Los Angeles @ San Francisco preview

Last Meeting ( Dec 31, 2017 ) San Francisco 34, L.A. Rams 13

The undefeated Los Angeles Rams have run roughshod over the league in 2018 while the San Francisco 49ers have endured plenty of significant injuries starting as early as the preseason. The 49ers, however, have one positive to take into Sunday's matchup at Levi's Stadium: They have won four of the last five meetings between the NFC West rivals.

Todd Gurley hasn't been shy about gouging the 49ers -- and the rest of the league, for that matter -- as he collected three touchdowns (two rushing, one receiving) in last year's series and is coming off a career-high 208 yards and two scores in Sunday's 23-20 win over Denver to earn NFC Offensive Player of the Week honors. "He's been running wild ever since I got to this team," Rams wideout Robert Woods said. "It's just a credit to this line, this game plan, and his work ethic. And he's a beast. ... He's pretty much unstoppable right now." San Francisco went to great lengths to stop itself en route to losing its fourth straight game on Monday. C.J. Beathard, who has stepped in for the injured Jimmy Garoppolo, showed flashes of promise but a late interception led to his undoing in a 33-30 setback versus Green Bay.

TV: 4:25 p.m. ET, CBS. LINE: Rams -9.5. O/U: 52

ABOUT THE RAMS (6-0): Gurley's 208 rushing yards trumped the passing total of quarterback Jared Goff (201), who was hindered by the loss of one of his prized targets. Cooper Kupp is expected to be sidelined several weeks with a sprained knee, although fellow wideouts Brandin Cooks and Woods are more than capable of carrying the load. Cooks has 23 receptions, 418 yards and a touchdown in a four-game stretch while Woods has 406 yards and three scores in that span. On the other side of the ball, Aaron Donald has four sacks in his last three games and fellow defensive tackle Ndamukong Suh has three in his last four.

ABOUT THE 49ERS (1-5): With running back Jerick McKinnon and Garoppolo sidelined by season-ending injuries, the 49ers received a jolt with the return of Marquise Goodwin to the lineup on Monday. The 27-year-old Goodwin showed no signs of the quadriceps injury that shelved him early in the season opener at Minnesota by recording career highs in receiving yards (126) and touchdowns (two). "Guys are respecting (Goodwin's) speed," Beathard said. "You've got to respect his speed. He can take the tops off of coverages, so it definitely helps having him out there." Running back Matt Breida stands to benefit from that as he bids for his third straight game with a touchdown and fourth in a row at home.

EXTRA POINTS

1. San Francisco TE George Kittle recorded 100 receiving yards in his last encounter with Los Angeles.

2. The Rams lead the NFL in total yards (2,786), yards per game (464.3) and rushing yards per contest (154.3).

3. 49ers WR Pierre Garcon, who had a team-best 142 yards receiving in his last meeting with Los Angeles, has surpassed 50 yards just twice in six games this season.

PREDICTION: Rams 38, 49ers 17