The Oklahoma Sooners are red-hot and now get a matchup with the lowly Kansas Jayhawks, certain to stay perfect in the 2021 season.
Taking an eight-game win streak in Kansas into this latest matchup, will the Sooners cover a massive spread? Keep reading our Oklahoma vs. Kansas picks and predictions to find out whether or not the Sooners will get it done.
Oklahoma vs Kansas odds
Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.
The Sooners are huge favorites in this game but apparently the number isn’t high enough. Oklahoma opened as a 38-point favorite in this one, but the number is now either 38.5 or 39. The total, meanwhile, has gone down from 67.5 to 66.5. That’s despite more of the tickets being on the Over. Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full college football odds before placing your bets.
Oklahoma vs Kansas picks
Picks made on 10/20/2021 at 6:00 p.m. ET.
Click on each pick to jump to the full analysis.
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Oklahoma vs Kansas game info
• Location: David Booth Kansas Memorial Stadium, Lawrence, KS
• Date: Saturday, October 23, 2021
• Time: 12:00 p.m. ET
• TV: ESPN
Oklahoma vs Kansas betting preview
Weather
Be sure to monitor the gametime conditions with our NCAA football weather info.
Key injuries
Oklahoma: Mario Williams WR (Questionable), Kendall Dennis DB (Questionable), Nathan Rawlins-Kibonge DE (Questionable), Cody Jackson WR (Questionable), Jeremiah Criddell S (Questionable), Isaiah Coe DL (Questionable), Delarrin Turner-Yell S (Questionable), Jalen Redmond DE (Out), Woodi Washington DB (Out), Theo Wease WR (Out).
Kansas: Kevin Terry WR (Out), Daniel HIlshaw Jr. RB (Out).
Find our latest NCAA football injury reports.
Betting trend to know
Kansas is 3-13 ATS in its last 16 home games. Find more NCAA betting trends for Oklahoma vs. Kansas.
Oklahoma vs Kansas predictions
Oklahomam -38.5 (-122)
Over the last two weeks, Oklahoma is averaging 53.5 points per game and has covered in back-to-back contests. Those performances have mostly been due to the change at quarterback, with the Sooners making Caleb Williams the team’s new starter. In a win over the Texas Longhorns two weeks ago, Williams threw for 212 yards with two touchdowns and added another 88 yards and a score on the ground. Then, Williams threw for 295 yards with four scores and no picks and rushed for 66 yards and a touchdown in a blowout win over the TCU Horned Frogs.
Williams doesn’t have as much arm talent as Spencer Rattler did, but he’s much better at executing Lincoln Riley’s offense. And his ability to run the football gives Riley the opportunity to run the show the way he did with Kyler Murray and Jalen Hurts under center. That’s bad news for a Kansas team that has allowed at least 41 points in each of the last five contests.
When these teams met last year, the Sooners won 62-9 as 38.5-point favorites. Oklahoma hasn’t lost to Kansas since the 1997 season, and the Sooners have covered in nine of the 16 games these two have played since then. There’s really just nowhere on the field where the Jayhawks have an edge, and it doesn’t help that the Sooners are playing some inspired football right now.
Don’t be surprised if this one looks a lot like it did last year, with Oklahoma winning by at least six or seven touchdowns.
Under 66.5 (-104)
Whereas last year’s blowout win by Oklahoma allowed Over bettors to cash, this one should go a bit differently. The Sooners should still put up an absurd amount of points in this one, but that number will look more like 49 or 56 or so, with the Jayhawks scoring 10 or fewer for the second year in a row.
The reason for that is that the Sooners will be running the ball a bit more in this game, and keeping the chains moving and clock rolling will make it difficult for the Over to hit in a game with such a high total. Also, as this game begins to get out of hands — which it should rather quickly — the Sooners will take their foot off the gas.
Under Riley, the Under is 5-1 in Oklahoma road games in which the total is between 63.5 and 70 points. The Under is also 6-1 when Oklahoma is coming off three consecutive Overs under Riley.
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