To say that 2021 has been a disappointment for the Washington Huskies might be an understatement. For a program that hasn’t had a losing season since 2009, a 2-4 start is not up to par with expectations.
Meanwhile in Tucson, the Jeff Fisch era has gotten off to an uninspiring 0-6 start. Will the Wildcats be able to end their 18-game losing streak this Friday, or will the Huskies get back on track and notch a much-needed PAC-12 win?
Check out our picks and predictions for the Washington Huskies vs. the Arizona Wildcats on Friday, October 22 to find out.
Washington vs Arizona odds
Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.
Washington opened as -15.5 favorites. The line has moved to -17.5 across most books at the time of this writing. Be sure to check out the full college football odds before placing your bets, and also view the full line movement for this game.
Washington vs Arizona picks
Picks made on 10/19/2021 at 11:00 p.m. ET.
Click on each pick to jump to the full analysis.
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Washington vs Arizona game info
• Location: Arizona Stadium, Tucson, AZ
• Date: Friday, October 22, 2021
• Time: 10:30 p.m. ET
• TV: ESPN2
Washington vs Arizona betting preview
Weather
Be sure to monitor the gametime conditions with our NCAA football weather info.
Key injuries
Washington: Kyle Phillips WR (Questionable), Ja’Lynn Polk WR (Questionable), Alphonzo Tuputala LB (Questionable)
Arizona: Gunner Cruz QB (Out), Jordan McCloud QB (Out), Josh Donovan OL (Questionable), Kyon Barrs DL, JB Brown DL, Treshaun Hayward LB
Find our latest NCAA football injury reports.
Betting trend to know
The Huskies are 5-1 ATS in the last six meetings between these two schools. Find more NCAA betting trends for Washington vs. Arizona.
Washington vs Arizona predictions
Washington -17.5 (-110)
Let’s get this out of the way — both teams have struggled out of the gate in 2021. The Huskies sit at 2-4 while going only 1-5 ATS, and the Wildcats are 0-6 with a 2-4 ATS record.
Although things are trending downward in Washington, they’re currently even worse in Arizona. The Wildcats have lost 18 straight games and haven’t won a contest since October 5, 2019, against Colorado. Kevin Sumlin left this program in a world of hurt, and first-year coach Jeff Fisch has a long rebuild in front of him. This is going to take a few years to fix.
One thing that we know for certain about Washington is that the pass defense is still elite. Led by star cornerback Trent McDuffie, the Huskies have held opposing offenses to only 153 passing yards per game — the fourth best mark in the country.
With quarterbacks Jordan McCloud and Gunner Cruz lost for the season due to injury, this Arizona offense is in a dark place. Last week’s loss to Colorado was the program’s first shutout loss in nine years. Success will be hard to come by through the air.
The Huskies are glad to welcome back star linebacker Zion Tupuola-Fetui (seven sacks in three games a year ago) only six months after he tore his Achilles tendon. ZTF returned against UCLA a week ago and had three hurries in limited playing time.
The Wildcats have been brutal following a straight up loss, going 2-14 ATS in the last 16 such games. They’ve been a money burner in conference play with a 1-6 ATS mark in their last seven PAC-12 matchups.
The Huskies haven’t had a losing season since 2009. While they’ve taken a visible step back under coach Jimmy Lake, this is still a program of a much higher caliber than Arizona.
In a matchup between two underwhelming teams, it’s clear which team is struggling more. The Wildcats are fresh off a 34-0 loss to a Colorado team that had yet to find a win over an FBS school. We’ll take the Huskies.
Over 45.5 (-110)
Plug your nose on this one, but this total is simply too low to consider an Under play.
This Arizona defense has been dreadful, allowing no less than 34 points to each of the last 4 FBS teams that they have played. Last week they played a Colorado team that had scored multiple touchdowns in a game only once on the season, and yet still managed to allow 34 points in a humiliating loss.
This Huskies team is typically effective at running the football but is averaging only 115.2 yards per game on the season. This could be a get-right spot for their offense against a Wildcats defense allowing a whopping 202.2 rushing yards per game (112th in the country).
The Huskies have shown previously that they can take advantage against an overmatched defense, racking up 52 points in a Week 3 demolition of Arkansas State. This Wildcats defense may not be on the level of Arkansas State, but they aren’t far off.
Arizona could be able to contribute a few points to this total against a poor Washington rushing defense surrendering 190.7 yards per contest (104th).
The Over has found a way to hit when these two teams play, going 9-3 in the last 12 meetings.
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