San Francisco @ Arizona preview

Last Meeting ( Oct 7, 2018 ) Arizona 28, San Francisco 18

The San Francisco 49ers have lost all four of their road games this season and the Arizona Cardinals have dropped each of their four contests at home en route to sharing the basement in the NFC West. One team is likely to finally get in the win column on Sunday, and the 49ers will have revenge on their minds when they visit the Cardinals, who have won the last seven meetings.

San Francisco is looking to snap a five-game losing streak that includes a 28-18 setback against Arizona at home in Week 5. The 49ers, who were trounced 39-10 by the Los Angeles Rams last week, are getting closer to notching their first road win as their last two losses away from home were by a total of five points. Arizona had lost a pair of home contests by a total of five points before getting pounded 45-10 by Denver last week. The Cardinals, who are last in the NFL in total yards (220.7) and rushing yards (64.6), addressed the problem by replacing offensive coordinator Mike McCoy with Byron Leftwich following the loss to the Broncos.

TV: 4:25 p.m. ET, FOX. LINE: 49ers -1. O/U: 42.5

ABOUT THE 49ERS (1-6): C.J. Beathard passed for a career-high 349 yards and two touchdowns in the Week 5 showdown but also threw a pair of interceptions. The 24-year-old has run for a score in each of the last two contests against the Cardinals while running back Matt Brieda caught a TD pass in the Week 5 defeat. Brieda leads the NFL with an average of 6.54 yards per rush while George Kittle tops all tight ends in the league with 367 yards after the catch.

ABOUT THE CARDINALS (1-6): Larry Fitzgerald is hoping the change at offensive coordinator benefits him, as he has made only 26 catches for 255 yards through seven games. The 35-year-old needs 135 receiving yards to pass Hall-of-Famer Terrell Owens (15,934) for second place on the all-time list. David Johnson has been an offensive force against San Francisco of late, rushing for six scores and adding a TD reception in the last four meetings.

EXTRA POINTS

1. Kittle leads the 49ers in both receptions (32) and receiving yards (527).

2. Arizona signed S Eddie Pleasant and OL Oday Aboushi while releasing CB Deatrick Nichols and DT Ifeadi Odenigbo.

3. San Francisco signed QB Tom Savage and placed DB Adrian Colbert (ankle) on injured reserve.

PREDICTION: Cardinals 23, 49ers 21