Cardinals vs Mariners Predictions, Picks, Odds: St. Louis Bats Win Slugfest in Seattle

With nothing special on the mound for either side, we're expecting a slugfest — but can Seattle's offense keep pace with the Cardinals if that's the case? Our MLB betting picks say no — find out why below.

Kenny Ducey - Betting Analyst at Covers
Kenny Ducey • Betting Analyst
Apr 21, 2023 • 15:11 ET • 4 min read
Nolan Arenado Paul Goldschmidt St. Louis Cardinals MLB
Photo By - USA TODAY Sports

Both pitchers have their flaws, but there’s one clear choice on Friday.

The Cardinals have been tearing the cover off the ball this season, but their pitching has let them down of late.

One of those starters will take the hill on Friday in the form of Steven Matz, but might he have some more success against a Mariners side that has lost three straight?

Let’s break down Cardinals vs. Mariners in our MLB picks and predictions below.

Cardinals vs Mariners odds

Cardinals vs Mariners predictions

Folks in Seattle are very excited about George Kirby’s future, but I’ve yet to see anything to convince me he’s destined to be more than a back-end arm.

The righty has never walked many batters, which is one of his strong suits, but his strikeout rate is down to 17.1% this season and he’s not exactly getting outs via contact.

Kirby’s ground ball rate is all the way down at 33.9% and his xwOBA on contact stands at .389, which is well higher than the league average. That has put his xERA all the way at 4.55 with a .310 expected batting average.

Simply put, there are plenty of reasons to love a very strong St. Louis Cardinals offense on Friday against Kirby. They’re third in wRC+ to this point and sporting a low 20.6% strikeout rate with a strong .167 Isolated Power.

St. Louis is doing it all while Seattle has graded out as a below-average offense and has been one of the worst in baseball vs. lefties.

We will get to Steven Matz in just a moment, but for now, let’s just settle on the fact that the Cardinals have the better offense and are in a great spot against the alleged better pitcher.

My best bet: Cardinals moneyline (+110 at Pinnacle)

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Cardinals vs Mariners moneyline analysis

Matz has been a bit lost this season, but he should be able to figure things out against a weak Seattle Mariners offense.

Seattle is 18th in hard-hit balls per swing and barrel rate and against lefties has a disastrous 76 wRC+ with a 7.6% walk rate and 25.3% strikeout rate. If you’re familiar with those metrics, you would know that all three are very poor numbers.

What has been Matz’s biggest issue to this point? Well, that’s a loaded question. He has a 49% hard-hit rate to this point with a 10.5% walk rate, which is a very lethal combination. On top of this, his strikeouts are down year-over-year.

The good news is that the Mariners don’t walk a lot vs. lefties (or righties, for that matter) and have been very poor when it comes to strikeouts and power. With that, I love Matz a lot more than Kirby — who has to face an excellent offense.

Cardinals vs Mariners Over/Under analysis

Ultimately, you’re out of your mind if you’re not siding with the Over here. This line respects Kirby a bit too much, and on the other side of things, while I'm a bigger fan of Matz’s here, it seems out of the question he makes it through this start unscathed.

After all, Matz has allowed 12 runs in 16 2/3 innings and really only looked good against the Pirates, who might have the worst offense in baseball. I don’t trust Seattle to keep up in a slugfest, but I do think this game turns into one.

Seattle’s power numbers aren’t great but they’re good enough to expect a homer or two. 

Cardinals vs Mariners game info

Location: T-Mobile Park, Seattle, WA
Date: Friday, April 21, 2023
First pitch: 10:10 p.m. ET
TV: MLB Network

Cardinals vs Mariners betting preview

Starting pitchers

Steven Matz (0-2, 6.48 ERA): The left-hander has made three starts, and his latest was the best of the lot. He worked 5 2/3 innings of two-run ball and allowed just three hits, though that did come with five walks. Matz did strike out six and has 17 Ks in 16 2/3 frames.

George Kirby (1-1, 3.78 ERA): The second-year prospect has calmed himself after yielding four runs on nine hits and walk over 4 1/3 in his first outing of the year against the Angels, giving up just three across his last two starts. He’s still lacking in the strikeout department with 12 in 16 2/3 innings.

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The Over is 4-0-1 in the Cardinals’ last five games. Find more MLB betting trends for Cardinals vs. Mariners

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Kenny Ducey - Covers
Betting Analyst

Kenny Ducey has worked in sports media for more than 10 years and began his journey as a credentialed reporter with Fordham University's WFUV Sports before moving on to Sports Illustrated. There, he wrote about baseball, basketball, and tennis - twice covering the NBA Finals.

He's been in the betting space for seven years, and has established himself as a top expert in MLB and tennis handicapping with brands like Tennis Channel, NBC Sports, and DraftKings. He's also been a frequent guest on betting shows such as MLB's Bettor's Eye and Tennis Bets Live.

Kenny has a knack for identifying underappreciated pitchers and tennis players as moneyline underdogs and credits his unique data analysis and hours of watching sports as the biggest reasons for success through the years. His best advice to bettors? Watch the games, trust your eye, and always question the public narrative.

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