Iowa State vs Colorado Prediction, Picks, and Odds for Tonight’s College Basketball Game

Colorado got tuned up by Iowa State when these teams met in the Maui Invitational, but the Buffaloes are a different (see: better) team on their home soil. They may not win, but they'll keep it within the spread.

Eric Rosales - Betting Analyst at Covers.com
Eric Rosales • Betting Analyst
Dec 29, 2024 • 22:06 ET • 4 min read
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This article contains predictions for an old game!

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The third-ranked Iowa State Cyclones open Big 12 Conference play when they visit the Colorado Buffaloes with the tip scheduled at 9 p.m. ET at the CU Events Center in Boulder

It’s a rematch from the Maui Invitational, where the Cyclones crushed the Buffs, a big reason they are 9-point favorites. Still, our Iowa State vs Colorado predictions think the Buffaloes can compete, especially at home.

Let's dig in with our college basketball picks for Monday, December 30.

Iowa State vs Colorado prediction

My best bet
Colorado +9.5 (-110 at bet365)

My analysis

The Iowa State Cyclones are rolling heading into Boulder, having reeled off wins in seven straight, including an 11-point win over fifth-ranked Marquette.

Iowa State currently ranks fifth overall at KenPom, sitting Top 3 in offensive efficiency. The Cyclones are scoring 88.5 points per game and shooting at a tremendous 51.3% clip from the field, which ranks eighth in college hoops.

They moved to 10-1 on the year with a 99-72 obliteration of Morgan State, the seventh time this year they have won by more than 20 points.

Their defensive splits aren’t great, but they are Top 40 in points allowed while forcing 16 turnovers per game (sixth).

The Colorado Buffaloes haven’t lost since taking that 99-71 beating from these same Cyclones on November 27, reeling off four straight wins, all by double figures.

The Buffaloes dumped Bellarmine 79-55 last game to get to 9-2 on the season and improved to a perfect 8-0 at home, where they are averaging 80.5 points and allowing just 63.6 per.

While the Cyclones have looked good, there might be a slight over-emphasis of that previous head-to-head result. Full credit to Iowa State, who shot a blistering 60.3% from the field, including 11-for-25 from distance (44.0%), but the Buffaloes got killed on the margins.

Colorado’s 18 turnovers turned into 37 points for the Cyclones, and they were run off the court, with ISU racking up a 22-6 advantage in fast break points.

This was the second game in two nights for the Buffs, who probably couldn’t avoid an emotional letdown after beating then 2nd-ranked UConn the night before.

Both schools have played just two ranked teams each, and their KenPom strength of schedule ratings are similar, ranking outside the Top 245.

Even if Iowa State wins, these two teams match up closer than a double-digit Cyclones spread.

Iowa State vs Colorado same-game parlay

Colorado +9.5

Over 147

Iowa State is the highest-scoring team in the Big 12, and Colorado is scoring in the 80s when playing at home.

Defensively, these teams aren’t exactly stoppers: both the Cyclones and Buffs rank outside the Top 90 in field goal shooting percentage.

Iowa State is 180th in 3-point shooting percentage allowed, with Colorado outside the Top 100.

The Cyclones have cashed the Over in three of their last four, and the Over has hit four times in the last six head-to-head meetings between these schools.

The points will be there.

Learn how to bet a same-game parlay with these helpful tips and strategies.

Cash your ML bets quicker with bet365's early win payout

Take advantage of the early win payout at bet365, where any pre-game CBB moneyline bet gets paid out as a winner if your school goes up by 18+ points!

Learn more about this feature, and all of bet365's offerings, with our comprehensive bet365 review.

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Iowa State vs Colorado odds

Iowa State vs Colorado live odds

Iowa State vs Colorado opening odds

  • Spread: Iowa State -9 (-115) | Colorado +9 (-105)
  • Moneyline: Iowa State -450 | Colorado +350
  • Over/Under: Over 147.5 (-110) | Under 147.5 (-110)

Odds courtesy of bet365

Iowa State vs Colorado betting trend to know

The Cyclones have won 14 straight night games against unranked opponents. Find more college basketball betting trends for Iowa State vs. Colorado.

How to watch Iowa State vs Colorado

Location: CU Events Center, Boulder, CO
Date: Monday, 12-30-2024
Tip-off: 9:00 p.m. ET
TV: CBSSN

Iowa State vs Colorado key injuries

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Eric Rosales - Covers
Betting Analyst

Eric has been involved in sports media in many different capacities since graduating from journalism school in 1999, back when getting your own column in a newspaper was still considered a thing. He doubled down and graduated from broadcast journalism school five years later, which led to a move to Toronto and a career with The Sports Network (TSN). From behind-the-scenes production work, he moved into the digital realm, where he had his own hoops column (At the Buzzer), while regularly live streaming and chatting with fans during broadcasts as the character known as LeBlog James. He was also a key contributor to TSN and CTV’s Olympic programming during the 2012 London Games.

Eric eventually found his way into the sports betting field in 2016 and has been a mainstay ever since. He was tagged on Twitter as a Top 10 NBA sharp during the 2021 season and has been interviewed about basketball and his handicapping process on shows from Vancouver to India. Eric is now a jack-of-all-sports at Covers, where his predictions span the alphabet soup: NFL, NBA, MLB, NHL, F1, WNBA, Euro, and Copa.

When making picks, he focuses on finding value first and foremost, and ensuring readers have all the information they need to make an informed choice.

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