The Giants had their way with the Oakland Athletics last night at Oracle Park, sounding defeating them 8-2. San Francisco is now won five straight, while the Athletics sit at the .500 mark 18 games into the young season.
In game two of the crosstown rivalry, will the A's get back in the win column or can the Giants continue their impressive win streak?
Find out in our free MLB picks and predictions for Athletics vs. Giants on Wednesday, April 27.
Athletics vs Giants odds
This odds widget represents the best odds available for each betting market from regulated sportsbooks.
The line opened with the Giants as -145 favorites, with the total set at 7.5, slightly juiced to the Under at -115. Money has since poured in on San Francisco, making the Giants -170 on the moneyline. The total has also dropped half a point to 7.0. The Over/Under for yesterday's game between the A's and Giants was 6.5, and the game went Over.
Use the live odds widget above to track any future line movements right up until first pitch and be sure to check out the full MLB odds before placing your bets.
Athletics vs Giants predictions
Picks made on 4/27/2022 at 1:00 p.m. ET.
Click on each pick to jump to the full analysis.
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Athletics vs Giants game info
• Location: Oracle Park, San Francisco, CA
• Date: Wednesday, April 27, 2022
• First pitch: 9:45 p.m. ET
• TV: NBCS-CA, NBCS-BAY
Athletics vs Giants betting preview
Starting pitchers
Paul Blackburn (2-0, 1.80 ERA): Blackburn has made three starts this season, with Oakland getting the win in all of them. In his last start on April 21, he went five innings, allowing just three hits and one earned run to the Orioles. The 28-year-old right-hander has been with the A's since 2017 and has a career ERA of 5.35 in 153 innings pitched.
Sam Long (0-0, 0.00 ERA): Long has made two starts for the Giants this season. The long-reliever has only seen 5 2-3 innings on the bump in 2022 but hasn't allowed an earned run. Last year, Long pitched 40 2-3 innings with San Francisco, compiling an ERA of 5.53.
Weather
Be sure to monitor the gametime conditions with our MLB weather info.
Key injuries
Athletics: Jed Lowrie 2B (Out), Stephen Vogt C (Out), Chad Pinder LF (Out), Drew Jackson SS (Out), Skye Bolt CF (Out), Kevin Smith 3B (Out).
Giants: Evan Longoria 3B (Out), Tommy La Stella 2B (Out), Mike Yastrzemski RF (Out), Steve Duggar (CF), LaMonte Wade Jr. (Out).
Find our latest MLB injury reports.
Betting trend to know
The Athletics are 5-2 in their last 7 road games with the total set at 7.0-8.5. Find more MLB betting trends for Athletics vs. Giants
Athletics vs Giants picks and predictions
Our side and total predictions are based upon our analysis of the line and total in this game. Our best bet is our favorite pick across all markets.
Moneyline analysis
You'd think San Francisco was due for a slump after an incredible 107-win season under manager Gabe Kapler. That definitely hasn't been the case thus far as the Giants have stormed out of the gate with an impressive 13-5 record, despite the departure of Kris Bryant and retirement of Buster Posey in the offseason.
Even more admirable is the fact that the Giants have been winning with plenty of impact players injured to start the year. Third baseman Evan Longoria has yet to see the field and outfielder LaMonte Wade Jr. is currently on the IL with a knee ailment.
Tonight, the Giants will have long-reliever Sam Long on the mound with starters Alex Cobb and Anthony DeSclafani both injured. Long should only go about two innings before Kapler hands the ball to the rest of the bullpen.
Meanwhile, the Athletics have a bit of an unknown name themselves in Paul Blackburn. He's only faced the Giants once in his career, which came all the way back in 2017. The only current Giants on that lineup then were Brandon Crawford and Brandon Belt, both of whom got hits off of him.
Blackburn will face a Giants team this time around that is averaging 5.1 runs so far, second-most in the league. Outfielder Joc Pederson has gotten off to a great start with his new team, slashing .347/.377/755 with six home runs and 11 RBIs.
Despite all of this, the Athletics may be an underrated play here. Oakland is 6-1 in their last seven games following a loss, and their lineup still ranks middle of the pack in runs per game despite big names like Matt Olson and Starling Marte departing in the offseason.
Seeing the line jump this much in San Francisco's favor has me leaning the other way. I certainly won't be taking the Giants at -170 when they're relying on the bullpen to take them all the way home.
I'll be taking Oakland tonight but this is more of a value play than anything.
Prediction: Athletics moneyline (+150 at bet365)
Over/Under analysis
Oakland starter Paul Blackburn has gotten off to a good start to 2022, however, the Over is 4-0 in Blackburn's last four starts overall.
Although I'm betting on the A's tonight, I have no doubts that the Giants will get their fair share of runs. With that said, I also see the A's getting runners home against Long and the rest of the Giants bullpen. Oakland has fared better at the plate against southpaws than they do righties so far in 2022, and if Long doesn't have his curveball going, he could be in trouble.
Despite an 8-2 win on Tuesday, San Francisco used four relievers in that game with ace Carlos Rodon on the mound. Former Royals starter Jakob Junis could see action in this one when Long is taken out, and Junis had an ERA over 5.00 from 2019-to 2021.
The Over is also 6-2 in the last eight meetings between these two teams in San Francisco.
Prediction: Over 7.0 (-115 at bet365)
Best bet
Sheldon Neuse has been a nice story for the A's so far. DFA'd by the Dodgers in 2021, Neuse is now hitting second in the A's lineup every day and is hitting .327/.397.404 through 16 games (58 at-bats).
Neuse has gotten on base successfully in four of his seven AB's and is a threat on the basepaths as well. Neuse stole two bags successfully yesterday and should be in a prime position to get home at some point in this game.
Bet on Neuse to score a run for Oakland tonight in a matchup featuring weak San Francisco pitching.
Pick: Neuse Over 0.5 runs (+150 at bet365)
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