In a battle between two teams off to very different starts to the season, the 3-0 Oregon Ducks will host the 0-3 Arizona Wildcats on Saturday.
This will be the PAC-12 Conference opener for both squads. The Ducks are flying high and already have a win over Ohio State in the bag, while the Wildcats will be looking to stay out of the conference basement after an ugly start that includes a blowout loss to San Diego State. Will the Ducks be able to dominate and cover as 28-point favorites?
Find out with our free college football picks and predictions for Arizona vs. Oregon on September 23.
Arizona vs Oregon odds
Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.
This line has seen a half-point of movement, as Oregon opened as a 28-point fave but is sitting at -28.5 as of the time of this writing. The total opened at 58 and has been bet up to 59. Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full college football odds before placing your bets.
Arizona vs Oregon picks
Picks made on 9/23/2021 at 4:02 p.m. ET.
Click on each pick to jump to the full analysis.
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Arizona vs Oregon game info
• Location: Autzen Stadium, Eugene, OR
• Date: Saturday, September 25, 2021
• Time: 10:30 p.m. ET
• TV: ESPN
Arizona vs Oregon betting preview
Weather
Be sure to monitor the gametime conditions with our NCAA football weather info.
Key injuries
Arizona: Jamarye Joiner (Questionable).
Oregon: Anthony Brown QB (Probable), Kayvon Thibodeaux DE (Questionable), Patrick Herbert TE (Questionable), Sean Dollars RB (Questionable), Bram Walden OL (Questionable), Mase Funa LB (Probable), Keith Brown LB (Probable).
Find our latest NCAA football injury reports.
Betting trend to know
Arizona is 1-12 ATS in its last 13 games following a straight-up loss. Find more NCAA betting trends for Arizona vs. Oregon.
Arizona vs Oregon predictions
Oregon -28.5 (-110)
The Ducks are undoubtedly the vastly superior team in this matchup. They’ve already secured a victory on the road against Ohio State and have their sights set on a conference championship, and perhaps more. The Wildcats, meanwhile, are coming off a loss to Northern Arizona — an FCS school.
There was a lot of excitement surrounding the Jedd Fisch hire in the offseason, but that was mostly due to off-field pep. The on-field product has looked far from stellar, as they’re scoring only 16.3 points per game and have yet to find a win. And the Wildcats have not rebounded well coming off an ATS loss, as they are 0-4 in their last 4 games in that scenario.
Oregon, however, has been great in this spot, going 8-3 ATS in its last 11 games following an ATS loss.
While the Ducks have looked stellar thus far, they always have one surprising conference game where they unexpectedly lose — Cal and Oregon State last year, Arizona State in 2019, Arizona in 2018. Will this be the spot for their unsuspecting loss in 2021? All signs point to no.
This Wildcats team hasn’t proved that they can play consistently on either side of the football, and they're overmatched in nearly every facet of the game in this matchup. Kevin Sumlin left this program in need of a long overhaul and it’s going to take a lot of time before the Wildcats are competitive in this conference.
Under 59 (-110)
It’s pretty hard to consider an Over play right now with this Arizona team averaging 16.3 points per game and only 339.7 yards of total offense. The run game has been especially futile, as the Wildcats are averaging only 79.3 rushing yards per game on 2.9 yards per carry.
Their task won’t get any easier here against a solid Ducks defense. The numbers are a little misleading after allowing over 600 yards to Ohio State, but can you fault them for that? They’re still allowing only 19.7 points per game on the season.
The Wildcats have yet to find their guy at quarterback, as they’ve given three different signal callers time under center. It’ll likely help the Under here if they opt to play Jordan McCloud — who was inserted in the fourth quarter of last week's game — as he’s averaged only 6.7 yards per attempt in his career.
Oregon has little incentive to add on to the scoreboard late. It tends to lean conservative in its playcalling when it has a lead. The trends back that up, as the under is 7-3 in the Ducks' last 10 games as a home favorite.
Look for Oregon to build a comfortable lead early and then take its foot off the pedal in the second half.
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