Colts vs Raiders Week 10 Picks and Predictions: Defenses Will Dominate in the Desert

After two terrible performances in Week 9, Indianapolis and Las Vegas will look to salvage their seasons with a win at Allegiant Stadium on Sunday. Find out where the betting edge lies in our Colts vs. Raiders betting picks.

Trevor Knapp - Publishing Editor at Covers.com
Trevor Knapp • Publishing Editor
Nov 13, 2022 • 08:23 ET • 4 min read
Derek Carr Las Vegas Raiders NFL
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The Indianapolis Colts are coming off an embarrassing 26-3 loss to the Patriots last weekend, while the Las Vegas Raiders blew a 17-0 lead to the Jaguars. Both teams come into this Week 10 tilt with losing records and will look to turn their season around at Allegiant Stadium on Sunday? 

Can a new head coach inject life into the Colts, or will the Raiders get a big home win? Find out in our free NFL picks and predictions for Colts vs. Raiders on November 13. 

Colts vs Raiders best odds

Colts vs Raiders picks and predictions

The Indianapolis Colts were the story of the league this week... for all the wrong reasons. After firing head coach Frank Reich, owner Jim Irsay went on to name former Pro Bowl center Jeff Saturday as interim HC in one of the most shocking recent hires. 

While Saturday has been a part of winning football in Indy, his only head coaching experience comes from the high school level. The former ESPN analyst is now thrust into coaching a team that has lost three in a row in a row and is starting a rookie in Sam Ehlinger, who's entering just his third start. 

The Colts managed just eight first downs last week against the Patriots and gave up a whopping nine sacks. While having the highest-paid O-line in the NFL, it is unironically the Colts' weakest unit. Although Jonathan Taylor is expected to return on Sunday, last year's rushing leader is averaging just 4.3 yards per carry and has reached the end zone just once this season.

It hasn't been any better of a campaign for the Las Vegas Raiders. After coughing up a three-possession lead against Jacksonville, Las Vegas is now 2-6 on the season under first-year head coach Josh McDaniels. 

The Raiders were expected to be a playoff threat with the addition of star receiver Davante Adams in free agency, but it's been a complete circus. Quarterback Derek Carr hasn't developed much chemistry with Adams, tight end Darren Waller has been banged up all season long, and slot-man Hunter Renfrow has been a complete non-factor. Both Waller and Renfrow will be sidelined due to injury on Sunday.

Carr is in the midst of his worst statistical season since 2017. Carr holds a 88.5 QB rating coming into Week 10 and has a TD/INT ratio of 11/5. Even more startling are his dismal fourth quarter numbers. 

The Colts defense will be able to load the box on Jacobs and force Carr to beat them over the top. Meanwhile, the Raiders should feast on the Colts' weak O-line, with pass rushers Maxx Crosby and Chandler Jones wreaking havoc all game long. 

My best bet: Under 41 (-110 at bet365)

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Colts vs Raiders spread analysis

The Raiders opened as 4.5-point favorites, and it has stayed that way despite notable injuries to Waller and Renfrow. They also released safety Johnathan Abram earlier this week, marking yet another first-round selection by Las Vegas that has gone to complete waste. 

If anything, the Raiders remaining at -4.5 says all you need to know about the state of the Colts. A head coaching switch-up midseason for a guy that hasn't been in the locker room until earlier this week, as well as Ehlinger playing with little experience behind the worst O-line in football don't mix for a good result. 

I don't have a strong lean on the spread, but you may as well be throwing money away if you're betting on the Colts at this point. If you want to pick a side, go with the Raiders. 

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Colts vs Raiders Over/Under analysis

The Colts are 1-8 to the Under this season, while the Raiders are at 4-4. Although linebacker Shaquille Leonard finds himself back on the IR, Indy remains a formidable defensive group and should make bettors feel comfortable about backing a low-scoring affair.

Gus Bradley's unit is most capable upfront, boasted by All-Pro defensive tackle DeForest Buckner, Grover Stewart, as well as second-year defensive end Kwity Paye. Bradley was also the defensive coordinator for the Raiders last season, so he should be able to somewhat exploit Carr's weaknesses on Sunday.

Mix in the Colts' notorious slow starts to games and Carr's tendency to fall apart in the fourth quarter? I love taking the Under in this spot. 

Colts vs Raiders betting trend to know

The road team is 4-0 ATS in their last four meetings. Find more NFL betting trends for Colts vs. Raiders.

Colts vs Raiders game info

Location: Allegiant Stadium, Las Vegas, NV
Date: Sunday, November 13, 2022
Kickoff: 4:05 p.m. ET
TV: CBS
Opening odds: Raiders -4.5, 42.5 O/U

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Trevor Knapp - Covers
Publishing Editor

Trevor joined the Covers content team as a publishing editor in early 2022. Growing up in Vancouver, he studied Broadcast and Online Journalism at the British Columbia Institute of Technology (BCIT), and interned with TSN and Sportsnet Radio while also writing for the Daily Hive.

An avid bettor of the MLB, NFL, and CFL, Trevor advises his fellow sports bettors to leave their hearts at the door and not hesitate to fade their favorite team. It's a strategy he follows regularly as an apathetic Toronto Blue Jays and Indianapolis Colts fan.

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