The Ohio State Buckeyes will travel to Memorial Stadium to take on a disappointing Indiana Hoosiers team in Bloomington.
Ever since Ohio State lost to Oregon on September 11, it seems as though the Buckeyes have found their mojo again. Ohio State has knocked off opponents by massive deficits and is back in the hunt for a College Football Playoff spot.
Meanwhile, Indiana is 2-4 on the season and has been extremely poor on offense while only getting worse after quarterback Michael Penix Jr. went down with an injury.
Is it possible for Indiana to find any success offensively against Ohio State? Find out with our picks and predictions for Ohio State vs Indiana on October 23.
Ohio State vs Indiana odds
Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.
Ohio State opened as an 11-point favorite earlier this year but is now a 21-point favorite, with some books going as high as -21.5 for the Buckeyes. Meanwhile, the total has shifted from 60.5 to as low as 58.5. Make sure to shop around if you’re looking to take the Over.
Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full college football odds before placing your bets.
Ohio State vs Indiana picks
Picks made on 10/21/2021 at 8:15 p.m. ET.
Click on each pick to jump to the full analysis.
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Ohio State vs Indiana game info
• Location: Memorial Stadium, Bloomington, IN
• Date: Saturday, October 23, 2021
• Time: 7:30 p.m. ET
• TV: ABC
Ohio State vs Indiana betting preview
Weather
Be sure to monitor the gametime conditions with our NCAA football weather info.
Key injuries
Ohio State: Kamryn Babb WR (Questionable), Palaie Gaoteote IV LB (Questionable), Haskell Garrett DT (Probable), Jakailin Johnson CB (Questionable), Demario McCall WR (Questionable), Mitchell Melton LB (Questionable), Noah Potter DE (Questionable), Miyan Williams RB (Probable).
Indiana: Michael Penix Jr. QB (Out), Camron Buckley WR (Out), James Head Jr. DL (Out), Taiwan Mullen DB (Out).
Find our latest NCAA football injury reports.
Betting trend to know
Buckeyes are 7-0 ATS in their last seven games in October. Find more NCAA betting trends for Ohio State vs. Indiana.
Ohio State vs Indiana predictions
Ohio State -21 (-110)
Ohio State has won its last four games by a combined score of 218-57. That’s an average score of 54.5 to 14.25.
Its game against Oregon was a wake-up call and Ohio State instantly responded, going back to its second half against Tulsa on September 18.
Ohio State is averaging 562.7 yards per game and 48.5 points per game. This offense has been even better as of late, scoring 54.5 points in its last four games against poor opponents.
Indiana’s defense hasn’t been all that bad, but because the offense is so incompetent, the defense looks worse than it actually is. Coverage down the field has been solid for the Hoosiers, allowing just 209.3 yards per game passing.
The only problem is, if there’s one weakness on Indiana’s defense, it’s the inability to rush the passer. Therefore, Ohio State quarterback C.J. Stroud should have plenty of time in the pocket for Ohio State and make some big-time throws to the best wide receiver group in America.
Meanwhile, Indiana is riding the season out with Jack Tuttle, a junior quarterback who has three interceptions to just one passing touchdown this season. He’s completed just 51.4 percent of his passes and is really going to struggle once Ohio State’s pass rush gets to him.
Under 59.5 (-110)
At this point, I just don’t think Indiana can contribute offensively. At most, this Hoosiers team might score 14 points. But again, Indiana’s defense probably doesn't get enough credit for how well it has played.
Indiana held Michigan to 20 points and Penn State to 24 points. Those are two Top 10 teams in college football, and they were both held to a reasonable amount of points.
The ceiling for Ohio State would likely be about 45 points against Indiana and that’s if everything goes right. So, therefore, even if Indiana scores 14 and Ohio State scores 45, this game would still go under 59.5.
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