On Saturday, October 23, the Iowa State Cyclones look to deal the Oklahoma State Cowboys their first loss of the season when the two meet at Jack Trice Stadium in Ames, Iowa at 3:30 p.m. ET.
The Cowboys have won two in a row in this head-to-head series, but the Cyclones are playing some great football coming into this game. Keep reading our Oklahoma State vs. Iowa State picks and predictions to find out if the Pokes can stay perfect.
Oklahoma State vs Iowa State odds
Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.
Iowa State was a 6.5-point favorite when this game became available, but they’re now up to 7 nearly everywhere. However, they’re still hanging onto that 6.5 number at one book, which is why it’s so important to look at all of your options. Meanwhile, the total opened at 47 and is mostly between 46.5 and 47. Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full college football odds before placing your bets.
Oklahoma State vs Iowa State picks
Picks made on 10/20/2021 at 1:30 p.m. ET.
Click on each pick to jump to the full analysis.
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Oklahoma State vs Iowa State game info
• Location: Jack Trice Stadium, Ames, IA
• Date: Saturday, October 23, 2021
• Time: 3:30 p.m. ET
• TV: FOX
Oklahoma State vs Iowa State betting preview
Weather
Be sure to monitor the gametime conditions with our NCAA football weather info.
Key injuries
Oklahoma State: Trace Ford DE (Out), Jaden Bray WR (Questionable), Bryson Green WR (Questionable), Brock Martin DE (Questionable), Dezmon Jackson WR (Questionable), Langston Anderson WR (Questionable), Josh Sills OL (Questionable), Braydon Johnson WR (Out), LD Brown RB (Out)
Iowa State: Jaquan Amos DB (Questionable)
Find our latest NCAA football injury reports.
Betting trend to know
Iowa State is 7-3 in its last 10 games as a favorite. Find more NCAA betting trends for Oklahoma State vs. Iowa State.
Oklahoma State vs Iowa State predictions
Iowa State -6.5 (-122)
Oklahoma State is coming off a huge victory over Texas last week, and the Cowboys probably aren’t getting enough respect for an undefeated team at the moment. However, the Cyclones are playing some really good football over the last month of the season, and they present some real challenges for Mike Gundy’s team.
Since Matt Campbell took over as the head coach of Iowa State, the Cyclones are 8-3 SU and 10-1 ATS when playing at home in the month of October — and 18-3 ATS in October games overall in that time. They’re also 13-4 SU and 11-6 ATS when playing as a favorite of between 3.5 and 10 points in that span.
Iowa State also happens to be allowing fewer than 100 rushing yards per game this season, which is especially important when factoring in who they’re playing in this one. Cowboys running back Jaylen Warren rushed for 193 yards on 33 carries in last week’s win over Texas. Dominating on the ground like that was the reason Oklahoma State was able to win that game, but Warren is going to have a rough night against this Iowa State front. Considering quarterback Spencer Sanders isn’t anything special as a passer, that’s going to make putting up points a tough ask for this Cowboys team.
As for the Cyclones offense, things have been going much better in the passing game as of late. After a miserable start to the year, Brock Purdy has now thrown for nine touchdowns and just one interception over the last four games. He seems to have his confidence back and it’s making life on star running back Breece Hall a lot easier. Over the last four weeks, Hall is averaging 152.5 rushing yards per game. He has also scored two touchdowns in each of those four contests.
With the Cyclones finally clicking on both sides of the ball, look for them to deal the Cowboys their first loss of the season. And don’t be surprised if they do so rather comfortably.
Over 46.5 (-104)
The Over has hit in each of Iowa State’s last three games, and they now play a game with an extremely low number. While Oklahoma State could struggle to score enough points to hang around in this one, the Cowboys aren’t going to be completely blanked. They’re simply too talented for that. Meanwhile, Iowa State is averaging 42.3 points per game over the last four weeks, which shows you that this Cyclones team is capable of carrying Over bettors to the promised land.
It’s also worth noting that the Over is 8-3 when Oklahoma State is coming off a game in which the team won as a road underdog under Gundy. It’s also 9-4 when the Cowboys have faced teams that allow at most 285 yards per game in that time, showing that Gundy has generally been able to produce a solid offensive game plan against good defenses.
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