Blue Jays Picks, Predictions & Best Bets vs the Astros for April 22

With an impressive Chris Bassitt on the mound, the Houston Astros likely won't have the answers that they will need to outdo the Toronto Blue Jays starter as the visitors have the edge to keep the 'Stros at bay.

Andrew Caley - Senior Betting Analyst at Covers.com
Andrew Caley • Senior Betting Analyst
Apr 22, 2025 • 12:26 ET • 4 min read
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This article contains predictions for an old game!

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The Toronto Blue Jays have dropped three games in a row but are hoping that handing the ball to one of the hottest pitchers in baseball will do the trick when they continue their series with the Houston Astros on Tuesday night.

If you haven’t been paying attention to the Jays it may surprise you to learn that pitcher is Chris Bassitt. The right-hander is dealing and gets a great matchup against an Astros lineup that is struggling to start the year.

My Blue Jays predictions break down the best way to bet Bassitt in this American League clash.

Blue Jays predictions for April 22

Today’s Blue Jays best bet: Bassitt to Outplay Astros

Chris Bassitt Over 5.0 Strikeouts (-125 at BetVictor)

Toronto Blue Jays starter Chris Bassitt has been spinning it!

The veteran right-hander, with what seems like an unlimited arsenal of pitches, has looked close to unhittable over his first four starts of the season.

Bassitt has allowed just two earned runs on 20 hits while punching out 31 batters over 23 1/3 innings pitched. His 0.77 ERA is tops in the American League, and the success hasn’t been a fluke.

The 36-year-old owns a 2.86 expected ERA, and is in the 90th percentile when it comes to strikeout rate and there’s no reason to think he can’t continue that success tonight against the Houston Astros.

It’s been a tough start to the season for the Houston Astros offense, and it was looking like more of the same in last night’s opener against Kevin Gausman before a string of hits in the fifth allowed Houston to jump out to a 4-0 lead.

Despite the offensive outburst, the Astros still rank 21st in batting average, 24th in both OPS and wRC+. They also have the 11th highest strikeout rate this season when facing right-handed pitching.

Bassitt has a strikeout prop sitting at 5.0 for this matchup with the Over sitting at a reasonably priced -125. The Jays right-hander has matched this number in all four of his starts this season and has seven or more in three of those starts. 

I like him to keep the Astros off balance long enough to go Over this number once again. 

Today’s Blue Jays same-game parlay (SGP)

Chris Bassitt Over 5.5 Strikeouts

Under 8.5

Bo Bichette Over 1.5 Total Bases

I’m betting Chris Bassitt does his part to shut down the Astros on Tuesday night and with the Blue Jays not having to use any of their best relievers, so all of them should be good to go for Tuesday night’s matchup. 

And while I talked about the Astros' struggles, the Blue Jays have a lot of improving to do themselves. Much has been made of the fact that they have hit the second fewest home runs in the big leagues and tonight they go against a starter who’s had their number in Ronel Blanco.

Blanco no-hit the Jays last season, and while he hasn’t been as effective this year, the lack of pop in the Jays' bats could be a problem. As a team, Toronto has a combined .218 expected batting average against Blanco. So, adding Under 8.5 total runs in tonight’s game makes a lot of sense.

However, one guy with decent numbers against Blanco is Bo Bichette. The Blue Jays' shortstop has looked like his old self this season and trails only Aaron Judge in the AL when it comes to hits.

He enters this game with a .315 average and has multiple hits in five of his last eight games, which includes four doubles. Bichette is also 3-for-6 in his career vs. Blanco with a double and a dinger. So, let’s add Over 1.5 total bases for Bo in this SGP. Some thing he has done in six of his last eight games.

Learn how to bet a same-game parlay with these helpful tips and strategies.

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Live Blue Jays odds for today

How to watch the Blue Jays today

Location Daikin Park, Houston, TX
Date Tuesday, April 22, 2025
First pitch 8:10 p.m. ET
TV Rogers Sportsnet
Blue Jays starting pitcher Chris Bassitt
(2-0, 0.77 ERA)
Astros starting pitcher Ronel Blanco
(1-2, 6.48 ERA)

Not intended for use in MA.
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Senior Betting Analyst

When his dreams of becoming the next Steve Nash died, all Andrew “Taco” Caley wanted to do was write about sports, something he’s been doing at Covers for more than a decade. A Journalism School grad from Holland College in Charlottetown, PEI, Andrew previously worked at The Chronicle Herald and Star Metro, but knew in his heart that his future lay in sports. He began at Covers as a news editor and has now done everything under the sun when it comes to content. His work has been seen on TSN, Sportsnet, VSiN, and CBS.

These days Andrew’s betting expertise is focused on his favorite teams – the Toronto Blue Jays and Toronto Raptors. He’s also an avid college football fan and bettor. He can’t be friends with you if you don’t appreciate a Service Academy Under. You can also call him Covers’ Sixth Man, as he regularly steps up to guest host Before You Bet and our MLB and NCAAF release shows.

The sportsbook where he does the bulk of his betting is bet365 thanks to its numerous prop betting options and competitive odds. His best advice? Find the balance between the numbers and what you see on the playing field. Then find the best price using multiple books. And don’t ask him where the nickname Taco comes from. It’s not an interesting story. Seriously.

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