The Seattle Seahawks look to begin their season 6-0 as they face the Arizona Cardinals in NFL action in Week 7. The Cardinals are 4-2 and coming off a 38-10 rout of the Dallas Cowboys on Monday Night Football but NFL betting odds have them installed as 3.5-point home underdogs for Sunday night, as this game was flexed on Friday from a 4:05 p.m. ET kickoff to the primetime spot.
We break down the NFL odds with our free Seahawks vs. Cardinals picks and predictions for Sunday, October 25, on Sunday Night Football.
Seattle Seahawks vs Arizona Cardinals betting preview
Weather
It's expected to be a warm and clear evening at State Farm Stadium in Glendale, Arizona, with temperatures around 76 degrees at kickoff and a mild breeze of 8 mph. Be sure to monitor the gametime conditions with our NFL weather info.
Key Injuries
Seahawks: Lano Hill S (Out), Jamal Adams S (Out), Mike Iupati G (Out), Bruce Irvin LB (Out).
Cardinals: JR Sweezey G (Out), Chandler Jones LB (Out), Maxx Williams TE (Out), Robert Alford CB (Out), Marcus Gilbert OT (Out).
Find our latest NFL injury reports.
Betting trend to know
The Seahawks are 7-1 ATS in their last eight road games against a team with a winning home record. Find more NFL betting trends for Seahawks vs. Cardinals.
Against the spread (ATS) pick
The Seahawks have started the year a perfect 5-0, which is pretty surprising for a team that ranks dead-last in the NFL in total defense by surrendering 471.2 yards per game. That said, they lead the league in takeaways, which helps them rank a more respectable 18th in the league in scoring defense.
More importantly, the Seahawks high-powered offense has simply allowed them to outpace their opposition. Led by MVP front-runner Russell Wilson, who has completed 72.8 percent of his passes for 1,502 yards and 19 touchdowns through five games, Seattle is leading the league in yards per play and scoring (33.8 points per game).
The Cardinals have yet to face an offense as dynamic as the Seahawks this season (and no the Andy Dalton-led Cowboys don't count) but the real reason I'm fading them is the tough spot they are in: Arizona is on a short week, following a big performance on Monday night and could be due for a letdown against a Seahawks squad coming off a bye.
Another factor to keep in mind is that despite all the chatter about the Seahawks home-field advantage at CenturyLink Field, they travel very well. Seattle is 13-4-1 ATS in its last 18 road games.
PREDICTION: Seattle -3.5 (-110)
Over/Under pick
Both squads rank among the Top-8 teams in the league in yards per game but there's reason to suspect this one might sneak under the high total of 56.
The Cardinals offense has been spearheaded by a ground game that piles up 161 rushing yards per game and 5.3 yards per carry. Seattle's offense, on the other hand, has been led by Wilson and an aerial attack that piles up 280.4 passing yards per game.
But it just so happens that the strengths of both offenses align with the strengths of each team's stop units. The Seahawks secondary has been vulnerable but they allow just 100.8 rushing yards per game and 3.9 yards per carry, both good for seventh-best in the league.
Arizona limited Wilson to a combined total of 409 passing yards in two meetings last year and have shown improvement on the back end this season, allowing just 6.1 yards per pass attempt. With the Cardinals 6-0 to the Under this year back it again on Sunday.
PREDICTION: Under 56 (-110)
Player Prop
From Mike Mamula to Vernon Ghoulston the NFL has a long list of workout warriors who blew up at the NFL Draft combine before struggling to actually perform in pads. Seahawks receiver DK Metcalf is not one of those guys.
After the shredded wideout weighed a shredded 228 pounds and ran a blazing 4.33 40-yard dash at the combine last year, there was talk he could end up being drafted in the Top 15. Instead he fell to the bottom of the second round where Seattle gobbled him up.
Metcalf has been an absolute gift for Wilson turning into one of the best receivers in the league during his sophomore year. He's also been a model of consistency, racking up more than 90 receiving yards in each of his first five games of the year. With the Over/Under on his receiving yards set at just 68.5, hammer the Over.
PREDICTION: DK Metcalf receiving yards Over 68.5 (-112)
Seahawks vs Cardinals betting card
- Seattle -3.5 (-110)
- Under 56 (-110)
- DK Metcalf receiving yards Over 68.5 (-112)
Did you know that if you parlayed this week’s NFL Seahawks vs. Cardinals picks, you could win $58.99 on a $10 bet?
Use our NFL parlay calculator to create your own parlays and see their potential payouts.
Where can I bet on the NFL?
You can bet on NFL odds at every online and casino sportsbooks, including NFL moneylines, spreads, Over/Under totals and a ton of NFL prop odds. Head over to our best-suggested sportsbooks for the top spots to bet on NFL odds in your area.