The Lions are coming off a rare poor performance at home, where they lost 27-24 to the Vikings. This is a get-right spot for them against a Washington team in turmoil. The Commanders have a below-average pass rush while their linebackers and secondary are among the worst in the NFL. Their offense was already struggling due to a slew of injuries at WR but they also just lost franchise QB Jayden Daniels to what looks like a serious injury. The Lions are third in the league in defensive DVOA and eighth in offensive DVOA. They'll be highly motivated to run up the score, given their Week 9 loss and their playoff loss to the Commanders in January.
This is a bounce-back spot for the Lions, and the Commanders could be without No. 1 quarterback Jayden Daniels after he sustained a left elbow injury that was serious enough for him to exit the Week 9 loss to the Seattle Seahawks. Of course, Washington also ranks 17th in defensive DVOA while allowing the sixth-highest EPA per play, so I expect the Detroit offense to have a big day and score enough points to cover the number.