Michigan State vs Northwestern Picks and Predictions: Wildcats Look for Big Ten Revenge

There is still uncertainty under center for the Spartans, but they can depend on a deep WR corps and an improved defense. Our picks and predictions break down whether that will be enough for MSU to upset favored Northwestern for a second straight year.

JD Yonke - Contributor at Covers.com
JD Yonke • Contributor
Sep 1, 2021 • 15:58 ET • 4 min read
Jalen Nailor Michigan State Spartans college football
Photo By - USA TODAY Sports

Big Ten conference action continues with a Week 1 showdown between the Michigan State Spartans and the Northwestern Wildcats.

Northwestern will look to build upon a strong 2020 season in which they finished 7-2 and claimed the Big Ten West division title. Aside from the Big Ten Championship Game, the only blemish on their record was a 29-20 defeat to the Spartans. They entered that matchup 5-0 only to fall vs. the slumping Spartans. The Wildcats will come out of the gates hungry in this spot, but will that be enough?

Check out our college football betting free picks and predictions for Michigan State vs. Northwestern on Friday, September 3 and find out.

Michigan State vs Northwestern game info

Location: Ryan Field, Everson, IL
Date: Friday, September 3, 2021
Time: 9:00 p.m. ET
TV: ESPN

Michigan State vs Northwestern odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

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Michigan State vs Northwestern betting preview

Weather

Be sure to monitor the gametime conditions with our NCAA football weather info.

Key injuries

Michigan State: No injuries to report.
Northwestern: Berkeley Holman WR (Probable), Cam Porter RB (Out), Zachary Franks OL (Out).
Find our latest NCAA football injury reports.

Betting trend to know

The road team is 14-3 ATS in the last 17 meetings between these two teams. Find more NCAA betting trends for Michigan State vs. Northwestern.

Against the spread (ATS) pick

The 2021 season will be a monumental test for Northwestern head coach Pat Fitzgerald. The Wildcats enter this contest returning only 34 percent of their production from last season, good for 126th in the country. In a season in which nearly every team returns a wealth of experience, they return only nine starters and will be one of the least experienced teams in the country.

Counting Fitzgerald out without a second thought would be a fool’s errand, however, as he has routinely frustrated bettors who discount his team’s chances. He’s earned the respect of college football bettors and for good reason. That being said, he has as tough of a task as any coach in the country this season.

The Wildcats do have several trends working in their favor, going 5-0 ATS in their last five home games and 8-1-1 ATS in their last ten games overall. However, this is a vastly different team in 2021.

Despite being a former five-star recruit, Northwestern’s new starting quarterback, Hunter Johnson, was last seen in 2019, when he completed only 46.3 percent of his passes and compiled an unseemly 1:4 touchdown to interception ratio. Running back Cam Porter, assumed to be the focal point of the offense this season, suffered a season-ending leg injury in mid-August. The defense also must replace the vast majority of their top performers.

The Spartans, meanwhile, will be hoping for improvement in year two under Mel Tucker after finishing with a 2-5 record a season ago. 

They return 17 starters and will rely on a veteran offensive line that returns all five starters and a dangerous receiving corps led by Jalen Nailor and Jayden Reed.

The defense will hope for improvement in their second year implementing Mel Tucker’s 4-2-5 scheme. 

We’re taking the points with Michigan State given that Northwestern is breaking in so many new starters and gets a conference game right out of the gate.

PREDICTION: Michigan State +3 (-105)

Over/Under pick

The total is low, sure, but it’s too hard to go with an Over when both teams may be breaking in a new quarterback for the first game of the season. 

We’ve already mentioned Hunter Johnson’s struggles, but quarterback play will be unknown for Michigan State as well. They’ll roll with either Temple transfer Anthony Russo or the incumbent Payton Thorne under center. The fact that they haven’t named a starter yet and it’s already game week isn’t inspiring for Over bettors.

Neither team possesses a high-flying offense. These are both hard-nosed, defensive-oriented programs. They combined to average just under 43 points a season ago, and they’ll be working out the kinks as they try to shake off the rust of a long offseason. 

Expect Northwestern to stick to their guns (the rushing attack and the defense) and for Michigan State defense to look improved in the second year of Mel Tucker’s 4-2-5 scheme.

Unders are usually the way to look at totals in Week 1 of the college football season unless you have a compelling argument for points.  We’ll take the Under.

PREDICTION: Under 45 (-110)

Michigan State vs Northwestern betting card

  • Michigan State +3 (-105)
  • Under 45 (-110)

Picks made on 09/01/2021 at 11:45 a.m. ET

NCAA parlays

Did you know that if you parlayed today’s Michigan State vs. Northwestern picks, you could win $27.27 on a $10 bet?

Use our NCAA parlay calculator to create your own parlays and see their potential payouts.

Where can I bet on college football odds?

You can bet on college football odds at every online and casino sportsbook, including NCAA moneylines, spreads, Over/Under totals, and a ton of college football prop odds. Head over to our best football betting sites for the top spots to bet on college football odds in your area.

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JD Yonke
Contributor

JD is a diehard college football fan with five years of experience writing betting and fantasy content for publications such as SportsGrid, Fantasy Points, Fantrax, and Devy Watch. An avid reader, he uses his inclination to look at things with an exhausting and in-depth, analytic viewpoint combined with a love for statistics and metrics to form a well-rounded handicapping approach.

e's an integral member of the niche (but growing!) college fantasy football community, twice traveling to Canton, OH for the Fantasy Football Expo as a member of the CFF King's Classic drafting squad. His specialization in college football DFS and prop betting taught him that there are exploitable markets to be found and that narrowing your focus is integral to being a profitable bettor.

A lifelong Californian who grew up playing baseball, basketball, football, and lacrosse, he's glad to share a passionate love for sports with this wonderful community.

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