Indianapolis @ Philadelphia preview

Last Meeting ( Aug 27, 2016 ) Philadelphia 33, Indianapolis 23

The City of Brotherly Love is set to welcome back Carson Wentz with open arms as the franchise quarterback returns to lead the Philadelphia Eagles against Frank Reich and the visiting Indianapolis Colts on Sunday. Wentz watched as Nick Foles led the Eagles to the franchise's first Super Bowl title as well as a 1-1 mark this season while recovering from an ACL and LCL tear sustained in December.

"We expect to go out and start fast, play fast, be clicking, and so I truly believe that's a realistic expectation," said Wentz, who is setting the bar high after the team was limited to just 39 points in its first two games. While Wentz returns, the Eagles have several other question marks on offense with injuries to Jay Ajayi (back) and tackle Jason Peters (quad) as well as a banged-up wide receiver corps. While Philadelphia is coming off a 27-21 setback to Tampa Bay, Indianapolis presented new head coach -- and former Eagles offensive coordinator -- Reich with his first win following Sunday's 21-9 triumph over Washington. Andrew Luck tossed a pair of touchdown passes for the second straight game and aims to exploit the Eagles' 28th-ranked pass defense that was shredded by Buccaneers quarterback Ryan Fitzpatrick.

TV: 1 p.m. ET, FOX. LINE: Eagles -6.5. O/U: 47.5

ABOUT THE COLTS (1-1): Four-time Pro Bowl wide receiver T.Y. Hilton recorded a touchdown pass in his first two games this season before providing even more good news to the fanbase on Thursday by downplaying the severity of a quad injury that has forced him to miss two days of practice: "I'm feeling good. I'm still getting there. I should be fine. Nothing to worry about," Hilton said on NFL Network. While Hilton hasn't missed a game since the 2014 season and believes he'll be set to suit up for Week 3, running back Marlon Mack may not be as fortunate as he nurses both a foot and hamstring injury. Jordan Wilkins had 61 yards rushing against the Redskins while fellow rookie Nyheim Hines celebrated his first career rushing touchdown, but the two will face the league's top-ranked rush defense (58.5 yards per game).

ABOUT THE EAGLES (1-1): Ajayi shares the NFL lead with three rushing touchdowns this season, although he was limited to just seven carries for 23 yards and a score against the Buccaneers on Sunday. With Ajayi and Darren Sproles (hamstring) nursing their respective injuries, Corey Clement could see an advanced workload out of the backfield against the Colts with Wendell Smallwood contributing as well. Nelson Agholor, who has reeled in eight receptions in both games this season, leads a depleted group of wide receivers that was bolstered by the return of Jordan Matthews this week. Matthews was summoned after Mike Wallace was placed on injured reserve for the Eagles, who anxiously are awaiting the return of Alshon Jeffery (shoulder).

EXTRA POINTS

1. Indianapolis rookie LB Darius Leonard earned AFC Defensive Player of the Week honors after collecting 18 tackles, a sack and a forced fumble on Sunday.

2. Philadelphia LB Jordan Hicks has a team-leading 16 tackles and 1.5 sacks this season.

3. Like Hilton, Colts TE Eric Ebron has a touchdown reception in both games of 2018.

PREDICTION: Eagles 21, Colts 17