Clemson vs NC State Picks and Predictions: Tigers on the Prowl Again

The Tigers have been getting de-clawed so far this season, and are looking to bounce back against another ACC apex predator. Find out why we think they'll re-assert themselves with our Clemson vs NC State picks.

Douglas Farmer - Betting Analyst at Covers
Douglas Farmer • Betting Analyst
Sep 24, 2021 • 15:25 ET • 2 min read
D.J. Uiagalelei Clemson Tigers college football
Photo By - USA TODAY Sports

The Tigers emboldened doubters last weekend. Will silencing those critics come at the Wolfpack’s expense?

Clemson’s 14-8 near-miss against lowly Georgia Tech a week ago opened the door for wonders if the Tigers might finally lose their grip on the ACC. If anyone is primed to rip the ACC Atlantic division away from Clemson, it should be the preseason darling Wolfpack.

Here are our free college football picks and predictions for Clemson at North Carolina State on Saturday, September 25, with kickoff set for 3:30 ET.

Clemson vs NC State odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

The Tigers began the week as 12.5-point favorites, an odd number and one that was quickly dropped to 10 points. Occasionally, Wolfpack money would drop it another half point, but it has settled firmly at 10 as the weekend begins.

The total began the week at 47 or 47.5, depending on the book, and after spiking to 48 or 48.5 during the week, it has returned to 47.5.

Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full college football odds before placing your bets.

Clemson vs NC State picks

Picks made on 9/24/2021 at 2:45 p.m. ET.
Click on each pick to jump to the full analysis.

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Clemson vs NC State game info

Location: Carter-Finley Stadium, Raleigh, NC
Date: Saturday, September 25, 2021
Time: 3:30 p.m. ET
TV: ESPN

Clemson vs NC State betting preview

Weather

Be sure to monitor the gametime conditions with our NCAA football weather info.

Key injuries

Clemson: Baylon Spector LB (Questionable), Mason Trotter OL (Questionable), Jake Venables LB (Questionable), Tyler Davis DT (Out), Fred Davis CB (Out), Tayquon Johnson OG (Out), Dietrick Pennington OL (Out)
NC State: Payton Wilson LB (Out)
Find our latest NCAA football injury reports.

Betting trend to know

Even with last year’s strong offense led by Trevor Lawrence and Travis Etienne accounting for half these games, the Under has hit in five of Clemson’s last six games, including all three this season. It has also hit in six of North Carolina State’s last eight games, including two of three this season. Find more NCAA betting trends for Clemson vs. NC State.

Clemson vs NC State predictions

Tigers head coach Dabo Swinney said Georgia Tech lined up with “absolutely nothing that we prepared for” after last week’s lightning-paused close call. That may have been the rare head coach covering for his players after a tight game.

By no means did Clemson play well, but the oddity of a game delayed for hours by lightning may have impacted an offense already struggling to find its rhythm. In other words, the Tigers are not as bad as their most recent game.

They still held Georgia Tech to 298 total yards and 3 of 14 on third down, and offensively, Clemson may be on the verge of uncovering a new star in freshman running back Will Shipley, who took 21 carries for 88 yards and two scores last week.

The defense has never been the Tigers’ problem as long as they’re not facing Ohio State. That should keep North Carolina State in check just enough for Shipley to cover a spread seemingly knocked down by that most recent impression.

The Wolfpack has totaled 17 points in its last two games against Clemson. Given the Tigers defense is not yet a weakness, and given that it knows it needs to protect an offense still finding itself, North Carolina State should struggle to score again.

With Clemson defensive coordinator Brett Venables dialed in, the Wolfpack may not top 17 points, and asking this Tigers offense to cruise past 30 feels ambitious when it managed just 49 against FCS-level South Carolina State.

NCAA parlays

Did you know that if you parlayed our Clemson vs. NC State picks, you could win $26.45 on a $10 bet?

Use our college football parlay calculator to create your own parlays and see their potential payouts.

Where can I bet on college football odds?

You can bet on college football odds at every online and casino sportsbook, including NCAA moneylines, spreads, Over/Under totals, and a ton of college football prop odds. Head over to our best football betting sites for the top spots to bet on college football odds in your area.

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Douglas Farmer
Betting Analyst

Douglas Farmer spends his days thinking about college football and his nights thinking about the NBA. His betting habits and coverage follow that same pattern. He covered Notre Dame football for various outlets from 2008 to 2024, most notably spending eight seasons as NBC Sports’ beat writer on the Irish. That was also when his gambling focus took off. Knowing there were veteran beat writers with three decades more experience than he had, Douglas found his niche by best recognizing Notre Dame’s standing in each year’s national landscape, a complex tapestry most easily understood and remembered via betting odds.

In 2021, that interest created a freelance opportunity with Covers, a role that eventually led to Douglas joining the company full-time in 2023. In the fall, Douglas will place five or six dozen bets each week, a disproportionate amount via BetRivers because the operator tends to have lines slightly different than the rest of the market. The same can be said of Circa Sports’ futures markets.

While Douglas is an avid NBA fan and covers the league throughout the year, the vast majority of his bets are on college football, because that is the biggest key to sports betting: Know what you do not know.

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