Detroit @ San Francisco preview

Last Meeting ( Dec 27, 2015 ) San Francisco 17, Detroit 32

Matt Patricia's debut as coach of the Detroit Lions was a complete disaster, but his club looks to put the beating aside when it visits the San Francisco 49ers on Sunday. Detroit was walloped 48-17 by the New York Jets in a dismal performance on Monday Night Football in which Matt Stafford was intercepted four times.

Patricia, who formerly was the defensive coordinator of New England, told his new team that it has to immediately forget about the season-opening drubbing. "Every week is different and every week you have to start over," Patricia told reporters. "You can't let one week bleed into another week. You have to learn and, unfortunately on a very short week, you have to learn quickly. We have to refocus our energy and get ready for the 49ers." San Francisco is optimistic that it is ready to challenge for a postseason berth, but the club looked spotty in a 24-16 loss to Minnesota. Jimmy Garoppolo threw three interceptions, one of which was returned for a touchdown by Mike Hughes.

TV: 4:05 p.m. ET, FOX. LINE: 49ers -6. O/U: 48

ABOUT THE LIONS (0-1): Stafford passed for 301 yards and two touchdowns while also getting his knee banged up, and he was hot happy with the outcome. "We don't ever want to go out there and play poor football," Stafford told reporters. "We're disappointed and frustrated with our own performance. We want to be better than that - and we are better than that - but we have to go out there and play better." Cornerback Quandre Diggs had a 37-yard interception return for touchdown on Detroit's first defensive snap, but the unit's breakdowns included allowing New York's Isaiah Crowell to rush 62 yards for a score.

ABOUT THE 49ERS (0-1): Garoppolo passed for 261 yards and one touchdown, prompting coach Kyle Shanahan to say that his signal-caller is bouncing back quickly from a mental standpoint. "I'd be disappointed if it was different," Shanahan told reporters. "Jimmy tries his hardest every week. I know he didn't have his best game last week, but he doesn't need to come in here and make stuff up. He's had some successful games in this league. He's going to have plenty more. He just needs to get back to work." Defensive end DeForest Buckner was sharp in the season opener, recording a career-best 2 1/2 sacks, and rookie linebacker Fred Warner registered 12 tackles and a forced fumble in his NFL debut.

EXTRA POINTS

1. The 49ers have won nine of the last 10 meetings.

2. Detroit WR Kenny Golladay made seven catches for 114 yards against the Jets for his first career 100-yard game.

3. San Francisco placed LB Brock Coyle (concussion/back) on injured reserve and will decide later whether or not he will return this season.

PREDICTION: 49ers 27, Lions 17