortunate the Badgers didn't have any offensive threats in their frontcourt to expose High Point's lack of size. Arkansas forward Trevon Brazile can do exactly that. Brazile is coming off a game where he scored 19 points despite shooting just 1-7 from deep. He has scored 16+ points in five of his last six contests and we know Calipari trusts him in big games with how he played in last year's tourney run.

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Miami (FL) Hurricanes logo MIA @ Purdue Boilermakers logo PUR Sun, Mar 22 • 12:10 PM ET
1 Expert Pick
Total
Miami (FL) Hurricanes logo Purdue Boilermakers logo o147.5 (-110)
Best Odds
Pick made: 2 hours ago
Rohit Ponnaiya image
Rohit Ponnaiya
Betting Analyst

The Boilermakers have the highest rated offense in KenPom history and shoot a sizzling 38.5% from deep. They'll torch a Miami defense that ranks 319th in opponent 3PT% (37.3%) since the start of the new year. That said, Miami can exploit Purdue's man-to-man defense through pick-and-roll action and scoring in the paint. The Canes rank 34th in the country in 2PT% (56.9%) while the Boilermakers are 340th in 2-point defense (56.9%) since January 1. With both offenses perfectly built to exploit the other team's defensive weakness, take the Over. Especially with KenPom and Bart Torvik projecting 153 and 154 points respectively.

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St. John's Red Storm logo SJU @ Kansas Jayhawks logo KU Sun, Mar 22 • 5:15 PM ET
2 Expert Picks
Points
Darryn Peterson logo Darryn Peterson o21.5 Points (-113)
Best Odds
Pick made: 1 hours ago
Jason Logan image
Jason Logan
Senior Betting Analyst

Peterson had 28 points with just under six minutes left Friday and then didn’t touch the ball for the remainder of the game. He still set a season high in attempts, with 24 FGAs over 37 minutes and was efficient with 11 makes – four coming from beyond the arc. He finished with just two made free throws but I expect him to pick up points from the foul line against the Johnnies. He had attempted at least six FTs in each of the previous four game. I’m not going to get cute, I’ll play the best player on the floor Over his points prop.

MoneyLine
Kansas Jayhawks logo KU (+125)
Best Odds
Pick made: 4 hours ago
Jason Ence image
Jason Ence
Betting Analyst

Both teams defend exceptionally well, but the Jayhawks present an athleticism that can match the Red Storm. The presence of Flory Bidunga also means that Rick Pitino can’t utilize Zuby Ejiofor as a disruptor on the perimeter, as he did against Northern Iowa.

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Tennessee Volunteers logo TENN @ Virginia Cavaliers logo UVA Sun, Mar 22 • 6:10 PM ET
1 Expert Pick
Total
Tennessee Volunteers logo Virginia Cavaliers logo u137.5 (-116)
Best Odds
Pick made: 22 minutes ago
Chris Hatfield image
Chris Hatfield
Betting Analyst

Virginia does a good job essentially stopping all that Tennessee wants to run. The Vols are a heavy post frequency team and UVA ranks in the 97th percentile nationally against post ups. They also slow down some other core tenants of the Tennessee offense like premeriter cuts. Meanwhile on the other side, you don’t have to worry about UVA scoring early buckets against an elite transition defens

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UCLA Bruins logo UCLA @ UConn Huskies logo CONN Sun, Mar 22 • 8:45 PM ET
2 Expert Picks
Total
UCLA Bruins logo UConn Huskies logo u136.0 (-116)
Best Odds
Pick made: an hour ago
Jason Logan image
Jason Logan
Senior Betting Analyst

Both UCLA and UConn thrive in the halfcourt, playing with patience that ticks deep into the shot clock. There’s a ton of motion, away screens and off-ball movement, which takes time to set up. Neither is an explosive 3-point attack, nor do they thrive on fastbreaks or tempo. Sub-140 totals were 1-5 Over/Under through the first two days of the NCAA Tournament. Going back to last year’s Big Dance, sub-140 totals have gone Under in 13 of 18 games.

MoneyLine
UCLA Bruins logo UCLA (+145)
Best Odds
Pick made: 4 hours ago
Jason Ence image
Jason Ence
Betting Analyst

UCLA forces a turnover on 18.2% of possessions, ranking 82nd nationally. Since February 1, UConn has a turnover rate of 17.6%, which ranks 271st nationally. In a game of limited offensive trips, that could send the Huskies packing in the opening weekend. 

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Texas Tech Red Raiders logo TTU @ Alabama Crimson Tide logo ALA Sun, Mar 22 • 9:45 PM ET
1 Expert Pick
MoneyLine
Texas Tech Red Raiders logo TTU (-127)
Best Odds
Pick made: 3 hours ago
Chris Hatfield image
Chris Hatfield
Betting Analyst

Texas Tech puts a chokehold on Alabama in transition with a national best defense in that area and will keep the Tide from scoring regularly in the halfcourt. Nate Oats schemes well enough for a long portion of the game, but eventually the damn breaks and Alabama can’t defend well enough on the other end. 

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