College Football Parlay Picks for Week 6: Michigan's Defense Stays Stingy

We’re nearing the mid-point of college football’s regular season as Week 6 action gets underway. Yet even with several games under our belts, there still seem to be some teams that aren’t being properly evaluated by oddsmakers. 

The Colorado Buffaloes have lost two in a row, but Deion Sanders has transformed the program into one deserving of respect. I’ve been low on the Iowa Hawkeyes all year long, but the college football odds may be overreacting to their lopsided loss to the Penn State Nittany Lions two weeks ago. I’m also looking at the incredible Michigan Wolverines defense as the basis for a same-game parlay this weekend.

Read on to learn which parlays I’m going to play on Saturday in my free college football picks for Week 6. 

Week 6 college football parlay picks

• Iowa -2.5 + Colorado -4 (+264)
• Michigan -18 + u45.5 + Minnesota team total u13.5 (+300)

Click on each pick to jump to the full analysis.

Best college football parlay Week 6

Iowa -2.5

Colorado -4

+264 at Caesars

Iowa was never as good as the polls suggested when the Hawkeyes were an early-season mainstay in the Top 25. But neither are they are bad as people seem to think they are since their 31-0 drubbing at the hands of Penn State a couple weeks ago. Iowa bounced back with a 10-point win over Michigan State, and now gets a fairly comfortable home game against the Purdue Boilermakers on Saturday.

Purdue is just 2-3, having lost by two scores or more to both the Syracuse Orange and the Wisconsin Badgers at home in recent weeks. Iowa may not be able to get much done on the offensive end behind Cade McNamara, but its defense has allowed just 16.8 points per game. I’m comfortable taking the Hawkeyes to win at home and covering the spread of less than a field goal.

Another team that has seen its stock plummet is Colorado. After being the darlings of college football, consecutive losses to the Oregon Ducks and the USC Trojans have left many people feeling as though the Buffaloes aren’t for real, at least not yet. But Colorado showed a lot of heart and offensive firepower in the second half of the USC game, with Shedeur Sanders throwing four touchdowns and running for another against one of the best teams in college football.

This week, Colorado gets a huge step down in competition against the 1-4 Arizona State Sun Devils. Arizona State hasn’t beaten an FBS team yet this year, and is only averaging just 17.6 points per game on offense. There’s no way the Sun Devils can keep up with Colorado in what will inevitably be a shootout, so I’m taking the Buffaloes as the second half of my parlay with Iowa.

Best college football SGP Week 6

Michigan -18
Under 45.5
Minnesota TT Under 13.5

+300 at DraftKings

We’ve seen some excellent defenses over the years in college football, but it’s beginning to look like this Michigan defensive unit might be truly special. In five games, it has allowed an average of just six points per game. No team has managed to score more than seven points against the Wolverines, and they’ve won every game by at least 25 points. 

The fact that Michigan is winning isn’t a surprise after they made the 2022 College Football Playoff, but most teams were at least able to get into double digits against the Wolverines last year. The Minnesota Golden Gophers are now going to try to become the first team to accomplish that feat this season on Saturday.

It’s hard to imagine Michigan will have much trouble against the 3-2 Gophers, who have already lost to the Northwestern Wildcats and only beat the Louisiana-Lafayette Ragin’ Cajuns 35-24 last weekend. I fully expect the Wolverines to continue their streak of lopsided victories, as this doesn’t represent a huge step up in competition for them.

Along with taking Michigan to cover the spread, I also think they’ll hold Minnesota Under their team total of 13.5 points. The Golden Gophers are only averaging 24 points per game against the pedestrian defenses they’ve played so far this year. Getting in the endzone twice against the Wolverines would be a huge accomplishment, and not one I think they’re up to, as two teams have already held Minnesota under that number already this season.

Finally, I’m predicting the game total to stay Under 45.5 points. While Michigan flashed some offensive might against a poor Nebraska team, it has otherwise played in the 30s in every game this year. If that’s the case again, and Minnesota doesn’t contribute much to the scoreboard, I expect these teams to stay below the number on Saturday.

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