Conference play is starting to ramp up as we enter Week 4, and I'm back to make some point-spread college football picks for the biggest games on the college football odds board.
Among those are matchups between USC and Michigan, Utah and Oklahoma State, and Tennessee and Oklahoma. I give you the right side for each of those matchups below.
College football Week 4 picks against the spread
| Matchup | Pick |
|---|---|
 Illinois vs  Nebraska |
+10 |
 Marshall vs  Ohio State |
-40 |
 NC State vs  Clemson |
-20.5 |
 USC vs  Michigan |
-5.5 |
 UCLA vs  LSU |
+24.5 |
 Miami (OH) vs  Notre Dame |
-28 |
 Utah vs  Oklahoma State |
-2.5 |
 Tennessee vs  Oklahoma |
-7 |
 UL Monroe vs  Texas |
+44 |
 Baylor vs  Colorado |
-2 |
 Kansas State vs  BYU |
-7 |
Lines courtesy of DraftKings as of 9-17.
Record: 6-5 after Week 2.
CFB Week 4 ATS picks
Illinois vs. Nebraska (-10): Illinois +10
Perhaps this will be a true coming-out game for the Cornhuskers, but I would have liked to see them tested before giving them a 10-point edge against a Top 25 team. I'll take the points.
Marshall vs. Ohio State (-40): Ohio State -40
Ohio State has won its first two games by 46 and 56 points, and while Marshall will be a slight step up in competition, the Buckeyes will be rested and ready to roll after a bye in Week 3.
NC State vs. Clemson (-20.5): Clemson -20.5
With NC State's injured Grayson McCall likely out and true freshman CJ Bailey likely in, this could be a tough trip to Death Valley after needing to overcome an 11-point halftime deficit against Louisiana Tech in Week 3.
USC (-5.5) vs. Michigan: USC -5.5
Michigan announced it was switching back to Alex Orji for this Big Ten battle after Davis Warren threw three picks on Saturday. The defense and run game has been enough to control inferior teams, but I'm not sure that combination works against the new-look Trojans.
UCLA vs. LSU (-24.5): UCLA +24.5
UCLA got pummeled by Indiana on Saturday, but LSU is simply too sloppy to be trusted with a spread this large. I'll take the points.
Miami (OH) vs. Notre Dame (-28): Notre Dame -28
Notre Dame crushed Purdue by 59 points on Saturday. While that relieved some of the pressure following the Irish's Week 2 upset loss to Northern Illinois, I expect another desperate performance from the offense this weekend.
Utah (-2.5) vs. Oklahoma State: Utah -2.5
All signs point to Cam Rising being ready to play in what will be Utah's biggest test of the season to this point, and that's enough for me to lay this small number against a team that was down 21-7 and needed OT to beat Arkansas at home two weeks ago.
Tennessee (-7) vs. Oklahoma: Tennessee -7
Oklahoma may be 3-0, but it's far from a convincing 3-0, considering the Sooners were up just five points in the final frame against Tulane (won 34-19) and only beat Houston by four. I don't have those questions about Tennessee.
UL-Monroe vs. Texas (-44): UL-Monroe +44
Even with Quinn Ewers sidelined, these Texas spreads continue to grow to the point where it may be wise to look the other way. As good as Arch Manning was in relief, ULM is 2-0 straight up and 2-0 against the spread. The highlights won't come as easily, and the scoreline won't be as wide.
Baylor vs. Colorado (-2): Colorado -2
I'll lay this tiny number with the Buffs after dominating CSU on the road last week. The one time Baylor's defense was tested, it gave up 23 points in a half to Cam Rising before he left injured. Colorado can do something similar here.
Kansas State (-7) vs. BYU: Kansas State -7
Kansas State scored 31 unanswered points against Arizona on Friday in what was its most impressive performance thus far. BYU is 3-0 SU and ATS but hasn't played anyone near this level of competition. Give me the Wildcats.
Not intended for use in MA.
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