The lawsuit, filed Tuesday in U.S. District Court in the group's hometown of Detroit, seeks unspecified damages.
The song is one of about 30 songs featured on "Guitar Hero Encore: Rocks the '80s." The band also is seeking an injunction that could take the best-selling game off store shelves.
A copyright claim is not the issue for the Romantics. The band's attorneys tell the Detroit Free Press for Thursday's edition that Activision properly secured permission to use "What I Like About You," allowing it to record a cover version.
But they say by creating an imitation so much like the Romantics' original, the California-based company infringed on the group's rights to its own likeness.
Activision representatives did not return calls for comment from the Detroit Free Press.