Arizona @ San Francisco preview

Last Meeting ( Nov 5, 2017 ) Arizona 20, San Francisco 10

The Arizona Cardinals have a solid chance to register their first victory of the season when they visit the injury-riddled San Francisco 49ers on Sunday. Arizona, which has lost its last two games by a total of five points after being outscored 58-6 in its first two contests, has won six consecutive meetings with San Francisco.

Rookie quarterback Josh Rosen made his first career start in last week's 20-17 setback against Seattle and completed 15-of-27 passes for 180 yards and a touchdown as the Cardinals fell to 0-4 for the first time since 1986 while in St Louis. The 49ers hope to keep Arizona winless but will have to do so with an offense that has been ravaged by injuries. Wide receiver Dante Pettis and tackle Joe Staley suffered knee injuries in last week's 29-27 loss to the Los Angeles Chargers and have not practiced this week while center Weston Richburg and tackle Mike McGlinchey have been limited participants, also due to knee ailments. C.J. Beathard threw for a career-high 298 yards and two touchdowns with a pair of interceptions in his first start since Jimmy Garoppolo went down with a season-ending knee injury.

TV: 4:25 p.m. ET, FOX. LINE: 49ers -4. O/U: 40

ABOUT THE CARDINALS (0-4): The Sam Bradford experiment could be over as the veteran quarterback was inactive against the Seahawks after starting each of Arizona's first three games this season. The 30-year-old, who is with his fourth team since being drafted first overall by the then-St. Louis Rams in 2010, has completed 50-of-80 passes for 400 yards with two touchdowns and four interceptions this year. Running back David Johnson had his most productive game of the campaign last week as he rushed for 71 yards and a TD while gaining another 41 on three receptions.

ABOUT THE 49ERS (1-3): With San Francisco's offensive line losing members to injuries, Matt Breida gained only 39 yards on nine carries in the loss to the Chargers. The 23-year-old, who ranks third in the NFL with 313 rushing yards, has been limited in practice this week due to a shoulder injury. The 49ers could be without another wide receiver on Sunday as Marquise Goodwin, who is battling hamstring and quadriceps injuries that caused him to miss a portion of last week's contest, was a limited participant in Thursday's practice after sitting out the previous day.

EXTRA POINTS

1. Johnson has scored seven touchdowns (one receiving) in his last six road games against NFC West rivals.

2. San Francisco's George Kittle leads all NFL tight ends with 218 yards after catches this season.

3. Arizona WR Larry Fitzgerald (hamstring/back), who was limited in Thursday's practice, has recorded 2,169 yards and 17 touchdowns against San Francisco - his highest totals versus any opponent.

PREDICTION: 49ers 24, Cardinals 20