A full Week 3 slate of college football action means a plethora of college football odds to tackle.
Among the week's key matchups are a handful of SEC showdowns, a trio of in-state rivalry games, and a fascinating SEC/Big Ten battle between No. 4 Alabama and Wisconsin. Those matchups highlight my best ATS college football picks below.
College football Week 3 picks against the spread
| Matchup | Pick |
|---|---|
 Arizona vs  Kansas State |
Kansas State -7.5 |
 Alabama vs  Wisconsin |
Wisconsin +16 |
 LSU vs  South Carolina |
South Carolina +7 |
 Memphis vs  Florida State |
Memphis +6.5 |
 Boston College vs  Missouri |
Missouri -16.5 |
 Oregon vs  Oregon State |
Oregon State +16.5 |
 Texas A&M vs  Florida |
Texas A&M -4.5 |
 Utah vs  Utah State |
Utah State +20.5 |
 UTSA vs  Texas |
Texas -35 |
 Georgia vs  Kentucky |
Georgia -24 |
 Colorado vs  Colorado State |
Colorado State +7.5 |
Lines courtesy of DraftKings as of 9-10.
CFB Week 3 ATS picks
Arizona vs. Kansas State (-7.5): Kansas State -7.5
Both teams needed comebacks to escape Week 2 with wins over clearly inferior opponents, but at least Kansas State was away from home and playing the better of the two opponents. If K-State can get ahead, this run game that ranks fourth in the country in yards per carry through two weeks should help the home team find separation.
Read our full Arizona vs. Kansas State predictions.
Alabama (-16) vs. Wisconsin: Wisconsin +16
Don't let the 42-16 final score against South Florida fool you, Alabama had a 1-point lead entering the final frame and was up just five points with six minutes remaining before piling it on late. Although Wisconsin has been far from dominant in its first two games, I'm inclined to take the points with the Badgers at home.
Read our full Alabama vs. Wisconsin predictions.
LSU (-7) vs. South Carolina: South Carolina +7
It's hard to have a ton of confidence in LSU after losing the opener to USC and needing a second-half push to find separation as a 46.5-point favorite against Nicholls State (23-21 early in the second half, won 44-21). And while LSU was duking it out with an FCS team, South Carolina was dominating Kentucky as a 9.5-point road underdog.
Read our full LSU vs. South Carolina predictions.
Memphis vs. Florida State (-6.5): Memphis +6.5
Florida State is the most disappointing team of the season thus far and has been an absolute nothingburger offensively with DJ Uiagalelei under center. The Seminoles will get back on track eventually, but laying 6.5 against a Memphis team that's covered two big numbers to start the season is not something I can stomach.
Read our full Memphis vs. Florida State predictions.
Boston College vs. Missouri (-16.5): Missouri -16.5
Boston College got a huge bump from taking down FSU in Week 1 and is now ranked No. 24 in the country... we'll see how long that lasts. Missouri has yet to give up a point this season, and while that will surely change on Saturday, it won't come at the expense of a third straight win and cover.
Oregon (-16.5) vs. Oregon State: Oregon State +16.5
Should anyone in the country feel worse about a 2-0 start than Oregon? The offensive line is worse, the run game is averaging less than 3.0 yards per carry, and the Ducks have had to scratch out two wins against teams they should handle with ease. Oregon State gave up just 179 total yards of offense to San Diego State last week and I'm happy to take the points in this rivalry game considering the Beavers have won the last two home editions outright.
Read our full Oregon vs. Oregon State predictions.
Texas A&M (-4.5) vs. Florida: Texas A&M -4.5
While Texas A&M's Week 1 loss to Notre Dame loses some shine after the Irish fell to Northern Illinois, I'm still bullish on A&M being solid in the SEC. The same can't be said for Florida, who tried to mask the smell of its Week 1 blowout loss to Miami with a 45-7 blowout of Samford. I'll lay the small number here.
Read our full Texas A&M vs. Florida predictions.
Utah (-20.5) vs. Utah State: Utah State +20.5
This is a sizable number, especially when you consider Cam Rising's injured hand and questionable tag for this game. We won't know his availability until... the game starts, and if he doesn't go, the offense will run through backup Isaac Wilson (Zach Wilson's brother). I'm staying away but will take the points if I have to.
UTSA vs. Texas (-35): Texas -35
I wouldn't think too hard about this. Texas covered a 34.5-point spread by 17.5 points in Week 1 (52-0 against Colorado State) and a 6.5-point spread by 12.5 points in Week 2 (31-12 over Michigan). Expect a similar data point in Week 3.
Read our full UTSA vs. Texas predictions.
Georgia (-24) vs. Kentucky: Georgia -24
You couldn't pay me to take the points here. Georgia has done what Georgia does, and as mentioned earlier, Kentucky is coming off an embarrassing 31-6 home loss to South Carolina. This will get ugly fast.
Colorado (-7.5) vs. Colorado State: Colorado State +7.5
Colorado State pushed Colorado to overtime as a 24.5-point road underdog a season ago, and we're getting a very similar matchup this time around minus the mountain of Deion Sanders momentum we had this time last year. Take the points with the home team and close your eyes.
Read our full Colorado vs. Colorado State predictions.
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