Ohio State vs Notre Dame Prediction, Picks & Best Bet for the CFP National Championship Game

While taking the points is tempting, Covers college football expert Andrew Caley has found another way to profit from Monday's National Championship game.

Andrew Caley - Senior Betting Analyst at Covers.com
Andrew Caley • Senior Betting Analyst
Jan 20, 2025 • 19:15 ET • 4 min read
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This article contains predictions for an old game!

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Composite of Will Howard (Ohio State) and Riley Leonard (Notre Dame)
Photo By - Imagn Images. Composite image of Ohio State QB Will Howard and Notre Dame QB Riley Leonard.

College Football is steeped in tradition. It’s part of what makes the sport so great, and this season culminates with two of the most storied programs, the Ohio State Buckeyes and the Notre Dame Fighting Irish, facing off for a national title, which kicks off at Mercedes-Benz Stadium in Atlanta at 7:30 p.m. ET.

My Ohio State vs. Notre Dame predictions highlight how the Irish will keep this natty close, which favors an Under bet.

Ohio State vs Notre Dame prediction and best bet

Ohio State vs Notre Dame moneyline prediction

Yes, Ohio State has looked outstanding, and head coach Ryan Day has done an excellent job of getting out of his own way. However, this is still a team that lost at home to Michigan as 20-point favorites.

Overlooked in the win over Texas is that Will Howard looked very average against a good Longhorns secondary. If you don’t think Notre Dame's elite pass defense can keep Howard in check, I don't know what to tell you. 

I’d much rather take a shot with a live underdog at +380 than lay the -375 with Ohio State.

Ohio State vs Notre Dame total prediction

The total in this national championship might be the most interesting odds of all. This total hit the board at 46.5 and despite seeing just 30% of the bets and 21% of the handle according to BetMGM, the number has still moved down to 45.5. That likely means there is some respected money on the Under.

Plus, this is a matchup of two elite defenses. Ohio State enters this game ranked first in the country in opponent EPA per play and fourth in defensive success rate. Meanwhile, Notre Dame ranks second and 10th in those categories respectively.

On top of that, The Irish rely a lot on running the football to generate offense, while at the same time having the best pass defense in the country. But while they take this away through the air, it can open things up on the ground for opponents.

Running and good defense sounds like an Under to me. Get this number quickly or you will have missed a key number.

My best bet
Under 45.5 (-110 at BetMGM)
Picks made at time of writing may not reflect live odds.

My analysis
We are spoiled with this College Football Playoff National Championship Game featuring a pair of blue bloods in the Ohio State Buckeyes and the Notre Dame Fighting Irish. However, it has been an interesting journey for both teams.

Ohio State began the season among the favorites to be here and win this national title, but some hiccups along the way allowed a little doubt to creep in. 

The Buckeyes lost to Oregon on the road back on Oct. 12, which in itself isn’t that egregious, but they followed that up with uninspiring wins over Nebraska and Penn State. Then there was the game against Michigan. 

OSU managed to flip a switch in the playoff, crushing Tennessee and Oregon in the first two rounds. Jeremiah Smith was a beast, and the defense has become what everyone thought it could become.

Speaking of that defense, this is a unit that leads the country in opponent EPA per play, scoring defense, and sack rate — and defensive coordinator Jim Knowles has been a rock star since a regular season matchup against Indiana.

That takes us to this matchup against Notre Dame. The Irish have quietly been the most consistent team in the country since a shocking loss to Northern Illinois back in Week 2. Since then, Notre Dame has notched 13 wins and 11 covers in a row — including impressive wins over Indiana, Georgia, and Penn State. 

The Irish do that thanks to an elite defense, and by running the football with Jeremiyah Love and quarterback Riley Leonard.

However, you can expect that Ohio State will commit to shutting down that Notre Dame running attack and for Leonard to beat the Buckeyes with his arm. That will be easier said than done.

Meanwhile, the Irish have the best pass defense in the country, leading the nation in EPA per dropback and defensive success rate on dropbacks. This will be key when it comes to shutting down Smith.

The true freshman phenom looked unstoppable in the first two rounds, but in the Cotton Bowl against Texas, the Longhorns said, “Anyone but him,” and locked him up for one catch and three yards. I expect the Irish will have a similar game plan in mind for the national championship.

Meanwhile, the Irish gave PSU QB Drew Allar fits in the Orange Bowl, holding him to 12-of-23 passing for 135 yards, and one of my biggest questions in this game is how Buckeyes QB Will Howard will handle the pressure Notre Dame can generate.

Howard has looked great at times this season, but that feels a little like a by-product of having great skill-position players around him, and teams that can pressure him have given him problems in the past.

Marcus Freeman knows if his team has a shot at the upset, it’s by shortening this game and limiting Ohio State possessions. To me, this all adds up to a low-scoring game, so give me the Under 45.5. 


Ohio State vs Notre Dame same-game parlay (SGP)

Under 45.5

Carnell Tate 4+ receptions

TreVeyon Henderson 50+ rushing yards

This may look like a pro-Ohio State same-game parlay, but it all stems from the excellence of this Notre Dame pass defense. From what I’ve watched on film, I believe the Irish can successfully limit this powerful Buckeyes offense. 

The Irish secondary is good enough to man up on the outside, but I also expect them to double and maybe even triple-team Jeremiah Smith at times, just like the Longhorns did in the Cotton Bowl. They won’t let Smith beat them, which means Will Howard will have to look elsewhere.

In that Cotton Bowl, he targeted Carnell Tate nine times, and Tate caught seven of them for 87 yards. Take Tate to record 4+ receptions in this natty final.

Then let’s close it out with Buckeyes’ RB TreVeyon Henderson to get 50+ rushing yards. This may be a hot take, but I think Henderson is a better back than running mate Quinshon Judkins. He averaged 7.3 yards per carry this season and always seems to show up in Ohio State’s biggest games.

Notre Dame will sell out to stop the pass, leaving holes for Henderson to run through. He’s hit this mark 12 times this season. Because of the combination of skill and game script, I like him to do it again.

Learn how to bet a same-game parlay with these helpful tips and strategies.

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More Ohio State vs Notre Dame picks from Covers


Ohio State vs Notre Dame odds

Ohio State vs Notre Dame live odds

Ohio State vs Notre Dame opening odds

  • Ohio State vs. Notre Dame spread: Notre Dame +9.5
  • Ohio State vs. Notre Dame moneyline: Ohio State -400, Notre Dame +300
  • Ohio State vs. Notre Dame Over/Under: 46.5

Odds courtesy of BetMGM

Ohio State vs Notre Dame spread and Over/Under analysis

  • This CFP National Championship spread opened with Notre Dame as 9.5-point underdogs. The spread remained there for a few days before dropping as low as 8. The consensus line is 8.5 as of Saturday afternoon, two and a half games before kickoff.
  • Notre Dame has been a great bet this season and has covered the spread in 11 consecutive games. But Ohio State has gone 6-2 ATS in its last eight overall. I would act now if you like the Buckeyes, I could see them getting a boost once more public money starts coming in as kickoff approaches.
  • The total hit the board at 46.5 and has come down one point to sit at 45.5.
  • This is another situation where if you like the Under I would act soon. BetMGM has reported just 21.5% of the handle on the total has been on the Under, yet the number has still come down.
  • According to our Covers Consensus tool, 62% of users are picking Notre Dame to cover the spread while 69% expect the national championship game to go Over the projected point total.

Ohio State vs Notre Dame betting trend to know

The Fighting Irish have covered the spread in their last 11 games (+11.00 Units . 90% ROI). Meanwhile, Ohio State has hit the game total Under in eight of their last 12 games (+3.60 Units / 27% ROI). Find more college football betting trends for Ohio State vs Notre Dame.

Ohio State vs Notre Dame game info

Location: Mercedes-Benz Stadium, Atlanta, GA
Date: Monday, 1-20-2025
Kickoff: 7:30 p.m. ET
TV: ESPN

Learn how to watch Ohio State vs. Notre Dame on cable and online.

Ohio State vs Notre Dame latest injuries

The National Championship is here and both the Ohio State Buckeyes and the Notre Dame Fighting Irish are relatively healthy heading into this title tilt.

Ohio State has no key injuries coming into this matchup. The Buckeyes did lose offensive lineman Josh Simmons and Seth McLaughlin earlier in the season, but they have been playing without them for several weeks.

Notre Dame is a little more banged up, as left tackle Anthonie Knapp is out with an ankle injury.

Meanwhile, the Irish are getting a boost on offensive. Wide receiver Beaux Collins, the team's second-leading receiver is listed as probable after suffering a calf injury in the Orange Bowl, while running back Jeremiyah Love isn’t listed on the injury report at all.

Ohio State vs Notre Dame weather

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Senior Betting Analyst

When his dreams of becoming the next Steve Nash died, all Andrew “Taco” Caley wanted to do was write about sports, something he’s been doing at Covers for more than a decade. A Journalism School grad from Holland College in Charlottetown, PEI, Andrew previously worked at The Chronicle Herald and Star Metro, but knew in his heart that his future lay in sports. He began at Covers as a news editor and has now done everything under the sun when it comes to content. His work has been seen on TSN, Sportsnet, VSiN, and CBS.

These days Andrew’s betting expertise is focused on his favorite teams – the Toronto Blue Jays and Toronto Raptors. He’s also an avid college football fan and bettor. He can’t be friends with you if you don’t appreciate a Service Academy Under. You can also call him Covers’ Sixth Man, as he regularly steps up to guest host Before You Bet and our MLB and NCAAF release shows.

The sportsbook where he does the bulk of his betting is bet365 thanks to its numerous prop betting options and competitive odds. His best advice? Find the balance between the numbers and what you see on the playing field. Then find the best price using multiple books. And don’t ask him where the nickname Taco comes from. It’s not an interesting story. Seriously.

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