49ers vs Bills Prediction, Picks, Prop Bets For December 01, 2024

SF vs BUF Picks

There are no Expert or Computer Picks for this matchup at the moment.

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NFL Picks Page

SF vs BUF Consensus Picks

Spread

72% picking Buffalo

28% 28%

72% 72%

Total Picks SF 168, BUF 422

Total

63% picking San Francisco vs Buffalo to go Over

63% 63%

37% 37%

Total PicksSF 234, BUF 139

SF vs BUF Props

Player

Prop

Season Avg.

Best Odds

Projection Rating

San Francisco Trends

The San Francisco 49ers have hit the 3Q Game Total Over in 14 of their last 19 games (+7.75 Units / 32% ROI)

Over

Under

Game Line - Total - 3rd Period

The San Francisco 49ers have hit the 1H Moneyline in 15 of their last 22 games (+2.80 Units / 5% ROI)

BUF

Game Line - MoneyLine - 1st Half

The San Francisco 49ers have hit the 2H Game Total Over in 12 of their last 16 games (+7.63 Units / 44% ROI)

Over

Under

Game Line - Total - 2nd Half

The San Francisco 49ers have covered the 1Q Spread in 7 of their last 10 away games (+4.00 Units / 35% ROI)

BUF

Game Line - Spread - 1st Period

The San Francisco 49ers have hit the 4Q Game Total Over in 6 of their last 8 away games (+3.60 Units / 39% ROI)

Over

Under

Game Line - Total - 4th Period

The San Francisco 49ers have only hit the Team Total Over in 7 of their last 21 games (-10.90 Units / -40% ROI)

The San Francisco 49ers have only hit the 3Q Game Total Under in 5 of their last 19 games (-9.80 Units / -47% ROI)

Over

Under

Game Line - Total - 3rd Period

The San Francisco 49ers have only hit the 3Q Moneyline in 8 of their last 19 games (-8.35 Units / -22% ROI)

BUF

Game Line - MoneyLine - 3rd Period

The San Francisco 49ers have only hit the 2Q Moneyline in 9 of their last 19 games (-7.25 Units / -18% ROI)

BUF

Game Line - MoneyLine - 2nd Period

The San Francisco 49ers have only covered the 3Q Spread in 7 of their last 19 games (-6.70 Units / -31% ROI)

BUF

Game Line - Spread - 3rd Period

Buffalo Trends

The Buffalo Bills have hit the 2Q Game Total Over in 14 of their last 18 games (+10.60 Units / 50% ROI)

Over

Under

Game Line - Total - 2nd Period

The Buffalo Bills have hit the Team Total Over in 9 of their last 10 games at home (+8.25 Units / 70% ROI)

The Buffalo Bills have hit the Moneyline in 16 of their last 21 games (+10.55 Units / 20% ROI)

BUF

Game Line - MoneyLine - Full Game

The Buffalo Bills have hit the Game Total Over in 10 of their last 11 games at home (+8.90 Units / 74% ROI)

Over

Under

Game Line - Total - Full Game

The Buffalo Bills have hit the 2H Moneyline in 5 of their last 8 games at home (+3.90 Units / 22% ROI)

BUF

Game Line - MoneyLine - 2nd Half

The Buffalo Bills have hit the 3Q Moneyline in 9 of their last 18 games (+5.15 Units / 18% ROI)

BUF

Game Line - MoneyLine - 3rd Period

The Buffalo Bills have covered the 3Q Spread in 12 of their last 20 games (+3.60 Units / 15% ROI)

BUF

Game Line - Spread - 3rd Period

The Buffalo Bills have only hit the 2H Game Total Over in 5 of their last 15 games (-5.89 Units / -36% ROI)

Over

Under

Game Line - Total - 2nd Half

The Buffalo Bills have only hit the 4Q Moneyline in 6 of their last 18 games (-4.95 Units / -17% ROI)

BUF

Game Line - Spread - 4th Period

The Buffalo Bills have only hit the 3Q Game Total Under in 8 of their last 20 games (-5.55 Units / -24% ROI)

Over

Under

Game Line - Total - 3rd Period

The Buffalo Bills have only hit the 1H Moneyline in 6 of their last 11 games at home (-4.85 Units / -19% ROI)

BUF

Game Line - MoneyLine - 1st Half

The Buffalo Bills have only hit the 1Q Game Total Over in 9 of their last 21 games (-4.60 Units / -19% ROI)

Over

Under

Game Line - Total - 1st Period

The Buffalo Bills have scored first in 2 of their last 5 games (-3.90 Units / -43% ROI)

The Buffalo Bills have only hit the 1Q Moneyline in 8 of their last 21 games (-4.30 Units / -13% ROI)

BUF

Game Line - MoneyLine - 1st Period

The Buffalo Bills have only hit the 4Q Game Total Under in 9 of their last 20 games (-3.55 Units / -15% ROI)

Over

Under

Game Line - Total - 4th Period

SF vs BUF Top User Picks

There are no User Picks for this match up at the moment. Visit our Team Leaders to see all User picks.

San Francisco Team Leaders

Rank	Leader	L10	Units
1	Leonoodle	10-0-0	+5000
2	ThreeTops	10-0-0	+5000
3	Mexicali72	8-0-0	+4000
4	Aleana2000	8-2-0	+3900
5	bigguy69	8-2-0	+3900
6	HeCo21	8-2-0	+3630
7	Monsmon45	8-2-0	+3600
8	Hesonfie24	8-1-1	+3450
9	bobhay	8-1-1	+3450
10	loulo13	8-2-0	+3400
All 49ers Money Leaders

Buffalo Team Leaders

Rank	Leader	L10	Units
1	beloborg151	9-1-0	+4450
2	ancianioe	9-1-0	+3950
3	RPJSTEELER	8-2-0	+3900
4	Abbyllar	8-2-0	+3900
5	TDRO1	8-2-0	+3900
6	purple_stars	7-0-1	+3500
7	johnnyjbd24	8-1-0	+3450
8	Brayy_Wyatt	8-2-0	+3400
9	johnnyjanes	8-2-0	+3400
10	bluorch158	8-2-0	+3220
All Bills Money Leaders

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San Francisco @ Buffalo Picks & Props

SF vs BUF Picks

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SF vs BUF Consensus Picks

72% picking Buffalo

63% picking San Francisco vs Buffalo to go Over

SF vs BUF Props

SF vs BUF Trends

The San Francisco 49ers have hit the 3Q Game Total Over in 14 of their last 19 games (+7.75 Units / 32% ROI)

The San Francisco 49ers have hit the 1H Moneyline in 15 of their last 22 games (+2.80 Units / 5% ROI)

The San Francisco 49ers have hit the 2H Game Total Over in 12 of their last 16 games (+7.63 Units / 44% ROI)

The San Francisco 49ers have covered the 1Q Spread in 7 of their last 10 away games (+4.00 Units / 35% ROI)

The San Francisco 49ers have hit the 4Q Game Total Over in 6 of their last 8 away games (+3.60 Units / 39% ROI)

The San Francisco 49ers have only hit the Team Total Over in 7 of their last 21 games (-10.90 Units / -40% ROI)

The San Francisco 49ers have only hit the 3Q Game Total Under in 5 of their last 19 games (-9.80 Units / -47% ROI)

The San Francisco 49ers have only hit the 3Q Moneyline in 8 of their last 19 games (-8.35 Units / -22% ROI)

The San Francisco 49ers have only hit the 2Q Moneyline in 9 of their last 19 games (-7.25 Units / -18% ROI)

The San Francisco 49ers have only covered the 3Q Spread in 7 of their last 19 games (-6.70 Units / -31% ROI)

The Buffalo Bills have hit the 2Q Game Total Over in 14 of their last 18 games (+10.60 Units / 50% ROI)

The Buffalo Bills have hit the Team Total Over in 9 of their last 10 games at home (+8.25 Units / 70% ROI)

The Buffalo Bills have hit the Moneyline in 16 of their last 21 games (+10.55 Units / 20% ROI)

The Buffalo Bills have hit the Game Total Over in 10 of their last 11 games at home (+8.90 Units / 74% ROI)

The Buffalo Bills have hit the 2H Moneyline in 5 of their last 8 games at home (+3.90 Units / 22% ROI)

The Buffalo Bills have hit the 3Q Moneyline in 9 of their last 18 games (+5.15 Units / 18% ROI)

The Buffalo Bills have covered the 3Q Spread in 12 of their last 20 games (+3.60 Units / 15% ROI)

The Buffalo Bills have only hit the 2H Game Total Over in 5 of their last 15 games (-5.89 Units / -36% ROI)

The Buffalo Bills have only hit the 4Q Moneyline in 6 of their last 18 games (-4.95 Units / -17% ROI)

The Buffalo Bills have only hit the 3Q Game Total Under in 8 of their last 20 games (-5.55 Units / -24% ROI)

The Buffalo Bills have only hit the 1H Moneyline in 6 of their last 11 games at home (-4.85 Units / -19% ROI)

The Buffalo Bills have only hit the 1Q Game Total Over in 9 of their last 21 games (-4.60 Units / -19% ROI)

The Buffalo Bills have scored first in 2 of their last 5 games (-3.90 Units / -43% ROI)

The Buffalo Bills have only hit the 1Q Moneyline in 8 of their last 21 games (-4.30 Units / -13% ROI)

The Buffalo Bills have only hit the 4Q Game Total Under in 9 of their last 20 games (-3.55 Units / -15% ROI)

SF vs BUF Top User Picks

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