College Football Week 10 Against the Spread Picks for the Biggest Games

The Week 10 college football odds are centered around a massive Big Ten showdown, with No. 4 Ohio State heading to Happy Valley to take on undefeated No. 3 Penn State.

I have college football picks for that matchup and much more below.

College football Week 10 picks against the spread

Matchup	Pick
Ohio State vs  Penn State	+3.5
Duke vs  Miami	+21
Mississippi vs  Arkansas	+7
Oregon vs  Michigan	-15
Florida vs  Georgia	+16.5
Louisville vs  Clemson	-10.5
Texas A&M vs  South Carolina	-2.5
Kentucky vs  Tennessee	-16.5

Lines courtesy of DraftKings as of 10-29.

CFB Week 10 ATS picks

Ohio State (-3.5) vs. Penn State: Penn State +3.5

While Penn State historically comes up short in games like this, nothing about the Buckeyes' performance against Nebraska instills the confidence you need to back them here.

Duke vs. Miami (-21): Duke +21

Not to suggest Duke will shut Miami down, but it's allowed more than 24 points just once in eight games this season. I'll take the points.

Mississippi (-7) vs. Arkansas: Arkansas +7

Give me the touchdown with the home team that beat Tennessee outright and had a fourth-quarter lead over Texas A&M at Kyle Field. 

Oregon (-15) vs. Michigan: Oregon -15

I might need three full touchdowns to consider jumping the fence to Michigan. Oregon rolls and moves to 9-0. 

Florida vs. Georgia (-16.5): Florida +16.5 

You'd think Georgia would start to roll after taking Texas in Austin, but Florida has covered in four straight and won as an outright underdog in two of those games.

Louisville vs. Clemson (-10.5): Clemson -10.5

If not for scheduling Georgia instead of a nobody in Week 1, Clemson would be ranked as high as Miami or even Penn State. Full steam ahead for Cade Clubnik & Co.

Texas A&M (-2.5) vs. South Carolina: Texas A&M -2.5

One of these teams should have beaten LSU, and the other actually did... by 15. Texas A&M gets the win and stays undefeated in SEC play.

Kentucky vs. Tennessee (-16.5): Tennessee +16.5

While acknowledging the concerns I still have for Tennessee's offense, Kentucky has scored 43 total points over its last three games against Vanderbilt, Florida, and Auburn (all losses). 

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